Shiyi Yin , Jinyuan Wang , Haihan Zhang , Xuan Yang , Jingting Luo , Wenbin Wei
{"title":"定量扫描源光学相干断层扫描血管造影（SS-OCTA）分析Bietti晶体营养不良患者黄斑微血管改变。","authors":"Shiyi Yin , Jinyuan Wang , Haihan Zhang , Xuan Yang , Jingting Luo , Wenbin Wei","doi":"10.1016/j.pdpdt.2025.104485","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>Bietti crystalline dystrophy (BCD) is a rare retinal dystrophy characterized by progressive visual impairment. This study aimed to evaluate changes in retinal and choroidal vessels and blood flow in BCD patients using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate potential parameters associated with visual function.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 166 eyes from 86 clinically diagnosed BCD patients, classified into three disease stages based on Yuzawa's classification. OCTA imaging (VG200S; SVision Imaging, Henan, China) covered a 12 mm × 12 mm area of the macula, measuring thickness, vessel density (VD), perfusion area (PA), choroidal vascularity index (CVI), choroidal vascularity volume (CVV), and foveal avascular zone (FAZ) metrics. Associations between OCTA parameters and visual function metrics, including best-corrected visual acuity (BCVA), mean deviation (MD) and visual field index (VFI) of the Humphrey visual field test, were analyzed.</div></div><div><h3>Results</h3><div>By stage 3, 92 % of eyes exhibited an undetectable ellipsoid zone (EZ). From stage 1 to stage 2, VD in all retinal layers decreased significantly (<em>P</em> < 0.05), whereas differences between stages 2 and 3 were not statistically significant (<em>P</em> > 0.05). The FAZ area and perimeter showed no significant difference across the three stages (<em>P</em> > 0.05). Choroidal parameters, including PA, CVI, and CVV, progressively decreased across all stages (<em>P</em> < 0.001). Multivariate regression analysis revealed that SVC-VD (<em>P</em> < 0.001), SVC-PA (<em>P</em> < 0.001) and choroid-PA (<em>P</em> = 0.030) were significantly associated with BCVA, while DVC-VD (<em>P</em> = 0.014), outer retinal thickness (<em>P</em> = 0.011), and CVI (<em>P</em> = 0.004) were significantly associated with visual field damage.</div></div><div><h3>Conclusions</h3><div>SS-OCTA effectively quantifies the progressive microvascular changes in the retina and choroid associated with BCD. Retinal vascular alterations are prominent in the early stages of the disease, whereas choroidal damage persists throughout its progression. OCTA parameters of the retina and choroid demonstrate varying degrees of correlation with visual function, underscoring their potential as biomarkers for monitoring disease progression and evaluating therapeutic efficacy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104485"},"PeriodicalIF":2.6000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Quantitative swept-source optical coherence tomography angiography (SS-OCTA) analysis of macular microvascular alterations in Bietti crystalline dystrophy\",\"authors\":\"Shiyi Yin , Jinyuan Wang , Haihan Zhang , Xuan Yang , Jingting Luo , Wenbin Wei\",\"doi\":\"10.1016/j.pdpdt.2025.104485\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>Bietti crystalline dystrophy (BCD) is a rare retinal dystrophy characterized by progressive visual impairment. This study aimed to evaluate changes in retinal and choroidal vessels and blood flow in BCD patients using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate potential parameters associated with visual function.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 166 eyes from 86 clinically diagnosed BCD patients, classified into three disease stages based on Yuzawa's classification. OCTA imaging (VG200S; SVision Imaging, Henan, China) covered a 12 mm × 12 mm area of the macula, measuring thickness, vessel density (VD), perfusion area (PA), choroidal vascularity index (CVI), choroidal vascularity volume (CVV), and foveal avascular zone (FAZ) metrics. Associations between OCTA parameters and visual function metrics, including best-corrected visual acuity (BCVA), mean deviation (MD) and visual field index (VFI) of the Humphrey visual field test, were analyzed.