Journal of affective disorders最新文献

{"title":"Correspondence to the Wu et al. vitamin C and suicidal ideation: A cross-sectional and Mendelian randomization study","authors":"Lingling Li , Xiaohui Liu , Tengfei Liu","doi":"10.1016/j.jad.2025.04.069","DOIUrl":"10.1016/j.jad.2025.04.069","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 390-391"},"PeriodicalIF":4.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A qualitative investigation of the modifiable determinants of medication adherence in bipolar disorder (BD): Views of patients and their family and friends","authors":"Asta Ratna Prajapati ,&nbsp;Sion Scott ,&nbsp;Alexandra L. Dima ,&nbsp;Allan Clark ,&nbsp;Jo Taylor ,&nbsp;Jonathan Wilson ,&nbsp;Debi Bhattacharya","doi":"10.1016/j.jad.2025.04.149","DOIUrl":"10.1016/j.jad.2025.04.149","url":null,"abstract":"<div><h3>Background</h3><div>Medication nonadherence in bipolar disorder (BD) can lead to adverse outcomes including relapse, hospitalisation and suicidility. Adherence research traditionally excludes mental health populations and their family and friends, contributing to inequity between physical and mental health. We used behavioural science to characterise modifiable adherence determinants in BD from the perspectives of patients and their family and friends.</div></div><div><h3>Method</h3><div>Between April-June 2020, we conducted two focus groups and 26 interviews with adults with BD and their family and friends. We explored modifiable adherence determinants which were mapped to the Theoretical Domains Framework (TDF), followed by a thematic analysis and prioritisation of determinants.</div></div><div><h3>Results</h3><div>Sixty-three (including 13 new) adherence determinants, mapped to nine TDF domains, were prioritised. Four themes of adherence determinants emerged: the medication itself; practicalities; how patients perceive themselves, their illness, and treatments; and collaboration between patients, their family and friends, and healthcare professionals. Nine prioritised TDF domains were: ‘Environmental context and resources’, ‘Intentions’, ‘Emotion’, ‘Social Influences’, ‘Goals’, ‘Memory, attention and decision processes’, ‘Beliefs about consequences’, ‘Knowledge’ and ‘Social/professional role and identity’. Respective examples include side effects, treatment preferences, fear of not being ‘myself’, relationships with healthcare team, medication affecting life goals, forgetfulness, beliefs about negative consequences, not knowing the risk of stopping medication, and involvement in treatment decisions.</div></div><div><h3>Conclusion</h3><div>Targeting antecedents of forgetfulness as well as newly identified determinants linked to ‘Emotion’ and ‘Intentions’, may improve adherence. Mapping adherence determinants to TDF domains provides a framework for designing personalised adherence interventions by selecting appropriate behaviour change techniques.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 462-470"},"PeriodicalIF":4.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency-specific network connectivity impairments linked to suicide attempts in major depressive disorder during the GO/NOGO task","authors":"Zhongpeng Dai ,&nbsp;Yi Xia ,&nbsp;Hongliang Zhou ,&nbsp;Zhilu Chen ,&nbsp;Rongxin Zhu ,&nbsp;Zhijian Yao ,&nbsp;Qing Lu","doi":"10.1016/j.jad.2025.04.081","DOIUrl":"10.1016/j.jad.2025.04.081","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) is a main risk factor of suicide, emphasizing the urgent need for understanding the neurobiological mechanisms underlying suicide attempts (SAs) in depressive patients. We hypothesized that aberrant frequency-specific functional connectivity patterns underlying an executive and inhibition task might be associated with SA in depression.</div></div><div><h3>Methods</h3><div>The current study enrolled 143 subjects including 43 healthy controls and 87 patients with MDD (43 patients with SA and 44 without SA), who attended a GO/NOGO task during the magnetoencephalography recording. Time-frequency features in the whole-brain sensors and frequency-specific brain network connectivity patterns were estimated. Behavioral data was recorded during the tasks and neurocognitive assessments were conducted.</div></div><div><h3>Results</h3><div>The SA group exhibited poorest behavioral and neurocognitive assessments performances. Decreased alpha/beta oscillations of the GO condition and increased alpha/beta oscillations of NOGO condition were observed in the SA group. Hypo-activated frontal-limbic connectivity in the alpha band and frontal-occipital connectivity in the beta band were observed in the SA group during the GO trials, meanwhile, hyper-activated frontal-temporal connectivity in the alpha band and frontal-parietal connectivity in the beta band were associated with SA during the NOGO trials. Frequency-specific features were correlated with the severity of suicide risk, neurocognitive assessments, and could be used to predict potential SAs.