追踪肿瘤相关巨噬细胞

IF 3.9 3区 农林科学 Q1 VETERINARY SCIENCES Lab Animal Pub Date : 2025-02-03 DOI:10.1038/s41684-025-01511-w
Alexandra Le Bras
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引用次数: 0

摘要

肿瘤相关巨噬细胞(tam)是肿瘤微环境的重要组成部分,主要被认为具有促肿瘤作用。因此,开发靶向tam的成像示踪剂对肿瘤监测和疗效评估具有重要意义。PNAS上的一项新研究报道了一种基于纳米体的免疫示踪剂的开发,该免疫示踪剂靶向CD163-a受体,主要在巨噬细胞上表达,以非侵入性地监测体内巨噬细胞。在制备和标记抗cd163免疫示踪剂后,研究人员将示踪剂注射到naïve和荷瘤小鼠体内,并进行微单光子发射计算机断层扫描/计算机断层扫描(μSPECT/CT)和微正电子发射断层扫描(μPET)/CT成像,证实了其对小鼠巨噬细胞和tam的特异性靶向作用。重要的是,在接受免疫治疗的荷瘤小鼠中,示踪剂能够将TAM定位与治疗反应性联系起来。这种示踪剂可能成为监测tam和跟踪癌症患者免疫治疗反应的有用工具。原文献:Lauwers, Y.等。Proc。国家的。学会科学。USA 121, e2409668121 (2024)
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Tracking tumor-associated macrophages
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来源期刊
Lab Animal
Lab Animal 农林科学-兽医学
CiteScore
0.60
自引率
2.90%
发文量
181
审稿时长
>36 weeks
期刊介绍: LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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