{"title":"notch1相关主动脉瘤线粒体丢失的发现和靶向","authors":"","doi":"10.1038/s44161-025-00607-3","DOIUrl":null,"url":null,"abstract":"We established a mouse model of progressive aortic aneurysm induced by conditional Notch1 deficiency in vascular smooth muscle cells. Notch1 deficiency impairs the transcription of genes involved in mitochondrial fusion and biogenesis, thereby triggering aortic pathology. Early intervention to enhance these mitochondrial processes could potentially slow disease progression.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 2","pages":"129-130"},"PeriodicalIF":12.6000,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Discovering and targeting mitochondrial loss in NOTCH1-related aortic aneurysm\",\"authors\":\"\",\"doi\":\"10.1038/s44161-025-00607-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We established a mouse model of progressive aortic aneurysm induced by conditional Notch1 deficiency in vascular smooth muscle cells. Notch1 deficiency impairs the transcription of genes involved in mitochondrial fusion and biogenesis, thereby triggering aortic pathology. Early intervention to enhance these mitochondrial processes could potentially slow disease progression.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 2\",\"pages\":\"129-130\"},\"PeriodicalIF\":12.6000,\"publicationDate\":\"2025-01-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-025-00607-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00607-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Discovering and targeting mitochondrial loss in NOTCH1-related aortic aneurysm
We established a mouse model of progressive aortic aneurysm induced by conditional Notch1 deficiency in vascular smooth muscle cells. Notch1 deficiency impairs the transcription of genes involved in mitochondrial fusion and biogenesis, thereby triggering aortic pathology. Early intervention to enhance these mitochondrial processes could potentially slow disease progression.
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