</div></div><div><h3>Conclusions</h3><div>Neuroimaging and neurocognitive evidences supported altered alpha/beta oscillations and connectivity patterns associated with SA in depression, suggesting that depressive patients with SA might exhibit impaired cognitive control functions.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 407-416"},"PeriodicalIF":4.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific expression and common potential therapeutic drugs in different brain regions of major depressive disorder patients: bioinformatics analysis","authors":"Nan Chen,&nbsp;Yong Luan","doi":"10.1016/j.jad.2025.04.140","DOIUrl":"10.1016/j.jad.2025.04.140","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is a prevalent and debilitating mental health condition characterized by persistent feelings of sadness and loss of interest. Despite its high prevalence, the underlying molecular mechanisms remain poorly understood. This study aims to elucidate the gene expression differences across distinct brain regions in MDD patients, identify potential diagnostic and therapeutic targets, and establish predictive models using bioinformatics approaches.</div><div>Whole-transcriptome sequencing data from three different human brain regions were obtained from five datasets (GSE54564, <span><span>GSE54571</span><svg><path></path></svg></span>, <span><span>GSE54572</span><svg><path></path></svg></span>, <span><span>GSE54567</span><svg><path></path></svg></span>, <span><span>GSE54568</span><svg><path></path></svg></span>) in the GEO database. Gene symbol preprocessing was conducted using the XIANTAO platform. Differentially expressed genes (DEGs) were identified between MDD samples and controls using the R package \"limma.\" Protein-protein interaction (PPI) networks were constructed using STRING and visualized in Cytoscape. Core genes were identified via CytoHubba using three algorithms (MCC, DEGREE, EPC). Receiver operating characteristic (ROC) curve analysis was performed to evaluate the prognostic value of core genes. LASSO regression was employed to enhance prediction accuracy and interpretability of machine learning models. Potential therapeutic drugs were predicted using the Comparative Toxicogenomics Database (CTD).</div><div>In total, 342 DEGs related to the amygdala, 76 DEGs related to the anterior cingulate cortex, and 64 DEGs related to the dorsolateral prefrontal cortex were identified (<em>p</em> &lt; 0.05, |logFC| &gt; 0.15). Key diagnostic genes included COX5A and SST for the amygdala; CTSG, IL18RAP, LMO2, and MS4A7 for the anterior cingulate cortex; and VGF for the dorsolateral prefrontal cortex. The machine learning models demonstrated high predictive accuracy with AUC values of 0.776 for the amygdala, 0.928 for the anterior cingulate cortex, and 0.867 for the dorsolateral prefrontal cortex. Potential therapeutic drugs included dorsomorphin and trichostatin A.</div><div>Gene set enrichment analysis (GSEA) revealed significant pathways such as oxidative phosphorylation in the amygdala, TYROBP microglial network in the anterior cingulate cortex, and MAPK signaling pathway in the dorsolateral prefrontal cortex.</div><div>This study provides a comprehensive bioinformatics analysis of gene expression differences across brain regions in MDD patients. The identified core genes and pathways offer valuable insights into disease mechanisms and potential therapeutic targets, paving the way for future clinical applications.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 478-487"},"PeriodicalIF":4.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics reveal the role of nociception-related genes TNXB, CTNND1 and CBL in depression","authors":"Qian Wu ,&nbsp;Dehui Lin ,&nbsp;Taishun Wang ,&nbsp;Weiyi Lin ,&nbsp;Shanze Wang ,&nbsp;Leixin Lai ,&nbsp;Minjun Xie ,&nbsp;Xiuyun Wen","doi":"10.1016/j.jad.2025.04.067","DOIUrl":"10.1016/j.jad.2025.04.067","url":null,"abstract":"<div><h3>Background</h3><div>Recent studies have suggested a link between nociception and depression. However, the specific genes involved remain unclear.