{"title":"探讨甘油三酯水平与家族性高胆固醇血症成人动脉粥样硬化性心血管疾病患病率之间的相关性：来自HELLAS-FH登记的横断面分析的见解","authors":"Panagiotis Anagnostis MD, PhD , Christos V. Rizos MD, PhD , George Liamis MD, PhD , Loukianos Rallidis MD, PhD , Ioannis Skoumas MD, PhD , Genovefa Kolovou MD, PhD , Konstantinos Tziomalos MD, PhD , Emmanouil Skalidis MD, PhD , Anastasia Garoufi MD, PhD , Vasileios Kotsis MD, PhD , Michalis Doumas MD, PhD , George Sfikas MD, PhD , Vaia Lambadiari MD, PhD , Georgia Anastasiou MD, PhD , Ermioni Petkou MD, PhD , Estela Kiouri MD, PhD , Κonstantinos A. Papathanasiou MD, PhD , Ioanna Dima MD, PhD , Vana Kolovou MD, PhD , Evangelos Zacharis MD, PhD , Evangelos Liberopoulos MD, PhD","doi":"10.1016/j.jacl.2024.12.017","DOIUrl":null,"url":null,"abstract":"<div><h3>BACKGROUND</h3><div>High triglyceride (TG) levels are associated with increased atherosclerotic cardiovascular disease (ASCVD) risk in the general population. Yet, the role of TG in familial hypercholesterolemia (FH) remains understudied. This research aims to evaluate the link between TG levels and ASCVD prevalence in adult patients with FH.</div></div><div><h3>METHODS</h3><div>This cross-sectional analysis, derived from the Hellenic Familial Hypercholesterolemia Registry (HELLAS-FH), involves categorizing patients into tertiles based on their TG concentrations.</div></div><div><h3>RESULTS</h3><div>In our study of 1772 adults with heterozygous FH (HeFH), aged 51 ± 15 years at registration and diagnosed at 44 ± 16 years, TG concentrations in the first (80 mg/dL), second (124 mg/dL), and third (200 mg/dL) tertiles revealed varying ASCVD prevalence (18.0%, 28.5%, and 28.5%, respectively). Adjusted for ASCVD risk factors, TGs ≥116 mg/dL were linked to higher ASCVD risk than levels <116 mg/dL (odds ratio: 1.37, 95% CI 1.05-1.80, <em>P</em> = .02).</div></div><div><h3>CONCLUSION</h3><div>A notable association with ASCVD is evident in FH patients, even at relatively low TG levels, starting from 116 mg/dL (1.31 mmol/L).</div></div>","PeriodicalId":15392,"journal":{"name":"Journal of clinical lipidology","volume":"19 3","pages":"Pages 442-450"},"PeriodicalIF":4.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the correlation between triglyceride levels and atherosclerotic cardiovascular disease prevalence in adults with familial hypercholesterolemia: Insights from a cross-sectional analysis in the HELLAS-FH registry\",\"authors\":\"Panagiotis Anagnostis MD, PhD , Christos V. Rizos MD, PhD , George Liamis MD, PhD , Loukianos Rallidis MD, PhD , Ioannis Skoumas MD, PhD , Genovefa Kolovou MD, PhD , Konstantinos Tziomalos MD, PhD , Emmanouil Skalidis MD, PhD , Anastasia Garoufi MD, PhD , Vasileios Kotsis MD, PhD , Michalis Doumas MD, PhD , George Sfikas MD, PhD , Vaia Lambadiari MD, PhD , Georgia Anastasiou MD, PhD , Ermioni Petkou MD, PhD , Estela Kiouri MD, PhD , Κonstantinos A. Papathanasiou MD, PhD , Ioanna Dima MD, PhD , Vana Kolovou MD, PhD , Evangelos Zacharis MD, PhD , Evangelos Liberopoulos MD, PhD\",\"doi\":\"10.1016/j.jacl.2024.12.017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>BACKGROUND</h3><div>High triglyceride (TG) levels are associated with increased atherosclerotic cardiovascular disease (ASCVD) risk in the general population. Yet, the role of TG in familial hypercholesterolemia (FH) remains understudied. This research aims to evaluate the link between TG levels and ASCVD prevalence in adult patients with FH.</div></div><div><h3>METHODS</h3><div>This cross-sectional analysis, derived from the Hellenic Familial Hypercholesterolemia Registry (HELLAS-FH), involves categorizing patients into tertiles based on their TG concentrations.</div></div><div><h3>RESULTS</h3><div>In our study of 1772 adults with heterozygous FH (HeFH), aged 51 ± 15 years at registration and diagnosed at 44 ± 16 years, TG concentrations in the first (80 mg/dL), second (124 mg/dL), and third (200 mg/dL) tertiles revealed varying ASCVD prevalence (18.0%, 28.5%, and 28.5%, respectively). Adjusted for ASCVD risk factors, TGs ≥116 mg/dL were linked to higher ASCVD risk than levels <116 mg/dL (odds ratio: 1.37, 95% CI 1.05-1.80, <em>P</em> = .02).</div></div><div><h3>CONCLUSION</h3><div>A notable association with ASCVD is evident in FH patients, even at relatively low TG levels, starting from 116 mg/dL (1.31 mmol/L).</div></div>\",\"PeriodicalId\":15392,\"journal\":{\"name\":\"Journal of clinical lipidology\",\"volume\":\"19 3\",\"pages\":\"Pages 442-450\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of clinical lipidology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1933287424003027\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/31 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical lipidology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1933287424003027","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/31 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Exploring the correlation between triglyceride levels and atherosclerotic cardiovascular disease prevalence in adults with familial hypercholesterolemia: Insights from a cross-sectional analysis in the HELLAS-FH registry
BACKGROUND
High triglyceride (TG) levels are associated with increased atherosclerotic cardiovascular disease (ASCVD) risk in the general population. Yet, the role of TG in familial hypercholesterolemia (FH) remains understudied. This research aims to evaluate the link between TG levels and ASCVD prevalence in adult patients with FH.
METHODS
This cross-sectional analysis, derived from the Hellenic Familial Hypercholesterolemia Registry (HELLAS-FH), involves categorizing patients into tertiles based on their TG concentrations.
RESULTS
In our study of 1772 adults with heterozygous FH (HeFH), aged 51 ± 15 years at registration and diagnosed at 44 ± 16 years, TG concentrations in the first (80 mg/dL), second (124 mg/dL), and third (200 mg/dL) tertiles revealed varying ASCVD prevalence (18.0%, 28.5%, and 28.5%, respectively). Adjusted for ASCVD risk factors, TGs ≥116 mg/dL were linked to higher ASCVD risk than levels <116 mg/dL (odds ratio: 1.37, 95% CI 1.05-1.80, P = .02).
CONCLUSION
A notable association with ASCVD is evident in FH patients, even at relatively low TG levels, starting from 116 mg/dL (1.31 mmol/L).
期刊介绍：
Because the scope of clinical lipidology is broad, the topics addressed by the Journal are equally diverse. Typical articles explore lipidology as it is practiced in the treatment setting, recent developments in pharmacological research, reports of treatment and trials, case studies, the impact of lifestyle modification, and similar academic material of interest to the practitioner.
Sections of Journal of clinical lipidology will address pioneering studies and the clinicians who conduct them, case studies, ethical standards and conduct, professional guidance such as ATP and NCEP, editorial commentary, letters from readers, National Lipid Association (NLA) news and upcoming event information, as well as abstracts from the NLA annual scientific sessions and the scientific forums held by its chapters, when appropriate.
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