Gabriel K. Adzika, Ricardo A. Velázquez Aponte, Joseph A. Baur
{"title":"线粒体NAD+转运体SLC25A51与人类主动脉疾病有关","authors":"Gabriel K. Adzika, Ricardo A. Velázquez Aponte, Joseph A. Baur","doi":"10.1038/s44161-024-00599-6","DOIUrl":null,"url":null,"abstract":"An extensive molecular characterization of 150 human thoracic aorta specimens followed by genetic association studies and preclinical work in mice implicates the mitochondrial NAD+ transporter SLC25A51 in the pathogenesis of aortic disease.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 3","pages":"256-258"},"PeriodicalIF":12.6000,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mitochondrial NAD+ transporter SLC25A51 linked to human aortic disease\",\"authors\":\"Gabriel K. Adzika, Ricardo A. Velázquez Aponte, Joseph A. Baur\",\"doi\":\"10.1038/s44161-024-00599-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An extensive molecular characterization of 150 human thoracic aorta specimens followed by genetic association studies and preclinical work in mice implicates the mitochondrial NAD+ transporter SLC25A51 in the pathogenesis of aortic disease.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 3\",\"pages\":\"256-258\"},\"PeriodicalIF\":12.6000,\"publicationDate\":\"2025-01-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-024-00599-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00599-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Mitochondrial NAD+ transporter SLC25A51 linked to human aortic disease
An extensive molecular characterization of 150 human thoracic aorta specimens followed by genetic association studies and preclinical work in mice implicates the mitochondrial NAD+ transporter SLC25A51 in the pathogenesis of aortic disease.
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