</div></div><div><h3>Methods</h3><div>This study investigates this genetic link using multi-omics data. We collected nociception-related genes from the GeneCards database and integrated quantitative trait loci (mQTLs, eQTLs and pQTLs) data for gene expression, DNA methylation and protein expression. GWAS data from the IEU database served as the discovery cohort for depression, with FinnGen and GWAS Catalog data used for validation. Summary data-based Mendelian Randomization (SMR) analysis was employed to examine the interactions between nociception-related genes and depression, and colocalization analysis identified shared causal variants. The associations between depression and target gene expression in specific tissues and specific cell types were assessed using the GTEx v8 dataset and single-cell eQTL data.</div></div><div><h3>Results</h3><div>SMR analysis revealed 215 mQTLs, 12 eQTLs, and 1 pQTL associated with depression in the discovery cohort. By integrating multi-omics evidence, we found that the hypermethylation of the <em>TNXB</em> gene (cg02272968, cg02432444, cg27624229) and the hypomethylation of the <em>CTNND1</em> gene (cg16127573) and the <em>P2RY6</em> gene (cg12889420) were found to upregulate their expression, potentially increasing the risk of depression. GTEx eQTL analysis confirmed <em>CBL</em> expression in the substantia nigra positively correlates with depression risk. However, none of the key genes were confirmed in the single-cell eQTL analysis.</div></div><div><h3>Conclusions</h3><div>Our study emphasizes the importance of nociception-related genes, particularly <em>TNXB</em>, <em>CTNND1</em> and <em>CBL</em> in the pathogenesis of depression. Future research should build on these findings for potential prevention and treatment strategies.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 346-354"},"PeriodicalIF":4.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affective theory of mind impairments linked with callous-unemotional traits implicate cognitive control: A pre-registered double-blind randomized controlled trial with a dual-task paradigm","authors":"Drew E. Winters ,&nbsp;Juliet Spitz ,&nbsp;Kristen Raymond ,&nbsp;Crystal Natvig ,&nbsp;Rebecca Waller ,&nbsp;Susan K. Mikulich-Gilbertson ,&nbsp;Joseph T. Sakai","doi":"10.1016/j.jad.2025.04.154","DOIUrl":"10.1016/j.jad.2025.04.154","url":null,"abstract":"<div><h3>Introduction</h3><div>Youth antisocial behavior strongly associates with conduct problems (CP) and callous-unemotional (CU) traits. While CP has links to broad cognitive impairments, CU traits have specific links with cognitive control and affective theory of mind (ToM) difficulties. Evidence suggests cognitive control limitations impact affective processing in ToM amongst youth with elevated CU traits. Here we sought to improve on those initial findings by leveraging a randomized dual-task (within-trial) design to replicate and extend prior findings.</div></div><div><h3>Methods</h3><div>In this double-blind, randomized controlled trial, 85 participants (47 % female) were stratified by sex and CU trait severity. The study employed a ToM task with cognitive, affective, and physical conditions, combined with an inhibitory processing task to tax cognitive control. Participants completed single and dual-task trials, counterbalanced to test within-subject effects. Primary hypotheses were tested with both CP and CU traits in the same model using repeated measure mixed effects to examine changes in accuracy and reaction time.</div></div><div><h3>Results</h3><div>CU traits were uniquely associated with greater impairments in affective ToM under dual-task conditions, reflecting increased difficulty integrating affective information when cognitive demands were increased. CP associated with lower single ToM performance but no change during dual-task trials. Notably, participants resilient to dual-task effects reported fewer antisocial behaviors, even with elevated CU traits.</div></div><div><h3>Limitations</h3><div>While appropriately powered for study aims, the sample was underpowered to detect any potential primary and secondary variant interactions on study outcomes.</div></div><div><h3>Conclusions</h3><div>These findings support a CU trait specific cognitive-affective interaction as a mechanism critical for understanding youth antisocial behavior.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 417-427"},"PeriodicalIF":4.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of cranial electrotherapy stimulation for treating primary and secondary depression in adults: A meta-analysis of randomized controlled trials","authors":"Shu-Yen Liu ,&nbsp;Ruey Chen ,&nbsp;Chia-Hui Wang ,&nbsp;Kondwani Joseph Banda ,&nbsp;Chien-Mei Sung ,&nbsp;Li-Fang Chang ,&nbsp;Melati Fajarini ,&nbsp;Kuei-Ru Chou","doi":"10.1016/j.jad.2025.04.074","DOIUrl":"10.1016/j.jad.2025.04.074","url":null,"abstract":"<div><h3>Background</h3><div>Antidepressants use is linked to poor response, treatment discontinuation, and treatment-resistant depression. However, evidence regarding efficacy of cranial electrotherapy stimulation (CES) in treating depression is limited. Therefore, we conducted the first meta-analysis to explore efficacy of CES in treating primary and secondary depression in adults.