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Diverging trends in alcohol-related harms: The role of comorbid mental health, suicide and self-harm behaviors in ambulance attendances for alcohol intoxication during the COVID-19 pandemic in Victoria, Australia. 与酒精有关的危害的不同趋势:澳大利亚维多利亚州 COVID-19 大流行期间,精神健康、自杀和自残行为在因酒精中毒而就诊的救护车中的作用。
IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-04 DOI: 10.1016/j.jad.2024.11.012
Rowan P Ogeil, Michael McGrath, Jasmin Grigg, Annette Peart, Jonathan Meddings, Christopher Greenwood, Ziad Nehme, Dan I Lubman

Background: Alcohol harms changed significantly during COVID-19, but did not affect the population equally. Vulnerable groups including people with pre-existing mental health or suicidal behaviors may be at greater risk of alcohol-related harms, yet limited public health data are able to assess these.

Methods: The present study utilised a novel, statewide surveillance system to examine ambulance attendances for alcohol intoxication over a four-year period prior to, and during the strictest lockdowns in Victoria, Australia.

Results: While there was an overall reduction in alcohol-related attendances during lockdown (n = 15,064) compared to the 2018-19 period (n = 16,989), alcohol- intoxication attendances involving mental health symptoms increased by 40 % in Melbourne (IRR: 1.40 [1.30-1.51], p < 0.001), and by 25 % in regional Victoria (IRR: 1.25 [1.07-1.44], p = 0.005).There was also a 7 % increase in alcohol-intoxication attendances with co-morbid suicidal behaviors in Melbourne (IRR: 1.07 95%CI [1.02-1.13], p = 0.006), and a 21 % increase in regional Victoria (IRR: 1.21 [1.08-1.35], p = 0.001).

Conclusions: These findings suggest that extra services and supports for individuals with co-morbid alcohol-related harms are required to ensure their clinical care needs are being met.

背景:在 COVID-19 期间,酒精危害发生了显著变化,但对人群的影响并不相同。包括已有心理健康或自杀行为的人群在内的弱势群体可能面临更大的酒精相关危害风险,但能够评估这些风险的公共卫生数据却很有限:本研究利用一个新颖的全州监测系统,对澳大利亚维多利亚州在最严格的禁酒令实施之前和实施期间的四年内因酒精中毒而就诊的救护车进行了检查:与 2018-19 年期间(n = 16989 人次)相比,封锁期间与酒精相关的就诊人数(n = 15064 人次)总体有所减少,但在墨尔本,涉及精神健康症状的酒精中毒就诊人数增加了 40%(IRR:1.40 [1.30-1.51],p):这些研究结果表明,需要为合并酒精相关伤害的患者提供额外的服务和支持,以确保满足他们的临床护理需求。
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引用次数: 0
Structural connectivity of thalamic subnuclei in major depressive disorder: An ultra-high resolution diffusion MRI study at 7-Tesla. 重度抑郁症丘脑下核的结构连接:7特斯拉超高分辨率弥散磁共振成像研究
IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-04 DOI: 10.1016/j.jad.2024.11.009
Weijian Liu, Jurjen Heij, Shu Liu, Luka Liebrand, Matthan Caan, Wietske van der Zwaag, Dick J Veltman, Lin Lu, Moji Aghajani, Guido van Wingen

Background: The thalamus serves as a central relay station within the brain, and thalamic connectional anomalies are increasingly thought to be present in major depressive disorder (MDD). However, the use of conventional MRI scanners and acquisition techniques has prevented a thorough examination of the thalamus and its subnuclear connectional profile. We combined ultra-high field diffusion MRI acquired at 7.0 Tesla to map the white matter connectivity of thalamic subnuclei.

Methods: Fifty-three MDD patients and 12 healthy controls (HCs) were involved in the final analysis. FreeSurfer was used to segment the thalamic subnuclei, and MRtrix was used to perform the preprocessing and tractography. Fractional anisotropy, axial diffusivity, mean diffusivity, radial diffusivity, and streamline count of thalamic subnuclear tracts were measured as proxies of white matter microstructure. Bayesian multilevel model was used to assess group differences in white matter metrics for each thalamic subnuclear tract and the association between these white matter metrics and clinical features in MDD.

Results: Evidence was found for reduced whiter matter metrics of the tracts spanning from all thalamic subnuclei among MDD versus HC participants. Moreover, evidence was found that white matter in various thalamic subnuclear tracts is related to medication status, age of onset and recurrence in MDD.

Conclusions: Structural connectivity was generally reduced in thalamic subnuclei in MDD participants. Several clinical characteristics are related to perturbed subnuclear thalamic connectivity with cortical and subcortical circuits that govern sensory processing, emotional function, and goal-directed behavior.

