达托霉素在甲氧西林敏感金黄色葡萄球菌血流感染门诊患者中的应用评价。

IF 3.8 4区医学 Q2 IMMUNOLOGY Open Forum Infectious Diseases Pub Date : 2025-01-17 eCollection Date: 2025-02-01 DOI:10.1093/ofid/ofaf012

Daisy Kener, Darrell Childress, Ian Andrus, Jared Olson, Brandon Webb

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引用次数: 0

摘要

对耐甲氧西林金黄色葡萄球菌和肠球菌感染的多项观察性研究表明，更高剂量的达托霉素可能与更好的临床结果相关。然而，甲氧西林敏感金黄色葡萄球菌血流感染的最佳达托霉素剂量仍不清楚。在这项多中心、回顾性、观察性队列研究中，我们比较了标准剂量达托霉素（金黄色葡萄球菌）血流感染。在倾向加权模型中，与标准剂量组相比，高剂量组90天内治疗失败的综合结局较低(优势比0.496；95% ci, 0.306 - 0.804)。我们没有发现安全结果有任何显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Evaluation of Daptomycin Use in Outpatients With Methicillin-Sensitive Staphylococcus aureus Bloodstream Infections.

Multiple observational studies in methicillin-resistant Staphylococcus aureus and enterococcal infections have suggested that higher doses of daptomycin may be associated with better clinical outcomes. However, optimal daptomycin dosing in methicillin-sensitive S aureus bloodstream infections remains unclear. In this multicentered, retrospective, observational cohort study, we compared standard dose daptomycin (<8 mg/kg) vs high dose (≥8 mg/kg) for methicillin-sensitive S aureus bloodstream infections. In a propensity-weighted model, the composite outcome of treatment failure within 90 days was lower in the high-dose group relative to the standard dose group (odds ratio, 0.496; 95% CI, .306-.804). We did not detect any significant difference in safety outcomes.

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.