Chronobiology International最新文献

This study examined the effects of caffeinated coffee (3 mg/kg) compared to decaffeinated coffee (placebo) on physical and cognitive performance in trained male athletes with morning (MT) and evening (ET) chronotypes, all of whom had moderate caffeine intake. Seventeen trained male athletes participated in various tests, including CP (a flanker task), hand grip strength test, back strength test, lower body Wingate sprint tests (peak and average power), and rating of perceived exertion (using the Borg Scale). The tests were conducted at two times of day: mornings (08:00 h-10:00 h) and evenings (16:00 h-18:00 h). Results indicated that caffeinated coffee significantly enhanced handgrip strength [F(1, 15) = 11.200, p = 0.001, η²p = .427], back strength [F(1, 15) = 8.695, p = 0.001, η²p = 0.367], and lower body Wingate test performance, including peak strength [F(1, 15) = 8.384, p = 0.001, η²p = 0.359] and mean strength [F(1, 15) = 8.304, p = 0.001, η²p = 0.356], regardless of chronotype. Conversely, no significant differences were observed in the cognitive performance (CP) measured by the flanker task and in Borg's perceived exertion ratings. When analyzing the interaction between groups × CAF & PLA, significant differences were found in the handgrip strength test [F(3, 45) = 17.443, p = 0.001, η²p = 0.538], back strength test [F(3, 45) = 19.926, p = 0.001, η²p = 0.571], peak power [F(3, 45) = 12.285, p = 0.001, η²p = 0.450], and average power [F(3, 45) = 6.633, p = 0.009, η²p = 0.307]. However, no significant differences were noted in cognitive performance (CP) and Borg perceived exertion ratings. These findings suggest that chronotype, timing of training, and caffeine consumption can significantly influence physical performance in trained men with moderate caffeine intake.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of chemotherapy. The objective of this prospective observational study was to examine the association between circadian misalignment (CM), as measured by phase angle difference (PAD) of biological and behavioral rhythms and CIPN. The PAD of cortisol acrophase and actigraphy-based sleep end time in breast cancer patients was measured and categorized into low PAD (n = 11) and high PAD (n = 12) groups based on median value. CIPN was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-CIPN20 (CIPN20). The assessment of CM revealed that the sleep end time of the low PAD group was more delayed in relation to cortisol acrophase compared to the high PAD group. The low PAD group demonstrated significantly higher CIPN20 global and sensory scale scores compared to the high-PAD group at one month post-chemotherapy, with an estimated group difference of 17.63 ± 4.75 and 27.07 ± 6.70 (p = 0.001 and p < 0.001, respectively). The present findings indicate that the low PAD group, which exhibited a relatively delayed behavioral rhythm with respect to its biological rhythm, displayed an increased susceptibility to CIPN. Further large-sample research is necessary to attain a comprehensive understanding of the mechanisms through which CM affects CIPN.

Research linking circadian dysregulation to cancer development has received increasing attention recently. However, a comprehensive understanding of research hotspots and trends in this area remains limited. International studies on the circadian rhythms in cancer were retrieved and downloaded from the Web of Science database. Bibliometric analysis and visualization were performed using VOSviewer, CiteSpace, and HistCite. Three thousand three hundred and eighteen English articles from 2004 to 2024 were screened and evaluated. The increase in publications and citations reflected the rapid expansion of the field. Scholars and institutions in the United States have relatively high academic productivity and impact. Chronobiology International is the most popular journal. Key clustering analysis identified six themes: biochemistry and molecular biology, physiology and immunomodulation, night shift work and health effects, physiological and mental health, tumor therapy research, and oxidative stress and cancer-related mechanisms. Keyword burst analysis identified the regulation of circadian rhythms on cells and tumor microenvironment as the research frontiers. The role of circadian rhythms in tumor immunotherapy was a current research hotspot identified by reference co-citation clustering analysis. This study reveals the current status of research on the circadian rhythms in cancer and predicts future trends. These findings provide new ideas for developing novel cancer prevention and treatment strategies.

We analyze the results to question 2 (individual preferences for cancelling or keeping the current clock regulations) from the 2018 Public Consultation on summertime arrangements (DST) conducted by the European Commission. We reveal correlations in the shares of population for cancelling the regulations and the winter sunrise time (SRW) [R² = 0.177; p = 0.03; N = 25] and the onset of human activity [R² = 0.677; p = 5 × 10^-5; N = 17]. The results are in line with the rationale behind the regulations in the range of latitude 35 to 63: larger values of SRW (larger latitude) brought larger shares against the regulations; and earlier onset of human activity relative to SRW brought larger shares against the regulations. The shares for cancelling the regulation did not show correlations with time offset (position in time zone), thus challenging the current view within the circadian community.

Procrastination behavior has been reportedly associated with the evening preference. This study aimed to evaluate its difference between patients with circadian rhythm sleep-wake disorders with phase delay (CRSWDswPD) and healthy controls in terms of evening preference and comorbid psychiatric disorders. Thirty patients with CRSWDswPD and 29 healthy participants were included. In both groups, the general procrastination scale (GPS), Beck Depression Inventory (BDI), and Morningness-Eveningness Questionnaire (MEQ) were administered. Additionally, Adult ADHD Self-Report Scale (ASRS) and autism spectrum quotient (AQ) were also assessed in the patient group. Unexpectedly, GPS was not statistically different between patients with CRSWDswPD and healthy controls. GPS was significantly higher with lower MEQ in the healthy group, whereas the opposite tendency was observed in the patient group. Higher AQ, ASRS, and BDI tended to be associated with higher GPS in the patient group, with the first two being statistically significant. The results suggest that general procrastination is not significantly associated with CRSWDswPD, although it is associated with evening preference in healthy participants. Procrastination in the patient group may be associated with developmental disorders or depression tendencies. Future studies should include simultaneous measurement of circadian markers, other behavioral assessments, a larger population, and untreated patients.

