全国健康与营养调查中氧化平衡评分与青光眼的关系

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS Frontiers in Nutrition Pub Date : 2025-01-15 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1528114

Jun Huang, Yulan Zhang, Chao Wu, Yifan Wu, Feiran Wang, Yunxuan Ning, Lu Shi

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摘要

目的：探讨氧化平衡评分（OBS）与青光眼发病的关系。方法：使用2005-2008年全国健康与营养调查的数据，我们分析了2615名年龄≥40 岁的参与者。OBS由15种抗氧化成分和5种促氧化成分计算，包括膳食营养素和生活方式因素。青光眼通过自我报告诊断和视网膜成像确诊。使用调查加权逻辑回归和限制性三次样条（RCS）来评估相关性。结果：较高的OBS与较低的青光眼风险相关（调整OR： = 0.97,95% CI: 0.94-1.00）。OBS最高四分位数的参与者患青光眼的几率比最低四分位数的参与者低51%（调整OR = 0.49,95% CI: 0.27-0.90）。中年人(40-60 岁；或 = 0.90,95%置信区间:0.86—-0.95),男性(或 = 0.93,95%置信区间CI: 0.90 - -0.97)。结论：较高的OBS与较低的青光眼患病率相关，特别是在中年人和男性中，这表明维持氧化平衡对预防青光眼有潜在的好处。

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Association between oxidative balance score and glaucoma in the National Health and Nutrition Examination Survey.

Objective: To investigate the association between Oxidative Balance Score (OBS) and glaucoma risk.

Methods: Using data from the National Health and Nutrition Examination Survey (2005-2008), we analyzed 2,615 participants aged ≥40 years. OBS was calculated from 15 antioxidant and 5 pro-oxidant components, including dietary nutrients and lifestyle factors. Glaucoma was identified through self-reported diagnosis and retinal imaging. Survey-weighted logistic regression and restricted cubic splines (RCS) were used to assess associations.

Results: Higher OBS was associated with lower glaucoma risk (adjusted OR = 0.97, 95% CI: 0.94-1.00). Participants in the highest OBS quartile showed 51% lower odds of glaucoma compared to the lowest quartile (adjusted OR = 0.49, 95% CI: 0.27-0.90). The protective effect was more pronounced among middle-aged adults (40-60 years; OR = 0.90, 95% CI: 0.86-0.95) and males (OR = 0.93, 95% CI: 0.90-0.97).

Conclusion: Higher OBS were associated with lower glaucoma prevalence, particularly among middle-aged adults and males, suggesting potential benefits of maintaining oxidative balance in glaucoma prevention.

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.