</div></div><div><h3>Results</h3><div>By stage 3, 92 % of eyes exhibited an undetectable ellipsoid zone (EZ). From stage 1 to stage 2, VD in all retinal layers decreased significantly (<em>P</em> < 0.05), whereas differences between stages 2 and 3 were not statistically significant (<em>P</em> > 0.05). The FAZ area and perimeter showed no significant difference across the three stages (<em>P</em> > 0.05). Choroidal parameters, including PA, CVI, and CVV, progressively decreased across all stages (<em>P</em> < 0.001). Multivariate regression analysis revealed that SVC-VD (<em>P</em> < 0.001), SVC-PA (<em>P</em> < 0.001) and choroid-PA (<em>P</em> = 0.030) were significantly associated with BCVA, while DVC-VD (<em>P</em> = 0.014), outer retinal thickness (<em>P</em> = 0.011), and CVI (<em>P</em> = 0.004) were significantly associated with visual field damage.</div></div><div><h3>Conclusions</h3><div>SS-OCTA effectively quantifies the progressive microvascular changes in the retina and choroid associated with BCD. Retinal vascular alterations are prominent in the early stages of the disease, whereas choroidal damage persists throughout its progression. OCTA parameters of the retina and choroid demonstrate varying degrees of correlation with visual function, underscoring their potential as biomarkers for monitoring disease progression and evaluating therapeutic efficacy.</div></div>\",\"PeriodicalId\":20141,\"journal\":{\"name\":\"Photodiagnosis and Photodynamic Therapy\",\"volume\":\"52 \",\"pages\":\"Article 104485\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Photodiagnosis and Photodynamic Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1572100025000158\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodiagnosis and Photodynamic Therapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1572100025000158","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/26 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Quantitative swept-source optical coherence tomography angiography (SS-OCTA) analysis of macular microvascular alterations in Bietti crystalline dystrophy
Purpose
Bietti crystalline dystrophy (BCD) is a rare retinal dystrophy characterized by progressive visual impairment. This study aimed to evaluate changes in retinal and choroidal vessels and blood flow in BCD patients using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate potential parameters associated with visual function.
Methods
This cross-sectional study included 166 eyes from 86 clinically diagnosed BCD patients, classified into three disease stages based on Yuzawa's classification. OCTA imaging (VG200S; SVision Imaging, Henan, China) covered a 12 mm × 12 mm area of the macula, measuring thickness, vessel density (VD), perfusion area (PA), choroidal vascularity index (CVI), choroidal vascularity volume (CVV), and foveal avascular zone (FAZ) metrics. Associations between OCTA parameters and visual function metrics, including best-corrected visual acuity (BCVA), mean deviation (MD) and visual field index (VFI) of the Humphrey visual field test, were analyzed.
Results
By stage 3, 92 % of eyes exhibited an undetectable ellipsoid zone (EZ). From stage 1 to stage 2, VD in all retinal layers decreased significantly (P < 0.05), whereas differences between stages 2 and 3 were not statistically significant (P > 0.05). The FAZ area and perimeter showed no significant difference across the three stages (P > 0.05). Choroidal parameters, including PA, CVI, and CVV, progressively decreased across all stages (P < 0.001). Multivariate regression analysis revealed that SVC-VD (P < 0.001), SVC-PA (P < 0.001) and choroid-PA (P = 0.030) were significantly associated with BCVA, while DVC-VD (P = 0.014), outer retinal thickness (P = 0.011), and CVI (P = 0.004) were significantly associated with visual field damage.
Conclusions
SS-OCTA effectively quantifies the progressive microvascular changes in the retina and choroid associated with BCD. Retinal vascular alterations are prominent in the early stages of the disease, whereas choroidal damage persists throughout its progression. OCTA parameters of the retina and choroid demonstrate varying degrees of correlation with visual function, underscoring their potential as biomarkers for monitoring disease progression and evaluating therapeutic efficacy.
期刊介绍：
Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.
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