Qijun Sun, Jie Yu, Renguo Zhang, Xueling Yu, Jiating Xu, Na Niu* and Ligang Chen*,
{"title":"Fe、Co-MOF纳米酶表达过氧化物酶样活性的集成调控：增强对H2O2的亲和力和异烟肼的分析","authors":"Qijun Sun, Jie Yu, Renguo Zhang, Xueling Yu, Jiating Xu, Na Niu* and Ligang Chen*, ","doi":"10.1021/acsmaterialslett.4c02563","DOIUrl":null,"url":null,"abstract":"<p >The limited affinity of horseradish peroxidase (HRP) for H<sub>2</sub>O<sub>2</sub> makes it unsuitable for identifying situations containing trace amounts of H<sub>2</sub>O<sub>2</sub>. Herein, a set of regulation schemes for Fe, Co-MOF was proposed to develop a substitute for HRP. Regarding H<sub>2</sub>O<sub>2</sub> adsorption, solvent engineering allowed the MIL framework to expose the (101) crystal plane with the highest density of Lewis acid sites, and the unsaturated center of the ligand generated by the Co sites on the 1D metal–oxygen chain facilitates the adsorption of H<sub>2</sub>O<sub>2</sub> in sub-nanochannels. Regarding H<sub>2</sub>O<sub>2</sub> reduction, ligand amination engineering created electron donor regions. Hydrogenation engineering increased the number of Fe<sup>2+</sup> as catalytic centers, and the synergy between <i>in situ</i> modified tiny AuNPs and them reduced the activation energy of the peroxidase-like reaction. Ultimately, the affinity of Fe, Co-MOF for H<sub>2</sub>O<sub>2</sub> was increased by 70 times compared with HRP. As a proof-of-concept, it was used to detect isoniazid, a typical antituberculosis drug, in human urine samples.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"7 2","pages":"646–653 646–653"},"PeriodicalIF":8.7000,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Integrated Modulation of Fe, Co-MOF Nanozymes for Expressing Peroxidase-like Activity: Enhanced Affinity for H2O2 and Analysis of Isoniazid\",\"authors\":\"Qijun Sun, Jie Yu, Renguo Zhang, Xueling Yu, Jiating Xu, Na Niu* and Ligang Chen*, \",\"doi\":\"10.1021/acsmaterialslett.4c02563\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >The limited affinity of horseradish peroxidase (HRP) for H<sub>2</sub>O<sub>2</sub> makes it unsuitable for identifying situations containing trace amounts of H<sub>2</sub>O<sub>2</sub>. Herein, a set of regulation schemes for Fe, Co-MOF was proposed to develop a substitute for HRP. Regarding H<sub>2</sub>O<sub>2</sub> adsorption, solvent engineering allowed the MIL framework to expose the (101) crystal plane with the highest density of Lewis acid sites, and the unsaturated center of the ligand generated by the Co sites on the 1D metal–oxygen chain facilitates the adsorption of H<sub>2</sub>O<sub>2</sub> in sub-nanochannels. Regarding H<sub>2</sub>O<sub>2</sub> reduction, ligand amination engineering created electron donor regions. Hydrogenation engineering increased the number of Fe<sup>2+</sup> as catalytic centers, and the synergy between <i>in situ</i> modified tiny AuNPs and them reduced the activation energy of the peroxidase-like reaction. Ultimately, the affinity of Fe, Co-MOF for H<sub>2</sub>O<sub>2</sub> was increased by 70 times compared with HRP. As a proof-of-concept, it was used to detect isoniazid, a typical antituberculosis drug, in human urine samples.</p>\",\"PeriodicalId\":19,\"journal\":{\"name\":\"ACS Materials Letters\",\"volume\":\"7 2\",\"pages\":\"646–653 646–653\"},\"PeriodicalIF\":8.7000,\"publicationDate\":\"2025-01-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Materials Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsmaterialslett.4c02563\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Materials Letters","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsmaterialslett.4c02563","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Integrated Modulation of Fe, Co-MOF Nanozymes for Expressing Peroxidase-like Activity: Enhanced Affinity for H2O2 and Analysis of Isoniazid
The limited affinity of horseradish peroxidase (HRP) for H2O2 makes it unsuitable for identifying situations containing trace amounts of H2O2. Herein, a set of regulation schemes for Fe, Co-MOF was proposed to develop a substitute for HRP. Regarding H2O2 adsorption, solvent engineering allowed the MIL framework to expose the (101) crystal plane with the highest density of Lewis acid sites, and the unsaturated center of the ligand generated by the Co sites on the 1D metal–oxygen chain facilitates the adsorption of H2O2 in sub-nanochannels. Regarding H2O2 reduction, ligand amination engineering created electron donor regions. Hydrogenation engineering increased the number of Fe2+ as catalytic centers, and the synergy between in situ modified tiny AuNPs and them reduced the activation energy of the peroxidase-like reaction. Ultimately, the affinity of Fe, Co-MOF for H2O2 was increased by 70 times compared with HRP. As a proof-of-concept, it was used to detect isoniazid, a typical antituberculosis drug, in human urine samples.
期刊介绍：
ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.
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