封面专题：拓展“萜烯”：非特异性过氧酶（UPOs）在非天然萜类化合物氧化中的应用（ChemCatChem 1/2025）

IF 4.1 3区化学 Q2 CHEMISTRY, PHYSICAL ChemCatChem Pub Date : 2025-01-09 DOI:10.1002/cctc.202580102

Henry Struwe, Dr. Christopher Grimm, Dr. Gerald Dräger, Prof. Sascha Beutel, Prof. Miguel Alcalde, Prof. Andreas Kirschning, Prof. Selin Kara

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引用次数: 0

摘要

Cover Feature展示了通过化学和酶催化相结合，在萜类化合物的后期氧化中探索创新路线，首次成功实现了复杂的三环和大环萜类化合物的氧化功能化。通过非特异性过氧酶（UPOs）催化的环氧化和羟基化反应，形成了新的氧烷和半缩醛，扩大了萜烯，并解锁了香料、香料和原料药等生物活性化合物的途径。更多信息可以在A. Kirschning， S. Kara和同事的研究文章中找到（DOI: 10.1002/cctc.202401414）。汉娜·格林博士的封面设计得到了认可。

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Cover Feature: Expanding the “Terpenome”: Applications of Unspecific Peroxygenases (UPOs) in Oxidations of Unnatural Terpenoids (ChemCatChem 1/2025)

The Cover Feature shows the exploration of innovative routes in the late-stage oxidation of terpenoids by combining chemical and enzymatic catalysis to achieve the first successful oxyfunctionalization of complex tricyclic and macrocyclic terpenoids. Novel oxiranes and hemiacetals were formed through epoxidation and hydroxylation catalyzed by unspecific peroxygenases (UPOs), expanding the terpenome and unlocking pathways for bioactive compounds like flavors, fragrances, and APIs. More information can be found in the Research Article by A. Kirschning, S. Kara and co-workers (DOI: 10.1002/cctc.202401414). Dr. Hanna Grimm is acknowledged for the cover design.

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来源期刊

ChemCatChem 化学-物理化学

CiteScore

8.10

自引率

4.40%

发文量

511

审稿时长

1.3 months

期刊介绍： With an impact factor of 4.495 (2018), ChemCatChem is one of the premier journals in the field of catalysis. The journal provides primary research papers and critical secondary information on heterogeneous, homogeneous and bio- and nanocatalysis. The journal is well placed to strengthen cross-communication within between these communities. Its authors and readers come from academia, the chemical industry, and government laboratories across the world. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and is supported by the German Catalysis Society.