Yeshwanth Edamadaka, Rahul V Parghane, Sandip Basu
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引用次数: 0
摘要
弥漫性大b细胞淋巴瘤（DLBCL）是最常见的非霍奇金淋巴瘤类型，相当一部分DLBCL患者表现为晚期，复发和难治性疾病，对标准化疗方案的反应较差。放射免疫治疗（RIT）已被证明是临床有效的难治性DLBCL。我们报告1例DLBCL患者[18F]FDG广泛累及骨骼和脾脏，FDG PET/CT显示为预后不良的结外疾病。探讨基于[177Lu] lu - dota -利妥昔单抗的RIT，研究[177Lu] lu - dota -利妥昔单抗在cd20阳性淋巴瘤中的生物分布及剂量学。在骨骼和脾脏疾病中观察到异常高的示踪剂浓度，支持其在未来复发和难治性DLBCL患者中的潜在RIT应用。
Tumor Lesion Uptake of [ 177 Lu]Lu-DOTA-Rituximab in Skeletal and Splenic Disease in Diffuse Large B-Cell Lymphoma.
Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, and a sizable fraction of the DLBCL patients presents with advanced, relapsed, and refractory disease, demonstrating poor response to standard chemotherapy regimens. Radioimmunotherapy (RIT) has shown to be clinically effective in refractory DLBCL. We present the case of a patient with DLBCL with [ 18 F]FDG-avid widespread skeletal as well as splenic involvement as poor prognostic extranodal disease on FDG PET/CT. RIT based on [ 177 Lu]Lu-DOTA-rituximab was explored to study the biodistribution and dosimetry of [ 177 Lu]Lu-DOTA-rituximab in CD20-positive lymphoma. An exceptionally high tracer concentration in skeletal and splenic disease was observed, supporting its potential RIT application in relapsed and refractory DLBCL patients in the future.
期刊介绍：
Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty.
Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.
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