母亲压力的传递

IF 3.9 3区 农林科学 Q1 VETERINARY SCIENCES Lab Animal Pub Date : 2025-02-03 DOI:10.1038/s41684-025-01514-7
Alexandra Le Bras
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引用次数: 0

摘要

产前母亲压力(PNMS)与不良妊娠结局相关,并预测后代较差的发育和健康结局。先前的研究表明,暴露于PNMS可以通过诱导表观遗传修饰(如DNA甲基化(DNAm))和短非编码rna(如microRNAs (miRNAs))的表达来影响F1的产生。如果PNMS发生在原始生殖细胞发育过程中,这些表观遗传修饰可以影响生殖系并在几代之间传播,但这些分子变化的影响尚不完全清楚。一项使用PNMS大鼠模型的新研究表明,PNMS可以影响四代(F0-F3)胎盘功能和胎儿大脑发育。研究人员在胚胎期E12-E18(跨代表观遗传编程的关键窗口期)给怀孕大鼠注射了PNMS,并分析了4代间DNAm、miRNA和mRNA的表达。他们的研究结果显示,F2和F3代的累积变化比F1代显著增加,表明PNMS的后果在几代之间积累。原始参考文献:King, S.E.等人。Commun。生物学报,8,38 (2025)
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来源期刊
Lab Animal
Lab Animal 农林科学-兽医学
CiteScore
0.60
自引率
2.90%
发文量
181
审稿时长
>36 weeks
期刊介绍: LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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