背景:丘脑是大脑的中央中继站,越来越多的人认为重度抑郁障碍(MDD)患者会出现丘脑连接异常。然而,传统核磁共振成像扫描仪和采集技术的使用阻碍了对丘脑及其核下连接特征的彻底检查。我们结合在 7.0 特斯拉下获得的超高场弥散核磁共振成像来绘制丘脑亚核的白质连接图:方法:53 名 MDD 患者和 12 名健康对照者(HCs)参与了最终分析。FreeSurfer用于丘脑亚核的分割,MRtrix用于进行预处理和牵引成像。测量丘脑亚核束的分数各向异性、轴向扩散率、平均扩散率、径向扩散率和流线数,作为白质微观结构的代用指标。贝叶斯多层次模型用于评估丘脑各亚核束白质指标的组间差异,以及这些白质指标与 MDD 临床特征之间的关联:结果:有证据表明,MDD参与者与HC参与者相比,所有丘脑亚核束的白质指标均有所降低。此外,有证据表明丘脑各亚核束的白质与药物治疗状态、发病年龄和 MDD 复发率有关:结论:多发性硬化症患者丘脑亚核的结构连接性普遍降低。一些临床特征与丘脑亚核与皮层和皮层下环路的连接紊乱有关,而皮层和皮层下环路控制着感觉处理、情绪功能和目标导向行为。
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引用次数: 0
Association between suicidal ideation and oxidative balance score (OBS): National Health and Nutrition Examination Survey (NHANES) 2005-2018. 自杀倾向与氧化平衡评分(OBS)之间的关系:美国国家健康与营养调查(NHANES)2005-2018。
IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-04 DOI: 10.1016/j.jad.2024.11.010
Xinyu Zhang, Hangyu Liu, Chu Mi, Jieshen Mao, Dahong Zhang, Haibin Wei

Background: The oxidative balance score (OBS) serves as an indicator of systemic oxidative stress status, where a higher OBS indicates significant exposure to antioxidants through dietary and lifestyle choices. Studies exploring the relationship between OBS and suicidal ideation are limited. Therefore, this study aimed to examine the association between OBS and suicidal ideation.

Methods: This cross-sectional study selected 28,598 individuals aged ≥20 years from the 2005-2018 National Health and Nutrition Examination Survey dataset. The OBS was determined using 16 dietary components and 4 lifestyle components. Item 9 of the Patient Health Questionnaire-9 was used to evaluate suicidal ideation. The association between suicidal ideation and OBS, dietary OBS, and lifestyle OBS was examined using weighted logistic regression and restricted cubic spline. The subgroup analyses and interaction tests were further conducted to assess the robustness of these associations across different populations.

Results: The prevalence of suicidal ideation was 3.35 %. OBS, dietary OBS, and lifestyle OBS were substantially and inversely linked with suicidal ideation in Models 1, 2, and 3 (P < 0.05). The odds ratio for the highest quartile of these variables and suicidal ideation in Model 3 was 0.44 [95 % confidence interval (CI): 0.30-0.65], 0.54 (95 % CI: 0.37-0.78), and 0.50 (95 % CI, 0.34-0.74), respectively, compared with the lowest quartile. The subgroup analyses revealed consistent connections between the three oxidative stress indices and suicidal ideation. The lifestyle OBS was negatively correlated with suicidal ideation, especially in women (P for interaction <0.05).

Conclusions: The dietary and lifestyle OBSs may influence suicidal ideation by modulating oxidative balance. An antioxidant diet and lifestyle are crucial in mitigating suicidal ideation. These findings suggest a potential sex-specific suicide ideation risk, which significantly correlates with suicidal ideation in women but not in men.

背景:氧化平衡评分(OBS)是衡量全身氧化应激状态的指标,OBS 越高,表明通过饮食和生活方式的选择接触抗氧化剂的机会越多。探讨 OBS 与自杀意念之间关系的研究十分有限。因此,本研究旨在探讨OBS与自杀意念之间的关系:这项横断面研究从 2005-2018 年全国健康与营养调查数据集中选取了 28,598 名年龄≥20 岁的人。采用 16 种饮食成分和 4 种生活方式成分确定 OBS。患者健康问卷-9的第9项用于评估自杀意念。采用加权逻辑回归和限制性立方样条法检验了自杀意念与OBS、饮食OBS和生活方式OBS之间的关联。为了评估这些关联在不同人群中的稳健性,还进一步进行了亚组分析和交互检验:结果:自杀意念的发生率为 3.35%。在模型 1、2 和 3 中,OBS、膳食 OBS 和生活方式 OBS 与自杀意念有显著的反向联系(P 结论:膳食 OBS 和生活方式 OBS 与自杀意念有显著的反向联系:饮食和生活方式中的 OBS 可通过调节氧化平衡来影响自杀意念。抗氧化饮食和生活方式对减轻自杀意念至关重要。这些研究结果表明,潜在的自杀意念风险具有性别特异性,女性的自杀意念与之显著相关,而男性则不然。
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引用次数: 0
Pathways linking loneliness and depressive symptoms among Chinese adolescents: The mediating role of sleep disturbance. 中国青少年孤独感与抑郁症状之间的联系途径:睡眠障碍的中介作用
IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-04 DOI: 10.1016/j.jad.2024.11.006
Huiyu Cheng, Wanting Hu, Shengyu Luo, Xiangyu Feng, Zijie Chen, Xiangyue Yu, Huijun Li, Xiuqiong Feng, Weiqing Chen, Vivian Yawei Guo