</div></div><div><h3>Methods</h3><div>PubMed, Embase, CINAHL, Web of Science, EBSCOHost, and Cochrane Library were comprehensively searched. Dersimonian-Lard random-effects model in Comprehensive Meta-Analysis 4.0 was used, presenting Hedges’ <em>g</em> with corresponding 95 % confidence interval (CI) for depressive symptoms and Quality of life (QoL) while odds ratio (OR) for safety and acceptability of CES. Heterogeneity was examined using Cochrane’s <em>Q</em> and <em>I</em>² statistics with moderator analysis determining sources of variation.</div></div><div><h3>Results</h3><div>Sixteen randomized controlled trials involving 1148 adults were included. CES significantly reduced depressive symptoms with small effect (<em>g</em> = -0.33 [95%CI -0.46, -0.20]) compared to non-CES treatment; it was safe (OR = 0.84 [95%CI 0.32, 2.18]) and acceptable (OR = 0.72 [95%CI 0.41, 1.27]). CES revealed non-significant effect on improving QoL (<em>g</em> = 0.13 [95%CI -0.05, 0.31]). Substantial improvement of CES were observed for females (β = -0.010 [95%CI -0.019, -0.0003]), secondary depression (<em>g</em> = -0.42 [95%CI -0.58, -0.27]), current &gt;100 μA (<em>g</em> = -0.38 [95%CI -0.58, -0.18]), frequency &gt; 100 Hz (<em>g</em> = -0.50 [95%CI -0.81, -0.20]), length ≤ 30 min (<em>g</em> = -0.39 [95%CI -0.64, -0.14]), sessions/week ≤5times (<em>g</em> = -0.34 [95%CI -0.49, -0.19]), and duration ≤5 weeks (<em>g</em> = -0.45 [95%CI -0.63, -0.27]).</div></div><div><h3>Conclusions</h3><div>CES, a safe adjunctive therapy, demonstrates small effect in the treatment of depression. Future research should explore long-term effects of CES for treating adults with depression.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 488-497"},"PeriodicalIF":4.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cluster-specific urban contexts associated with high levels of sleep impairment and daytime sleepiness: Findings from the Urbasan collaborative study","authors":"Philippe Voruz ,&nbsp;Marco Vieira Ruas ,&nbsp;Noé Fellay ,&nbsp;Noemi Romano ,&nbsp;Michelangelo Mussini ,&nbsp;Mathieu Saubade ,&nbsp;Vincent Faivre ,&nbsp;Vincent Gremeaux ,&nbsp;Ophélia Jeanneret ,&nbsp;Quentin Tonnerre ,&nbsp;Marie-Noëlle Domon-Aubort ,&nbsp;Dario Spini ,&nbsp;Bengt Kayser ,&nbsp;Daniel Rappo ,&nbsp;Stéphane Joost","doi":"10.1016/j.jad.2025.04.133","DOIUrl":"10.1016/j.jad.2025.04.133","url":null,"abstract":"<div><h3>Introduction</h3><div>Impaired sleep is a global health concern. However, the environmental factors contributing to sleep impairment in urban settings are still not well understood.</div></div><div><h3>Methodology</h3><div>This study involved 179 participants from a Swiss municipality (Yverdon-les-Bains), where sleep quality and diurnal sleepiness were measured using validated questionnaires, alongside environmental and geo-referenced data.</div></div><div><h3>Results</h3><div>The findings revealed a high prevalence of sleep disorders across diverse demographic groups (respectively 15.6 % for diurnal sleepiness and 91.1 % for significantly altered sleep quality). Additionally, sleep disorders were associated with both environmental and socio-demographic factors. Geospatial analysis identified clusters of sleep disturbances in specific neighborhoods, with distinct associations to specific sub-scores (factors) of the sleep evaluation.</div></div><div><h3>Conclusion</h3><div>Assessing sleep in urban environments is crucial, as it is linked to elevated levels of sleepiness. Environmental and socio-demographic variables play significant roles in these disturbances. The incorporation of geospatial analyses allows for a more precise identification of patterns within the city, offering opportunities for tailored interventions to address the different patterns of sleep disorders.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 392-398"},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between triglyceride glucose index-related obesity indices and anxiety: Insights from the National Health and Nutrition Examination Survey 2007–2012","authors":"Yixi Wang ,&nbsp;Haimeng Wang,&nbsp;Bin Cheng,&nbsp;Juan Xia","doi":"10.1016/j.jad.2025.04.134","DOIUrl":"10.1016/j.jad.2025.04.134","url":null,"abstract":"<div><h3>Background</h3><div>The triglyceride glucose index (TyG), along with its associated obesity indices, including TyG-body mass index (TyG-BMI), TyG-waist-to-height ratio (TyG-WHtR), TyG-waist circumference (TyG-WC), and TyG-weight-adjusted-waist index (TyG-WWI), have become valuable tools for evaluating insulin resistance in metabolic diseases. Few researches explored their links with anxiety.