具有双重抗真菌机制的先进肽纳米酶：对抗抗菌素耐药性的前沿创新。

IF 2.6 3区生物学 Q3 MICROBIOLOGY Current Microbiology Pub Date : 2025-01-30 DOI:10.1007/s00284-025-04094-4

Ganeshraja Ayyakannu Sundaram

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引用次数: 0

摘要

这封信赞扬了最近关于“双作用抗真菌肽纳米酶：对抗抗菌素耐药性的新方法”的创新研究成果。该研究引入了一种开创性的方法，通过从头设计和肽组装来开发模仿抗菌肽和酶的肽纳米酶，以解决抗菌素耐药性问题。利用AlphaFold2和分子动力学模拟设计的七肽IHIHICI具有高稳定性和双重抗真菌作用，可在10分钟内有效杀死90%以上的白色假丝酵母。该研究在多功能抗菌材料的开发中取得了重大进展，具有广阔的生物医学应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advanced Peptide Nanozymes with Dual Antifungal Mechanisms: Cutting-Edge Innovations in Combatting Antimicrobial Resistance.

This letter commends the recent innovative research findings on "Dual-Action Antifungal Peptide Nanozymes: A Novel Approach to Combatting Antimicrobial Resistance." The study introduces a pioneering method to address antimicrobial resistance by developing peptide nanozymes that mimic antimicrobial peptides and enzymes through de novo design and peptide assembly. The heptapeptide IHIHICI, designed using AlphaFold2 and molecular dynamics simulations, exhibits high stability and dual antifungal actions, effectively killing over 90% of Candida albicans within 10 min. This research represents a significant advancement in the development of multifunctional antimicrobial materials, with promising biomedical applications.

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来源期刊

Current Microbiology 生物-微生物学

CiteScore

4.80

自引率

3.80%

发文量

380

审稿时长

2.5 months

期刊介绍： Current Microbiology is a well-established journal that publishes articles in all aspects of microbial cells and the interactions between the microorganisms, their hosts and the environment. Current Microbiology publishes original research articles, short communications, reviews and letters to the editor, spanning the following areas: physiology, biochemistry, genetics, genomics, biotechnology, ecology, evolution, morphology, taxonomy, diagnostic methods, medical and clinical microbiology and immunology as applied to microorganisms.