Background: Despite growing evidence linking loneliness and depressive symptoms, the underlying pathways remain unclear. This study aims to assess the impact of loneliness on depressive symptoms among Chinese adolescents and investigate the potential mediating role of sleep disturbance.

Methods: A cross-sectional study was conducted between November and December 2021. Loneliness, depressive symptoms, and sleep disturbance were assessed using the UCLA Loneliness Scale, the 9-item Patient Health Questionnaire, and the Pittsburgh Sleep Quality Index questionnaire, respectively. Baron and Kenny's causal steps method and the Karlson-Holm-Breen method were applied to explore the mediating role of sleep disturbance. Subgroup analysis by gender was also conducted.

Results: A total of 6838 adolescents were included, with 52.2 % boys and a mean age of 14.5 (SD = 1.6) years. Approximately 15.8 % of the adolescents reported depressive symptoms. Loneliness was positively associated with depressive symptoms after controlling for covariates (OR = 1.34, 95%CI = 1.31-1.36). After incorporating sleep disturbance into the model, the association was still significant (OR = 1.28, 95%CI = 1.25-1.31). Sleep disturbance partially mediated this association, contributing to 18.89 % of the total effects. The associations and mediation effects were consistent across both genders, with no moderating effect of gender observed.

Limitations: The cross-sectional design limits the ability to establish causality.

Conclusion: Loneliness was significantly associated with depressive symptoms in Chinese adolescents and this association was partially mediated by sleep disturbance. Interventions aimed at reducing loneliness and improving sleep quality may help lower the risk of depressive symptoms in Chinese adolescents, regardless of genders. Nevertheless, further randomized controlled trials are needed to confirm these findings.

背景:尽管越来越多的证据表明孤独感与抑郁症状有关,但其背后的途径仍不清楚。本研究旨在评估孤独感对中国青少年抑郁症状的影响,并探讨睡眠障碍的潜在中介作用:方法:2021年11月至12月期间进行了一项横断面研究。孤独感、抑郁症状和睡眠障碍分别通过加州大学洛杉矶分校孤独感量表、9项患者健康问卷和匹兹堡睡眠质量指数问卷进行评估。巴伦和肯尼的因果步骤法以及卡尔森-霍尔姆-布林法被用来探讨睡眠障碍的中介作用。研究还按性别进行了分组分析:共纳入了 6838 名青少年,其中男生占 52.2%,平均年龄为 14.5 岁(SD = 1.6)。约 15.8% 的青少年报告了抑郁症状。在控制协变量后,孤独感与抑郁症状呈正相关(OR = 1.34,95%CI = 1.31-1.36)。在将睡眠障碍纳入模型后,这种关联仍然显著(OR = 1.28,95%CI = 1.25-1.31)。睡眠障碍对这一关联起到了部分中介作用,占总效应的 18.89%。两性之间的关联和中介效应是一致的,没有观察到性别的调节效应:局限性:横断面设计限制了确定因果关系的能力:结论:孤独感与中国青少年的抑郁症状有明显的关联,这种关联部分受睡眠障碍的影响。旨在减少孤独感和改善睡眠质量的干预措施可能有助于降低中国青少年(无论性别)出现抑郁症状的风险。不过,还需要进一步的随机对照试验来证实这些发现。
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引用次数: 0
Joint effect of polysocial risk score, lifestyle and genetic susceptibility with the risk of dementia: A prospective cohort study. 多重社会风险评分、生活方式和遗传易感性对痴呆症风险的共同影响:一项前瞻性队列研究。
IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-04 DOI: 10.1016/j.jad.2024.11.005
Lichao Yang, Ziqing Sun, Qida He, Maosheng Zhu, Mengtong Sun, Hanqing Zhao, Yu Wang, Jianing Li, Yujie Shi, Zexin Lou, Boyan Liu, Miao Jiang, Yueping Shen

Objectives: The comprehensive impact of polysocial risk score (PsRS)-encompassing multiple social determinants of health (SDoHs) with genetic and lifestyle factors on dementia incidence remains to be elucidated.

Study design: This study aimed to clear the associations between PsRS and dementia incidence and evaluated how genetic and lifestyle factors modified these associations in the UK Biobank cohort.

