Ryoya Wakabayashi, Taiga Ohnishi, Dr. Raku Irie, Dr. Masato Oikawa
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A One-Pot Conversion of N-Ns to N-Boc Group in Polyamine Synthesis
We report herein an efficient synthesis of fully Boc-protected, up to 13-meric polymer of 1,3-propanediamine. The synthesis was facilitated by one-pot conversion of (up to six) N-Ns groups to N-Boc groups under conditions of 1) PhSH and Cs2CO3 for deprotection of the Ns group, followed by 2) Boc2O for Boc protection. The average yield per Ns group was extremely high, especially for substrates with four to six Ns groups (94.6%–96.6%).
期刊介绍：
ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.
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