IF 2.2 4区 医学 Q2 BIOLOGY Chronobiology International Pub Date : 2025-02-03 DOI:10.1080/07420528.2025.2460643
Joon Sung Shin, Sanghyup Jung, Geun Hui Won, Sun Hyung Lee, Jaehyun Kim, Saim Jung, Chan-Woo Yeom, Kwang-Min Lee, Kyung-Lak Son, Jang-Il Kim, Sook Young Jeon, Han-Byoel Lee, David Spiegel, Bong-Jin Hahm
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引用次数: 0

摘要

化疗引起的周围神经病变(CIPN)是化疗的一种常见不良反应。这项前瞻性观察研究旨在探讨昼夜节律失调(CM)(通过生物和行为节律的相位角差(PAD)测量)与 CIPN 之间的关系。研究人员测量了乳腺癌患者皮质醇尖相相位差和基于动觉计的睡眠结束时间的相位角差,并根据中位值将其分为低相位角差组(11 人)和高相位角差组(12 人)。使用欧洲癌症研究和治疗组织生活质量问卷-CIPN20(CIPN20)对CIPN进行评估。CM评估显示,与皮质醇前相位相比,低PAD组的睡眠结束时间更晚。与高 PAD 组相比,低 PAD 组在化疗后一个月的 CIPN20 整体和感觉量表评分明显更高,估计组间差异为(17.63 ± 4.75)和(27.07 ± 6.70)(P = 0.001 和 P = 0.002)。
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The association between the circadian misalignment of serum cortisol acrophase and sleep end time with chemotherapy-induced peripheral neuropathy.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of chemotherapy. The objective of this prospective observational study was to examine the association between circadian misalignment (CM), as measured by phase angle difference (PAD) of biological and behavioral rhythms and CIPN. The PAD of cortisol acrophase and actigraphy-based sleep end time in breast cancer patients was measured and categorized into low PAD (n = 11) and high PAD (n = 12) groups based on median value. CIPN was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-CIPN20 (CIPN20). The assessment of CM revealed that the sleep end time of the low PAD group was more delayed in relation to cortisol acrophase compared to the high PAD group. The low PAD group demonstrated significantly higher CIPN20 global and sensory scale scores compared to the high-PAD group at one month post-chemotherapy, with an estimated group difference of 17.63 ± 4.75 and 27.07 ± 6.70 (p = 0.001 and p < 0.001, respectively). The present findings indicate that the low PAD group, which exhibited a relatively delayed behavioral rhythm with respect to its biological rhythm, displayed an increased susceptibility to CIPN. Further large-sample research is necessary to attain a comprehensive understanding of the mechanisms through which CM affects CIPN.

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来源期刊
Chronobiology International
Chronobiology International 生物-生理学
CiteScore
5.60
自引率
7.10%
发文量
110
审稿时长
1 months
期刊介绍: Chronobiology International is the journal of biological and medical rhythm research. It is a transdisciplinary journal focusing on biological rhythm phenomena of all life forms. The journal publishes groundbreaking articles plus authoritative review papers, short communications of work in progress, case studies, and letters to the editor, for example, on genetic and molecular mechanisms of insect, animal and human biological timekeeping, including melatonin and pineal gland rhythms. It also publishes applied topics, for example, shiftwork, chronotypes, and associated personality traits; chronobiology and chronotherapy of sleep, cardiovascular, pulmonary, psychiatric, and other medical conditions. Articles in the journal pertain to basic and applied chronobiology, and to methods, statistics, and instrumentation for biological rhythm study. Read More: http://informahealthcare.com/page/cbi/Description
期刊最新文献
Effects of caffeinated coffee on physical and cognitive performance: Chronotype and time of day study. The association between the circadian misalignment of serum cortisol acrophase and sleep end time with chemotherapy-induced peripheral neuropathy. Bibliometric analysis of global research status and trends of circadian rhythms in cancer from 2004 to 2024. Self-reported preferences for seasonal daylight saving time meet fundamentals of human physiology: Correlations in the 2018 public consultation by the European Commission. General procrastination associated with the evening preference in healthy people but not with circadian rhythm sleep-wake disorders with phase delay.
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