Methods: The detailed prospective study involved over 500,000 participants when recruited in 2006-2010. The PsRS was calculated by 12 SDoHs across psychosocial factors, socioeconomic status, and neighborhood and living environment. A healthy lifestyle score was constructed from physical activities, alcohol consumption, smoking status, and diet. A genetic risk score (GRS) was computed via genotype data from UK Biobank. The Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the association between PsRS, lifestyle factors, GRS and dementia.

Results: Results showed the participants with intermediate (HR = 1.32, 95%CI: 1.20-1.45) and high PsRS (HR = 2.10, 95 % CI: 1.91-2.32) were significantly associated with an increased risk of dementia compared with those with a low PsRS. Then, compared with participants with low PsRS and favorable lifestyle/low GRS, high PsRS and unfavorable lifestyle/high GRS had the highest risk of dementia (HR = 3.11,95%CI: 2.63-3.68)/(HR = 3.56, 95%CI: 2.62-4.85).

Conclusions: Both high PsRS and GRS were significantly associated with higher dementia risk. A favorable lifestyle could reduce dementia incidence regardless of high PsRS or GRS. Additionally, focusing on the intervention of SDoHs would be positive in preventing dementia.

目的:多社会风险评分(PsRS)包含多种社会健康决定因素(SDoHs)以及遗传和生活方式因素,其对痴呆症发病率的综合影响仍有待阐明:本研究旨在明确PsRS与痴呆症发病率之间的关联,并评估遗传和生活方式因素如何改变英国生物库队列中的这些关联:这项详细的前瞻性研究涉及 2006-2010 年招募的 50 多万名参与者。PsRS由12个SDoHs计算得出,涉及社会心理因素、社会经济地位、邻里关系和生活环境。健康生活方式评分由体育活动、饮酒量、吸烟状况和饮食构成。遗传风险评分(GRS)是通过英国生物库的基因型数据计算得出的。采用 Cox 比例危险模型估算了 PsRS、生活方式因素、GRS 和痴呆症之间的危险比(HRs)和 95% 的置信区间(CIs):结果显示,与低PsRS参与者相比,中等PsRS参与者(HR=1.32,95%CI:1.20-1.45)和高PsRS参与者(HR=2.10,95%CI:1.91-2.32)患痴呆症的风险显著增加。然后,与PsRS低且生活方式良好/GRS低的参与者相比,PsRS高且生活方式不利/GRS高的参与者患痴呆症的风险最高(HR = 3.11,95%CI:2.63-3.68)/(HR = 3.56,95%CI:2.62-4.85):高PsRS和高GRS都与痴呆症的高风险显著相关。无论PsRS或GRS是否偏高,良好的生活方式都能降低痴呆症的发病率。此外,重点干预 SDoHs 对预防痴呆症也有积极意义。
{"title":"Joint effect of polysocial risk score, lifestyle and genetic susceptibility with the risk of dementia: A prospective cohort study.","authors":"Lichao Yang, Ziqing Sun, Qida He, Maosheng Zhu, Mengtong Sun, Hanqing Zhao, Yu Wang, Jianing Li, Yujie Shi, Zexin Lou, Boyan Liu, Miao Jiang, Yueping Shen","doi":"10.1016/j.jad.2024.11.005","DOIUrl":"https://doi.org/10.1016/j.jad.2024.11.005","url":null,"abstract":"<p><strong>Objectives: </strong>The comprehensive impact of polysocial risk score (PsRS)-encompassing multiple social determinants of health (SDoHs) with genetic and lifestyle factors on dementia incidence remains to be elucidated.</p><p><strong>Study design: </strong>This study aimed to clear the associations between PsRS and dementia incidence and evaluated how genetic and lifestyle factors modified these associations in the UK Biobank cohort.</p><p><strong>Methods: </strong>The detailed prospective study involved over 500,000 participants when recruited in 2006-2010. The PsRS was calculated by 12 SDoHs across psychosocial factors, socioeconomic status, and neighborhood and living environment. A healthy lifestyle score was constructed from physical activities, alcohol consumption, smoking status, and diet. A genetic risk score (GRS) was computed via genotype data from UK Biobank. The Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the association between PsRS, lifestyle factors, GRS and dementia.</p><p><strong>Results: </strong>Results showed the participants with intermediate (HR = 1.32, 95%CI: 1.20-1.45) and high PsRS (HR = 2.10, 95 % CI: 1.91-2.32) were significantly associated with an increased risk of dementia compared with those with a low PsRS. Then, compared with participants with low PsRS and favorable lifestyle/low GRS, high PsRS and unfavorable lifestyle/high GRS had the highest risk of dementia (HR = 3.11,95%CI: 2.63-3.68)/(HR = 3.56, 95%CI: 2.62-4.85).</p><p><strong>Conclusions: </strong>Both high PsRS and GRS were significantly associated with higher dementia risk. A favorable lifestyle could reduce dementia incidence regardless of high PsRS or GRS. Additionally, focusing on the intervention of SDoHs would be positive in preventing dementia.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between asthma and suggested alcohol dependence and heavy alcohol use in the Cooper Center longitudinal study: The role of depressive symptom severity. 库珀中心纵向研究中哮喘与酒精依赖和大量饮酒之间的关系:抑郁症状严重程度的作用。
IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-04 DOI: 10.1016/j.jad.2024.11.004
Catherine D Agarwal, Kerem Shuval, Qing Li, Laura F DeFina, Carolyn E Barlow, David A Khan, E Sherwood Brown

Background: Asthma appears to be associated with a variety of psychiatric illnesses including depression and alcohol use disorder. The current study examined the relationship between asthma, heavy alcohol intake and suggested alcohol dependence controlling for depressive symptom severity.

