与工作年龄的成年人相比,年轻人和老年人如何从认知行为疗法中受益?一个大型的多中心自然主义研究。

IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Journal of affective disorders Pub Date : 2025-04-15 Epub Date: 2025-01-29 DOI:10.1016/j.jad.2025.01.145
Nicolas Wrede , Mareike C. Hillebrand , Anne Katrin Risch , Georg W. Alpers , Stephan Bartholdy , Eva-Lotta Brakemeier , Anne-Kathrin Bräscher , Timo Brockmeyer , Hanna Christiansen , Monika Equit , Lydia Fehm , Thomas Forkmann , Julia Glombiewski , Jens Heider , Sylvia Helbig-Lang , Andrea Hermann , Christiane Hermann , Jürgen Hoyer , Tina In-Albon , Tim Klucken , Gabriele Wilz
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引用次数: 0

摘要

背景:虽然荟萃分析表明认知行为疗法(CBT)对老年人的疗效与工作年龄的成年人相当,但对其在不同年龄组的自然环境中的有效性知之甚少。因此,本研究比较了工作年龄成人(18-64 岁)、年轻老年人(65-74 岁)和老年老年人(≥75 岁)在门诊CBT中的症状变化、减少率和治疗时间。方法:我们分析了一个大型的自然数据集,包括9081名18 - 96 岁的德国门诊CBT患者。使用倾向评分匹配,我们检查了工作年龄、年轻人和老年人的可比组之间治疗反应、缓解、磨损和持续时间的差异。结果:在简短症状量表(BSI-53)和患者和临床评定的主观改善(CGI-I)方面,三个年龄组之间的缓解率和缓解率没有差异。青年人和老年人在贝克抑郁量表(BDI-II)上的反应和缓解率较低。这些差异仅限于评估躯体化的项目,这可能与正常的衰老有关。与工作年龄的成年人相比,年轻人和老年人的治疗时间较短。流失率没有差别。局限性:老年人的样本相对较少,可能是选择性的。特别是,居家、易受伤害的老年人可能代表性不足。此外,观察性研究的设计限制了研究结果的可解释性。结论:年轻人和老年人似乎从门诊CBT中受益的程度与工作年龄的成年人相似。在实践和未来的研究中,应承认与年龄相关的躯体疾病在结果测量中的潜在偏差。
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How do young-old and old-old adults benefit from cognitive-behavioral therapy compared to working-age adults? A large multicenter naturalistic study

Background

Although meta-analyses suggest comparable efficacy of cognitive-behavioral therapy (CBT) in older adults compared to working-age adults, little is known about its effectiveness in naturalistic settings across different age groups. Hence, this study compared symptom change, attrition rates, and treatment duration in outpatient CBT between working-age adults (18–64 years), young-old adults (65–74 years), and old-old adults (≥ 75 years).

Methods

We analyzed a large naturalistic dataset comprising 9081 patients between 18 and 96 years receiving outpatient CBT in Germany. Using propensity score matching, we examined differences in treatment response, remission, attrition, and duration between comparable groups of working-age, young-old, and old-old adults.

Results

Response and remission rates did not differ between the three age groups in terms of the Brief Symptom Inventory (BSI-53) and patient- and clinician-rated subjective improvement (CGI-I). Young-old and old-old adults showed lower rates of response and remission on the Beck Depression Inventory (BDI-II). These differences were limited to items assessing somatization, which may be related to normal aging. Treatment duration was shorter in young-old and old-old adults compared to working-age adults. Attrition rates did not differ.

Limitations

The samples of older adults were relatively small and probably selective. Especially, home-bound, vulnerable older adults may be underrepresented. Further, the observational study design limits interpretability of findings.

Conclusions

Young-old and old-old adults seem to benefit from outpatient CBT to a similar extent as working-age adults. Potential bias in outcome measures due to age-related somatic complaints should be acknowledged in practice and future research.
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来源期刊
Journal of affective disorders
Journal of affective disorders 医学-精神病学
CiteScore
10.90
自引率
6.10%
发文量
1319
审稿时长
9.3 weeks
期刊介绍: The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.
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