从卡尼诺卡菌IFM 12324中分离得到一个新的二萜类化合物卡尼二醇。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL Journal of Natural Medicines Pub Date : 2025-01-28 DOI:10.1007/s11418-025-01878-7

Yasumasa Hara, Ayaka Nakamura, Teruhisa Manome, Akiko Takaya, Hiroki Takahashi, Sayaka Ban, Takashi Yaguchi, Masami Ishibashi

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摘要

从卡尼诺卡菌IFM 12324的培养提取物中分离到一种新的二萜类化合物卡尼二醇(1)，具有前所未有的三环碳骨架。化合物1的结构是通过波谱研究，包括各种核磁共振数据来阐明的。用结晶海绵法x射线晶体学分析确定了1的绝对构型。推导出化合物1的生物合成基因，发现产生化合物1的菌株中萜类环化相关基因mRNA显著升高。

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A new diterpenoid, carneadiol, isolated from Nocardia carnea IFM 12324

A new diterpenoid, carneadiol (1), with an unprecedented tricyclic carbon skeleton, was isolated from the culture extracts of Nocardia carnea IFM 12324. The structure of compound 1 was elucidated using spectral studies, including various NMR data. The absolute configuration of 1 was determined using X-ray crystallographic analysis with the crystalline sponge method. The biosynthetic gene of compound 1 was deduced, and it was observed that the mRNA of the gene involved in terpenoid cyclization increased significantly in the strain producing compound 1.

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.