Methods: Data from 33,253 adult patients at the Cooper Clinic who enrolled in the Cooper Center Longitudinal Study, completed a medical history questionnaire including information on asthma, depressive symptoms and alcohol use were used. The association between lifetime asthma and heavy alcohol intake, while accounting for depressive symptoms (10-item Center for Epidemiological Studies-Depression (CESD)), and demographic variables was examined employing logistic regression with heavy alcohol intake (yes/no) as the outcome. Logistic regression was similarly utilized to examine the association between asthma and suggested alcohol dependence (CAGE scores ≥2: yes/no) among current drinkers (n = 26,028).

Results: Multivariable analysis revealed no significant association between asthma and heavy alcohol consumption with or without controlling for CES-D scores. Asthma was, however, associated with higher odds for suggested alcohol dependence (OR 1.18, CI 1.07, 1.31), which was attenuated but still significant when controlling for CES-D scores.

Conclusion: Asthma was associated with higher risk for suggested alcohol dependence while current heaving drinking risk was not increased. The suggested drinking findings were slightly less strong when controlling for CES-D scores. The differences between current heavy drinking and CAGE findings might be due to differences in perception of problematic drinking by people with asthma or the timeframe of the assessments (current for drinking, lifetime for CAGE).

背景:哮喘似乎与包括抑郁症和酒精使用障碍在内的多种精神疾病有关。本研究探讨了哮喘、大量酒精摄入和酒精依赖之间的关系,并对抑郁症状的严重程度进行了控制:研究使用了库珀诊所 33253 名成年患者的数据,这些患者参加了库珀中心纵向研究,并填写了病史问卷,其中包括哮喘、抑郁症状和饮酒情况。在考虑抑郁症状(10 个项目的流行病学研究中心抑郁症(CESD))和人口统计学变量的情况下,采用逻辑回归法,以大量饮酒(是/否)为结果,研究了终生哮喘与大量饮酒之间的关系。同样,我们还利用逻辑回归分析了当前饮酒者(n = 26,028)中哮喘与酒精依赖(CAGE评分≥2:是/否)之间的关系:结果:多变量分析表明,无论是否控制 CES-D 评分,哮喘与大量饮酒之间均无明显关联。然而,哮喘与较高的酒精依赖几率有关(OR 1.18,CI 1.07,1.31),在控制 CES-D 评分后,这种关系有所减弱,但仍有意义:结论:哮喘与较高的酒精依赖风险有关,而目前酗酒的风险并没有增加。结论:哮喘与较高的酒精依赖风险相关,而当前大量饮酒的风险并不增加。当前大量饮酒与 CAGE 评估结果之间的差异可能是由于哮喘患者对饮酒问题的认识不同或评估的时间范围不同(当前大量饮酒为当前评估,CAGE 为终生评估)。
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引用次数: 0
Interaction among negative mood, sleep, and diet habits in adolescents with non-suicidal self-injury: A cross-sectional network analysis. 非自杀性自伤青少年的负面情绪、睡眠和饮食习惯之间的相互作用:横断面网络分析
IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-03 DOI: 10.1016/j.jad.2024.11.007
Yunxiao Liu, Yating Yang, Ruitong Li, Qingqing Shen, Xiaoping Yuan, Jingwen Shang, Huanzhong Liu

Background: Non-suicidal self-injury (NSSI) is a serious public health problem that can lead to adverse effects such as cognitive impairment, poor interpersonal relationships and violent crime. The progress of preventing and treating NSSI in adolescents depends on other changeable risk factors, such as negative mood, sleep, and diet habits. However, the risk factors for adolescent NSSI remain unclear. Therefore, this study explores the key factors influencing adolescents' non-suicidal self-injurious behavior through the use of network analysis.

Methods: The study recruited 4040 middle school students aged 12-18 years old. From November 1st, 2023 to January 1st, 2024, paper questionnaires were utilized to investigate the participants' basic conditions, negative mood, NSSI, sleep conditions, and diet habits. Network analysis was used to explore the interrelationship among risk factors and discover the core factors.

