Pyoderma Gangrenosum Improved with Dapsone and Prednisone: A Case Report.

Abstract: Pyoderma gangrenosum is a rare ulcerative condition that poses diagnostic and therapeutic challenges. Diagnosis and appropriate management are often delayed due to its rarity and the presence of numerous clinical variants. In this case report, the authors present the case of a 36-year-old man who had long-standing and nonhealing ulcers that did not respond to multiple antibiotics and serial wound debridement. The patient was promptly initiated on oral corticosteroids and dapsone as an adjunctive steroid agent. After 6 months, the patient reported complete resolution of the lesions. This rare case underscores the potential value of combining prednisone and dapsone as a treatment option for pyoderma gangrenosum, particularly in resource-limited settings.