</div></div><div><h3>Methods</h3><div>This observational study leveraged data from the National Health and Nutrition Examination Survey (2007-2012), analyzing 6726 participants to investigate the correlations between TyG-related indices and anxiety using multivariable logistic regression, subgroup analysis, and curve fitting.</div></div><div><h3>Results</h3><div>After adjusting for confounders, significant positive correlations were identified between TyG, TyG-WWI, and anxious days [0.792 (0.262, 1.322); 0.033 (0.003, 0.063)]. These findings were reinforced when TyG-related indices were categorized into quartiles. Positive associations were further observed between TyG and anxiety state [1.243 (1.076, 1.437)], which was consistent across quartile groupings. Subgroup analyses revealed that racial stratification significantly influenced the relationship between TyG, TyG-BMI, TyG-WHtR, TyG-WC, TyG-WWI and anxious days. Gender stratification significantly influenced the relationship between TyG and anxiety state. Linear associations were established between TyG and anxious days, anxiety state with regression coefficients of 0.873 and 1.254 respectively. Non-linear relationships and threshold effects were detected, with inflection points at 187.731, 3.040, 725.288, and 104.011 (for TyG-BMI, TyG-WHtR, TyG-WC, TyG-WWI with anxious days) and 188.677, 3.059, 730.251, and 103.869 (for TyG-BMI, TyG-WHtR, TyG-WC, TyG-WWI with anxiety state).</div></div><div><h3>Conclusions</h3><div>These results enhance our understanding of relationships between TyG-related indices and anxiety, providing valuable insights for the prevention and management of obesity and anxiety.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 443-452"},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain activation characteristics of schizophrenia and bipolar disorder-I patients during letter and category fluency tasks: An empirical study using functional near-infrared spectroscopy","authors":"Juan Li ,&nbsp;Haiyue Dai ,&nbsp;Mengmeng Zhang ,&nbsp;Yuening Li ,&nbsp;Guanqun Yao ,&nbsp;Zhaohui Zhang ,&nbsp;Juan Wang","doi":"10.1016/j.jad.2025.04.073","DOIUrl":"10.1016/j.jad.2025.04.073","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia (SP) and bipolar disorder type I (BD-I) are severe psychiatric disorders with partially overlapping clinical symptoms, resulting in difficult differential diagnosis in many cases. Therefore, objective markers are needed to ensure diagnostic accuracy and timely treatment. One strategy with the potential to provide disease markers for diagnosis and reveal potential pathogenic mechanisms is combined cognitive testing and neuroimaging. In the current study, we compared cortical activation patterns among SP, BD-I, and healthy control (HC) groups during verbal fluency tasks using functional near-infrared spectroscopy (fNIRS) to identify distinguishing biomarkers.</div></div><div><h3>Methods</h3><div>Sixty SP patients, 42 BD-I patients, and 44 age- and sex-matched HCs were examined by 52-channel fNIRS during the letter fluency task (LFT) and category fluency task (CFT).</div></div><div><h3>Results</h3><div>Both patient groups exhibited performance deficits in the LFT and even larger deficits in the CFT compared to HCs. Patients with SP and HCs exhibited greater prefrontal cortex activation during the CFT than the LFT. Compared to HCs, SP patients demonstrated reduced prefrontal cortex activation during both the CFT and LFT, especially in bilateral dorsolateral and ventrolateral areas. In contrast, BD-I patients showed reduced cortical activation only during the CFT, mainly in right frontal lobe and bilateral superior temporal cortex.</div></div><div><h3>Limitations</h3><div>Cross-section study design, small sample sizes, and uncontrolled effects of medication.</div></div><div><h3>Conclusions</h3><div>Patients with SP or BD-I exhibited pronounced semantic deficits and frontal-temporal dysfunction during CFT performance compared to HCs. These findings provide several potential markers for distinguishing SP from BD-I as well as clues to the underlying network-level pathology.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"382 ","pages":"Pages 471-477"},"PeriodicalIF":4.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}