Results: In the network structure of adolescents with NSSI behavior, the most correlated nodes were negative emotions (CDI2) and low self-esteem (CDI3). Compared with adolescents without NSSI behavior, adolescents with NSSI behavior showed prominent anxiety symptoms related to injury avoidance (MASC1) and social anxiety (MASC2). Anhedonia (CDI1) was both the central node and the bridge node of the network.

Limitation: The cross-sectional design of this study couldn't clarify the causal inference between independent variables and results.

Conclusion: Anhedonia is the key factor affecting adolescents' emotion regulation. Furthermore, we hypothesize that adolescent non-suicidal self-injury is an emotional disorder, and anhedonia plays an important role in preventing and intervening in adolescent non-suicidal self-injury behavior.

背景:非自杀性自伤(NSSI)是一个严重的公共卫生问题,可导致认知障碍、人际关系不良和暴力犯罪等不良后果。预防和治疗青少年 NSSI 的进展取决于其他可改变的风险因素,如负面情绪、睡眠和饮食习惯。然而,青少年 NSSI 的风险因素仍不明确。因此,本研究通过网络分析法探讨影响青少年非自杀性自残行为的关键因素:本研究招募了 4040 名 12-18 岁的中学生。从 2023 年 11 月 1 日至 2024 年 1 月 1 日,利用纸质问卷调查了参与者的基本情况、消极情绪、NSSI、睡眠状况和饮食习惯。采用网络分析法探讨危险因素之间的相互关系,发现核心因素:在有 NSSI 行为的青少年的网络结构中,最相关的节点是消极情绪(CDI2)和自卑(CDI3)。与无 NSSI 行为的青少年相比,有 NSSI 行为的青少年表现出的焦虑症状主要与避免受伤(MASC1)和社交焦虑(MASC2)有关。失乐症(CDI1)既是网络的中心节点,也是网络的桥梁节点:本研究的横断面设计无法明确自变量与结果之间的因果关系:失乐症是影响青少年情绪调节的关键因素。此外,我们假设青少年非自杀性自伤是一种情绪障碍,而失乐症在预防和干预青少年非自杀性自伤行为中发挥着重要作用。
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引用次数: 0
Cognition-related connectome gradient dysfunctions of thalamus and basal ganglia in drug-naïve first-episode major depressive disorder. 与认知相关的丘脑和基底神经节梯度功能障碍在初次服药的重度抑郁症患者中的表现。
IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-03 DOI: 10.1016/j.jad.2024.11.003
Qian Zhang, Aoxiang Zhang, Ziyuan Zhao, Qian Li, Yongbo Hu, Xiaoqi Huang, Weihong Kuang, Youjin Zhao, Qiyong Gong

Background: Subcortical functional abnormalities are believed to contribute to clinical symptoms and cognitive impairments in major depressive disorder (MDD). By introducing functional gradient mapping, the present study evaluated subcortical gradients in MDD patients and their association with cognitive features.

Methods: Organization patterns and between-group differences in the principal subcortical gradient were investigated in 145 never-treated first-episode MDD patients and 145 healthy controls (HCs) across limbic, thalamic, and basal ganglia (BG) systems and their structural and functional subregions. We also assessed the associations between significant gradient alterations and clinical characteristics and neuropsychological functioning.

Results: Overall, MDD patients showed a relatively compressed and disturbed gradient organization than HCs, with limbic and BG regions located at the two extreme ends of the principal gradient. Specifically, MDD patients had lower principal gradient values in thalamus and limbic system but higher values in BG than HCs. These gradient alterations, associated with intrinsic Euclidian distance and functional connectivity patterns, manifested as spatial rearrangements of gradient values within each respective subregion. Lower gradient values in thalamic subregion projecting to default mode network were associated with higher principal gradient values in BG subregion projecting to ventral attention network, and these gradient alterations were correlated with poorer episodic memory performance in MDD patients.

Limitations: The specific neuropathological mechanisms driving the gradient alterations still require further investigation.

Conclusions: Opposing gradient alterations in the thalamic and BG regions synergistically impact episodic memory performance in MDD, revealing an internally differentiated and cognition related pattern of subcortical gradient dysfunction in MDD.