The intricate relationship between circadian rhythms and mood is well-established. Disturbances in circadian rhythms and sleep often precede the development of mood disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and seasonal affective disorder (SAD). Two primary factors, intrinsic circadian clocks and light, drive the natural fluctuations in mood throughout the day, mirroring the patterns of sleepiness and wakefulness. Nearly all organisms possess intrinsic circadian clocks that coordinate daily rhythms, with light serving as the primary environmental cue to synchronize these internal timekeepers with the 24-hour cycle. Additionally, light directly influences mood states. Disruptions to circadian rhythms, such as those caused by jet lag, shift work, or reduced daylight hours, can trigger or exacerbate mood symptoms. The complex and often subtle connections between circadian disruptions and mood dysregulation suggest that focusing solely on individual clock genes is insufficient to fully understand their etiology and progression. Instead, mood instability may arise from systemic misalignments between external cycles and the internal synchronization of circadian clocks. Here, we synthesize past research on the independent contributions of circadian clocks and light to mood regulation, drawing particularly on insights from animal studies that illuminate fundamental mechanisms relevant to human health.

Mental health problems are more prevalent in evening-oriented individuals than in their morning-oriented counterparts. Recently, research has offered first insights into how the negative effects of eveningness on mental health and well-being can be magnified or alleviated depending on accompanying psychological characteristics. In the current study, we evaluated how eveningness relates to mattering and anti-mattering and whether mattering and anti-mattering can moderate the association between eveningness and mental health. The participants were 692 Polish adults (337 women, 355 men) aged between 21 and 57 years (M ± SD: 39.76 ± 9.63). All participants completed measures of morningness-eveningness and depressive and anxiety symptoms, the General Mattering Scale (GMS) and the Anti-Mattering Scale (AMS). Conducted analyses showed that 1) the Polish versions of GMS and AMS have appropriate reliability and validity, 2) eveningness is negatively associated with mattering and positively associated with anti-mattering, depressive, and anxiety symptoms, and 3) the magnitude of the association between eveningness and mental health symptoms increased with higher anti-mattering and lower mattering. Overall, this study presents the first evidence of how feelings of being important and being valued may buffer against the negative effects of eveningness on mental health.

Lithium has long been used as a cornerstone mood stabilizer in the treatment of bipolar disorder (BD). However, reliable biomarkers that can predict which patients will respond better to lithium are still lacking. This study aims to evaluate the potential of NR1D1 gene SNP; rs2071427 and actigraphic measurements in predicting lithium response. Thirty-one patients diagnosed with BD at Selçuk University Faculty of Medicine and who were euthymic for at least 8 weeks were included in the study. Sleep-wake cycles and circadian rhythms of the participants were monitored by actigraph for approximately 1 week. For genetic analyses, the SNP rs2071427 variant of the NR1D1 gene was evaluated. A significant proportion of patients with homozygous (AA/GG) genotypes responded well to lithium, whereas some patients with heterozygous (AG) genotypes did not respond to lithium. Actigraphic data showed that there were marked variations in the sleep patterns of BD patients. The Morningness-Eveningness Questionnaire scale did not adequately discriminate the morning chronotype. Seasonal Pattern Assessment Questionnaire results showed that most patients had a seasonal pattern, but this was insufficient to predict response to lithium. This study once again demonstrates the need for new biomarkers to predict lithium response. The findings are an important step in the personalization of BD treatment and may improve treatment efficacy and minimize side effects by tailoring the treatment process to the individual characteristics of patients. Future studies should support these findings with larger sample groups and studies on different genetic markers.

Epidemiological studies show a high prevalence of "insomnia" in adolescents. However, insomnia symptoms are not specific for insomnia disorder. Puberty is associated with circadian delay, which may cause insomnia symptoms such as problems falling asleep and daytime impairments, but also difficulties rising in the morning which is not a hallmark of insomnia disorder. The aim of this study was to investigate the extent to which adolescent insomnia symptoms may be attributed to circadian delay. The sample comprised 3,867 high-school-students. Survey instruments included the Bergen Insomnia Scale (BIS), the Munich ChronoType Questionnaire (MCTQ), the reduced Morningness-Eveningness Questionnaire (r-MEQ), and items on subjective sleep problems and sleep-related behaviors. Symptoms of circadian delay (CD) were defined as i) trouble waking on school days, ii) ability to sleep long into the day, iii) waking ≥10:00 on free days and/or iv) oversleeping for school. A total of 34.5% reported insomnia according to BIS. Among these, 88.4% reported ≥1 CD-symptom and 15.5% reported all CD-symptoms. Adolescents with insomnia and ≥1 CD-symptom were often evening-types (56.9%), had long social jetlag (2:55 h) and large school-/free day discrepancy in sleep duration (6:04 vs. 8:34 h). Results suggest circadian delay as a plausible explanation for insomnia symptoms in many adolescents.