纳米催化剂合成β-氨基羰基化合物的研究进展

Tetrahedron Green Chem Pub Date : 2025-06-01 Epub Date: 2025-01-25 DOI:10.1016/j.tgchem.2025.100065
Satyaranjan Behera
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引用次数: 0

摘要

纳米材料由于其非凡的优势,包括大的表面积,引起了研究人员在各个领域的兴趣。纳米材料在催化中的应用一直是研究人员关注的热点。催化在药物和药物化合物的合成中起着至关重要的作用。医药化学品,包括β-氨基羰基化合物及其衍生物,通常用作制造天然产物、药品、生理活性分子和药物的合成中间体。β-氨基羰基化合物的合成涉及许多过程,包括Mannich反应和aza-Michael反应。由于其严重的副作用,合成β-氨基羰基化合物对化学家来说仍然具有挑战性。研究人员现在已经使用纳米催化剂来实现干净和平滑的反应,高纯度的产品,和可重复使用。纳米催化剂由于具有较高的比表面积,具有很强的催化活性。目前,人们开发了许多改性纳米催化剂,以获得高收率的产品。综述了目前报道的利用不同纳米催化剂合成β-氨基羰基化合物的研究进展。
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A review on synthesis of β-amino carbonyl compounds using nanocatalyst
Nanomaterials have piqued researchers' interest in various fields due to their extraordinary advantages, which include a large surface area. The use of nanomaterials in catalysis is a hot issue for researchers. Catalysis plays a vital role in the synthesis of medicinal as well as pharmaceutical compounds. Pharmaceutical chemicals, including β-amino carbonyl compounds and their derivatives, are commonly used as synthetic intermediates in manufacturing natural products, pharmaceuticals, physiologically active molecules, and medicines. Synthesis of β-amino carbonyl compounds involves many processes, including Mannich and aza-Michael reactions. The synthesis of β-amino carbonyl compounds remains challenging for chemists due to their severe side products. Researchers have now used nanocatalysts to achieve clean and smooth reactions, high purity of products, and reusability. Due to high surface area, nanocatalysts have tremendous catalytic activity. Nowadays many modified nanocatalyst have been developed to produce high yields of the products. The present review described the synthesis of β-amino carbonyl compounds by using different nanocatalysts reported to date.
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