背景:皮层下功能异常被认为是导致重度抑郁症(MDD)临床症状和认知障碍的原因之一。通过引入功能梯度图,本研究评估了MDD患者的皮层下梯度及其与认知特征的关联:方法:研究了145名从未接受过治疗的首次发病的MDD患者和145名健康对照组(HCs)的边缘、丘脑和基底节(BG)系统及其结构和功能亚区的主要皮层下梯度的组织模式和组间差异。我们还评估了显著梯度改变与临床特征和神经心理功能之间的关联:总体而言,MDD患者的梯度组织比HC患者相对压缩和紊乱,边缘和BG区域位于主梯度的两端。具体来说,与普通人相比,MDD 患者丘脑和边缘系统的主梯度值较低,但 BG 的主梯度值较高。这些梯度变化与内在欧几里得距离和功能连接模式有关,表现为每个亚区域内梯度值的空间重新排列。投射到默认模式网络的丘脑亚区的梯度值较低,而投射到腹侧注意网络的BG亚区的主梯度值较高,这些梯度改变与MDD患者较差的外显记忆表现相关:局限性:驱动梯度改变的具体神经病理学机制仍需进一步研究:丘脑和BG区域相互对立的梯度改变协同影响了MDD患者的外显记忆能力,揭示了MDD患者皮层下梯度功能障碍的内部分化和认知相关模式。
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引用次数: 0
Efficacy and safety of low-frequency repetitive transcranial magnetic stimulation in adolescents with first-episode major depressive disorder: A randomized, double-blind, sham-controlled pilot trial. 低频重复经颅磁刺激对初发重度抑郁障碍青少年的疗效和安全性:随机、双盲、假对照试验。
IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-02 DOI: 10.1016/j.jad.2024.11.001
Li-Mei Gu, Can-Jin Deng, De-Wei Shang, Shan-Qing Huang, Sha Nie, Xin-Hu Yang, Yu-Ping Ning, Xing-Bing Huang, Lloyd Balbuena, Yu-Tao Xiang, Wei Zheng

Background: A few sham-controlled studies have examined the efficacy, safety, and tolerability of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) in adolescents with first-episode major depressive disorder (FE-MDD).

Methods: Forty adolescents (aged 13-17 years) with FE-MDD were randomly assigned to receive active rTMS (n = 20) or sham rTMS (n = 20) for 10 sessions over two weeks. The severity of baseline depressive symptoms and their improvement on the day immediately after the second, fourth, sixth, eighth, and tenth sessions were assessed with the 17-item Hamilton Depression Rating Scale (HAMD-17).

Results: After completing 10 rTMS treatment sessions, there was no significant difference in antidepressant response (70.0 % vs. 60.0 %, p > 0.05) and antidepressant remission (55.0 % vs. 35.0 %, p > 0.05) between rTMS groups. The linear mixed model analysis did not show a significant group-by-time interaction (F = 1.26; p > 0.05) in the HAMD-17 scores. There was a significant time main effect on the speed of processing (F = 13.61; p < 0.05), but this did not differ significantly between groups (p > 0.05). There were no other main effects and group-by-time interactions in the other MATRICS Consensus Cognitive Battery domains (all p > 0.05). All adverse event categories, such as fatigue and headache, were similar in the two groups (all p > 0.05).

Conclusions: In this study that compared a combination of LF-rTMS + medication with sham + medication, LF-rTMS had higher response and remission rates than a sham procedure in adolescents with FE-MDD, but the change was not statistically significant. LF-rTMS is generally safe, with mild adverse effects and no negative impact on neurocognitive performance for adolescents with FE-MDD.

Registration number: ChiCTR2000037878.

背景:一些假对照研究考察了低频重复经颅磁刺激(LF-rTMS)对首发重度抑郁障碍(FE-MDD)青少年的疗效、安全性和耐受性:40名患有FE-MDD的青少年(13-17岁)被随机分配到接受主动经颅磁刺激(20人)或假经颅磁刺激(20人),为期两周,共10次。用汉密尔顿抑郁评定量表(HAMD-17)的17个项目评估基线抑郁症状的严重程度以及在第二、第四、第六、第八和第十次治疗后第二天的改善情况:在完成10次经颅磁刺激治疗后,经颅磁刺激治疗组之间的抗抑郁反应(70.0% vs. 60.0%,P > 0.05)和抗抑郁缓解(55.0% vs. 35.0%,P > 0.05)无显著差异。线性混合模型分析表明,HAMD-17 评分并不存在显著的组间时间交互作用(F = 1.26;P > 0.05)。处理速度的时间主效应非常明显(F = 13.61;P 0.05)。在 MATRICS 共识认知电池的其他领域中,没有其他主效应和组间时间交互作用(所有 p > 0.05)。所有不良事件类别,如疲劳和头痛,在两组中相似(所有 p > 0.05):结论:本研究比较了LF-经颅磁刺激+药物治疗与假治疗+药物治疗的组合,在患有FE-MDD的青少年中,LF-经颅磁刺激的反应率和缓解率均高于假治疗,但差异无统计学意义。对于患有FE-MDD的青少年来说,LF-rTMS总体上是安全的,不良反应轻微,对神经认知表现没有负面影响:注册号:ChiCTR2000037878。
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引用次数: 0
Deciphering the genetic underpinnings of neuroticism: A Mendelian randomization study of druggable gene targets. 解密神经质的遗传基础:可药用基因靶点的孟德尔随机化研究。
IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-11-02 DOI: 10.1016/j.jad.2024.11.002
Yanggang Hong, Yi Wang, Wanyi Shu

Background: Neuroticism, known for its association with a greater risk of psychiatric conditions such as depression and anxiety, is a critical focus of research.

