V Hovsepyan, G Arajyan, A Al-Chachani, G Musheghyan, J Sarkissian, I Gabrielyan
{"title":"在氢化可的松保护条件下，基底外侧杏仁核在帕金森病模型上激活的大脑Еntorhinal皮层神经元兴奋性和抑制性突触过程的比例。","authors":"V Hovsepyan, G Arajyan, A Al-Chachani, G Musheghyan, J Sarkissian, I Gabrielyan","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Parkinson disease (PD) is a common neurodegenerative condition. It affects the central nervous system, and it impairs cognitive processes, motor skills and other functions. The aim of this study was to determine the synaptic processes in medial Entorhinal cortex (mENT) under High frequency stimulation of Basolateral Amygdala on the model of Parkinson's disease under the influence of Hydrocortisone. Rotenone is involved in the degeneration of dopaminergic neurons. We investigated whether hydrocortison protects against rotenone-induced dopaminergic neurotoxicity in a rat model by in vivo electrical recording from medial Entorhinal cortex. Hydrocortison significantly improved electrical activity of neurons in the mENT of rotenone-induced PD model rats.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 356","pages":"50-58"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"THE RATIO OF EXCITATORY AND INHIBITORY SYNAPTIC PROCESSES IN NEURONS OF THE ЕNTORHINAL CORTEX OF THE BRAIN, ACTIVATED BY BASOLATERAL AMYGDALA ON THE MODEL OF PARKINSON'S DISEASE, UNDER CONDITIONS OF PROTECTION BY HYDROCORTISONE.\",\"authors\":\"V Hovsepyan, G Arajyan, A Al-Chachani, G Musheghyan, J Sarkissian, I Gabrielyan\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Parkinson disease (PD) is a common neurodegenerative condition. It affects the central nervous system, and it impairs cognitive processes, motor skills and other functions. The aim of this study was to determine the synaptic processes in medial Entorhinal cortex (mENT) under High frequency stimulation of Basolateral Amygdala on the model of Parkinson's disease under the influence of Hydrocortisone. Rotenone is involved in the degeneration of dopaminergic neurons. We investigated whether hydrocortison protects against rotenone-induced dopaminergic neurotoxicity in a rat model by in vivo electrical recording from medial Entorhinal cortex. Hydrocortison significantly improved electrical activity of neurons in the mENT of rotenone-induced PD model rats.</p>\",\"PeriodicalId\":12610,\"journal\":{\"name\":\"Georgian medical news\",\"volume\":\" 356\",\"pages\":\"50-58\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Georgian medical news\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Georgian medical news","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
THE RATIO OF EXCITATORY AND INHIBITORY SYNAPTIC PROCESSES IN NEURONS OF THE ЕNTORHINAL CORTEX OF THE BRAIN, ACTIVATED BY BASOLATERAL AMYGDALA ON THE MODEL OF PARKINSON'S DISEASE, UNDER CONDITIONS OF PROTECTION BY HYDROCORTISONE.
Parkinson disease (PD) is a common neurodegenerative condition. It affects the central nervous system, and it impairs cognitive processes, motor skills and other functions. The aim of this study was to determine the synaptic processes in medial Entorhinal cortex (mENT) under High frequency stimulation of Basolateral Amygdala on the model of Parkinson's disease under the influence of Hydrocortisone. Rotenone is involved in the degeneration of dopaminergic neurons. We investigated whether hydrocortison protects against rotenone-induced dopaminergic neurotoxicity in a rat model by in vivo electrical recording from medial Entorhinal cortex. Hydrocortison significantly improved electrical activity of neurons in the mENT of rotenone-induced PD model rats.
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