Nicolas Wrede , Mareike C. Hillebrand , Anne Katrin Risch , Georg W. Alpers , Stephan Bartholdy , Eva-Lotta Brakemeier , Anne-Kathrin Bräscher , Timo Brockmeyer , Hanna Christiansen , Monika Equit , Lydia Fehm , Thomas Forkmann , Julia Glombiewski , Jens Heider , Sylvia Helbig-Lang , Andrea Hermann , Christiane Hermann , Jürgen Hoyer , Tina In-Albon , Tim Klucken , Gabriele Wilz
{"title":"与工作年龄的成年人相比,年轻人和老年人如何从认知行为疗法中受益?一个大型的多中心自然主义研究。","authors":"Nicolas Wrede , Mareike C. Hillebrand , Anne Katrin Risch , Georg W. Alpers , Stephan Bartholdy , Eva-Lotta Brakemeier , Anne-Kathrin Bräscher , Timo Brockmeyer , Hanna Christiansen , Monika Equit , Lydia Fehm , Thomas Forkmann , Julia Glombiewski , Jens Heider , Sylvia Helbig-Lang , Andrea Hermann , Christiane Hermann , Jürgen Hoyer , Tina In-Albon , Tim Klucken , Gabriele Wilz","doi":"10.1016/j.jad.2025.01.145","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Although meta-analyses suggest comparable efficacy of cognitive-behavioral therapy (CBT) in older adults compared to working-age adults, little is known about its effectiveness in naturalistic settings across different age groups. Hence, this study compared symptom change, attrition rates, and treatment duration in outpatient CBT between working-age adults (18–64 years), young-old adults (65–74 years), and old-old adults (≥ 75 years).</div></div><div><h3>Methods</h3><div>We analyzed a large naturalistic dataset comprising 9081 patients between 18 and 96 years receiving outpatient CBT in Germany. Using propensity score matching, we examined differences in treatment response, remission, attrition, and duration between comparable groups of working-age, young-old, and old-old adults.</div></div><div><h3>Results</h3><div>Response and remission rates did not differ between the three age groups in terms of the Brief Symptom Inventory (BSI-53) and patient- and clinician-rated subjective improvement (CGI-I). Young-old and old-old adults showed lower rates of response and remission on the Beck Depression Inventory (BDI-II). These differences were limited to items assessing somatization, which may be related to normal aging. Treatment duration was shorter in young-old and old-old adults compared to working-age adults. Attrition rates did not differ.</div></div><div><h3>Limitations</h3><div>The samples of older adults were relatively small and probably selective. Especially, home-bound, vulnerable older adults may be underrepresented. Further, the observational study design limits interpretability of findings.</div></div><div><h3>Conclusions</h3><div>Young-old and old-old adults seem to benefit from outpatient CBT to a similar extent as working-age adults. Potential bias in outcome measures due to age-related somatic complaints should be acknowledged in practice and future research.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"375 ","pages":"Pages 456-464"},"PeriodicalIF":4.9000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"How do young-old and old-old adults benefit from cognitive-behavioral therapy compared to working-age adults? A large multicenter naturalistic study\",\"authors\":\"Nicolas Wrede , Mareike C. Hillebrand , Anne Katrin Risch , Georg W. Alpers , Stephan Bartholdy , Eva-Lotta Brakemeier , Anne-Kathrin Bräscher , Timo Brockmeyer , Hanna Christiansen , Monika Equit , Lydia Fehm , Thomas Forkmann , Julia Glombiewski , Jens Heider , Sylvia Helbig-Lang , Andrea Hermann , Christiane Hermann , Jürgen Hoyer , Tina In-Albon , Tim Klucken , Gabriele Wilz\",\"doi\":\"10.1016/j.jad.2025.01.145\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Although meta-analyses suggest comparable efficacy of cognitive-behavioral therapy (CBT) in older adults compared to working-age adults, little is known about its effectiveness in naturalistic settings across different age groups. Hence, this study compared symptom change, attrition rates, and treatment duration in outpatient CBT between working-age adults (18–64 years), young-old adults (65–74 years), and old-old adults (≥ 75 years).</div></div><div><h3>Methods</h3><div>We analyzed a large naturalistic dataset comprising 9081 patients between 18 and 96 years receiving outpatient CBT in Germany. Using propensity score matching, we examined differences in treatment response, remission, attrition, and duration between comparable groups of working-age, young-old, and old-old adults.</div></div><div><h3>Results</h3><div>Response and remission rates did not differ between the three age groups in terms of the Brief Symptom Inventory (BSI-53) and patient- and clinician-rated subjective improvement (CGI-I). Young-old and old-old adults showed lower rates of response and remission on the Beck Depression Inventory (BDI-II). These differences were limited to items assessing somatization, which may be related to normal aging. Treatment duration was shorter in young-old and old-old adults compared to working-age adults. Attrition rates did not differ.</div></div><div><h3>Limitations</h3><div>The samples of older adults were relatively small and probably selective. Especially, home-bound, vulnerable older adults may be underrepresented. Further, the observational study design limits interpretability of findings.</div></div><div><h3>Conclusions</h3><div>Young-old and old-old adults seem to benefit from outpatient CBT to a similar extent as working-age adults. Potential bias in outcome measures due to age-related somatic complaints should be acknowledged in practice and future research.</div></div>\",\"PeriodicalId\":14963,\"journal\":{\"name\":\"Journal of affective disorders\",\"volume\":\"375 \",\"pages\":\"Pages 456-464\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of affective disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165032725001624\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165032725001624","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/29 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
How do young-old and old-old adults benefit from cognitive-behavioral therapy compared to working-age adults? A large multicenter naturalistic study
Background
Although meta-analyses suggest comparable efficacy of cognitive-behavioral therapy (CBT) in older adults compared to working-age adults, little is known about its effectiveness in naturalistic settings across different age groups. Hence, this study compared symptom change, attrition rates, and treatment duration in outpatient CBT between working-age adults (18–64 years), young-old adults (65–74 years), and old-old adults (≥ 75 years).
Methods
We analyzed a large naturalistic dataset comprising 9081 patients between 18 and 96 years receiving outpatient CBT in Germany. Using propensity score matching, we examined differences in treatment response, remission, attrition, and duration between comparable groups of working-age, young-old, and old-old adults.
Results
Response and remission rates did not differ between the three age groups in terms of the Brief Symptom Inventory (BSI-53) and patient- and clinician-rated subjective improvement (CGI-I). Young-old and old-old adults showed lower rates of response and remission on the Beck Depression Inventory (BDI-II). These differences were limited to items assessing somatization, which may be related to normal aging. Treatment duration was shorter in young-old and old-old adults compared to working-age adults. Attrition rates did not differ.
Limitations
The samples of older adults were relatively small and probably selective. Especially, home-bound, vulnerable older adults may be underrepresented. Further, the observational study design limits interpretability of findings.
Conclusions
Young-old and old-old adults seem to benefit from outpatient CBT to a similar extent as working-age adults. Potential bias in outcome measures due to age-related somatic complaints should be acknowledged in practice and future research.
期刊介绍:
The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.