Methods: Cis-expression quantitative trait loci (eQTLs) from 31,684 whole blood samples provided by the eQTLGen Consortium, alongside data from a large neuroticism cohort, were analyzed to identify genes causally linked to neuroticism. To further explore the influence of gene expression changes on neuroticism, colocalization analysis was conducted. Identified drug targets were assessed for potential side effects using a phenome-wide association study (PheWAS). Additionally, we utilized multiple databases to explore the interactions between drugs and genes for drug prediction and assess the current medications for drug repurposing.

Results: The analysis involved a total of 4473 druggable genes, with two-sample Mendelian randomization (MR) identifying 186 genes that are causally linked to neuroticism. Colocalization analysis highlighted 11 genes (TLR4, MMRN1, EP300, BRAF, ORM1, ACVR1B, LRRC17, NOS2, ADAMTS6, GPX1, and VCL) with a posterior probability of colocalization (PPH4) >0.8. PheWAS revealed that drugs targeting BRAF, LRRC17, ADAMTS6, and GPX1 were also associated with other traits. Notably, six of these genes (TLR4, MMRN1, BRAF, ACVR1B, NOS2, and GPX1) are already being explored for drug development in psychiatric and other diseases.

Conclusion: This study pinpointed six genes as promising therapeutic targets for neuroticism. The repurposing and development of drugs targeting these genes hold potential for managing neuroticism and associated psychiatric disorders.

背景:神经质与抑郁和焦虑等精神疾病的高风险有关,是研究的一个重要焦点:方法:分析了由 eQTLGen 联合会提供的 31,684 份全血样本中的顺式表达定量性状位点(eQTLs)以及来自大型神经质队列的数据,以确定与神经质有因果关系的基因。为了进一步探索基因表达变化对神经质的影响,还进行了共定位分析。利用全表型关联研究(PheWAS)评估了已确定的药物靶点的潜在副作用。此外,我们还利用多个数据库探索药物与基因之间的相互作用,以进行药物预测,并评估目前的药物再利用:分析共涉及 4473 个可用药基因,通过双样本孟德尔随机化(MR)确定了 186 个与神经质有因果关系的基因。共定位分析显示,11个基因(TLR4、MMRN1、EP300、BRAF、ORM1、ACVR1B、LRRC17、NOS2、ADAMTS6、GPX1和VCL)的共定位后验概率(PPH4)大于0.8。PheWAS显示,针对BRAF、LRRC17、ADAMTS6和GPX1的药物也与其他性状相关。值得注意的是,其中六个基因(TLR4、MMRN1、BRAF、ACVR1B、NOS2 和 GPX1)已被用于精神疾病和其他疾病的药物开发:结论:本研究确定了六个基因作为神经质的治疗靶点。结论:本研究将六个基因确定为治疗神经质的有希望的靶点,针对这些基因的药物的再利用和开发为治疗神经质和相关精神疾病提供了可能。
{"title":"Deciphering the genetic underpinnings of neuroticism: A Mendelian randomization study of druggable gene targets.","authors":"Yanggang Hong, Yi Wang, Wanyi Shu","doi":"10.1016/j.jad.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.jad.2024.11.002","url":null,"abstract":"<p><strong>Background: </strong>Neuroticism, known for its association with a greater risk of psychiatric conditions such as depression and anxiety, is a critical focus of research.</p><p><strong>Methods: </strong>Cis-expression quantitative trait loci (eQTLs) from 31,684 whole blood samples provided by the eQTLGen Consortium, alongside data from a large neuroticism cohort, were analyzed to identify genes causally linked to neuroticism. To further explore the influence of gene expression changes on neuroticism, colocalization analysis was conducted. Identified drug targets were assessed for potential side effects using a phenome-wide association study (PheWAS). Additionally, we utilized multiple databases to explore the interactions between drugs and genes for drug prediction and assess the current medications for drug repurposing.</p><p><strong>Results: </strong>The analysis involved a total of 4473 druggable genes, with two-sample Mendelian randomization (MR) identifying 186 genes that are causally linked to neuroticism. Colocalization analysis highlighted 11 genes (TLR4, MMRN1, EP300, BRAF, ORM1, ACVR1B, LRRC17, NOS2, ADAMTS6, GPX1, and VCL) with a posterior probability of colocalization (PPH4) >0.8. PheWAS revealed that drugs targeting BRAF, LRRC17, ADAMTS6, and GPX1 were also associated with other traits. Notably, six of these genes (TLR4, MMRN1, BRAF, ACVR1B, NOS2, and GPX1) are already being explored for drug development in psychiatric and other diseases.</p><p><strong>Conclusion: </strong>This study pinpointed six genes as promising therapeutic targets for neuroticism. The repurposing and development of drugs targeting these genes hold potential for managing neuroticism and associated psychiatric disorders.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of affective disorders
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