Xiaomei Wu , Zhongyin Chen , Jinyu Wang , Linwei Li , Yuhao Guo , Ziqiang Xu , Ying Kuang , Tao Liao , Cao Li
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引用次数: 0
摘要
光热疗法（PTT）和气体疗法（GT）在纳米平台上的集成在癌症治疗中显示出巨大的潜力。本文基于普鲁士蓝（PB）纳米粒子、5-氯-2-硝基苯并三氟（NF）接枝的聚赖氨酸（PLL(NF)）和叶酸（FA），设计了肿瘤靶向近红外/紫外（NIR/UV）触发的PTT/GT协同治疗纳米平台PB- cd -PLL(NF)-FA。PB是通过主-客交互加载PLL（NF）的核心，可以进一步修改FA。PB-CD-PLL(NF)-FA可通过增强通透性和滞留性（EPR）效应的被动靶向和FA的主动靶向在肿瘤组织中富集，并可在紫外光照射下促进NF的分解，实现一氧化氮（NO）的精确释放。PB在近红外区具有良好的光热转换效率，可用于PTT。体内和体外研究结果表明，PB-CD-PLL(NF)-FA在近红外激光照射下具有较高的光热转化效率，在紫外光照射下可按需释放NO，对肿瘤PTT/GT具有良好的协同治疗作用。
Tumor-targeted near-infrared/ultraviolet-triggered photothermal/gas therapy nanoplatform for effective cancer synergistic therapy
The integration of photothermal therapy (PTT) and gas therapy (GT) on a nanoplatform shows great potential in cancer treatment. In this paper, a tumor-targeted near-infrared/ultraviolet (NIR/UV) triggered PTT/GT synergistic therapeutic nanoplatform, PB-CD-PLL(NF)-FA, was designed based on Prussian blue (PB) nanoparticles, 5-chloro-2-nitrobenzotrifluoro (NF)-grafted polylysine (PLL(NF)), and folic acid (FA). PB serves as a core to load PLL(NF) through host-guest interaction and can further modify FA. PB-CD-PLL(NF)-FA can be enriched in tumor tissues by passive targeting with enhanced permeability and retention (EPR) effect and active targeting with FA, and can promote the decomposition of NF under UV light irradiation to achieve the precise release of nitric oxide (NO). PB has a good photothermal conversion efficiency in the NIR region and can be used for PTT. The results of in vivo and in vitro studies showed that PB-CD-PLL(NF)-FA has high photothermal conversion efficiency under NIR laser irradiation, and can release NO on demand under UV light irradiation, which shows a good synergistic therapeutic effect of tumor PTT/GT.
期刊介绍：
Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields.
Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication.
The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.
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