Jinting Shang , Lufang Su , Liping Li , Xin Yu , Yan Yang , Chen Wang , Jingran Wang , Xuannan Zhang , Yuran Gui , Wei Liu , Yiyuan Xia , Xiji Shu , Yibin Zhang
{"title":"一种新型的基于杂蒽的近红外荧光探针，用于高灵敏度检测小鼠眼球血液中的UO₂2 +","authors":"Jinting Shang , Lufang Su , Liping Li , Xin Yu , Yan Yang , Chen Wang , Jingran Wang , Xuannan Zhang , Yuran Gui , Wei Liu , Yiyuan Xia , Xiji Shu , Yibin Zhang","doi":"10.1016/j.dyepig.2024.112618","DOIUrl":null,"url":null,"abstract":"<div><div>The radiotoxicity and chemical toxicity of UO₂<sup>2</sup>⁺ pose a long-term threat to ecosystems and human health through bioaccumulation and biomagnification. Therefore, there is an urgent need to develop highly sensitive and selective detection methods for UO₂<sup>2</sup>⁺. Here, we developed a near-infrared (NIR) fluorescent probe <strong>RU</strong>, built on a xanthene core structure. Upon binding with UO₂<sup>2</sup>⁺, <strong>RU</strong> undergoes ring-opening, triggering fluorescence turn on. <strong>RU</strong> exhibited high selectivity, sensitivity, and rapid response toward UO₂<sup>2</sup>⁺. Besides, we have successfully employed <strong>RU</strong> to visualize UO₂<sup>2</sup>⁺ in the blood of mice's eyeballs for the first time, providing a valuable method to investigate its biological behavior and toxicity in living system.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"235 ","pages":"Article 112618"},"PeriodicalIF":4.2000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A novel xanthene-based NIR fluorescent probe for the high-sensitivity detection of UO₂2⁺ in the blood from mice eyeballs\",\"authors\":\"Jinting Shang , Lufang Su , Liping Li , Xin Yu , Yan Yang , Chen Wang , Jingran Wang , Xuannan Zhang , Yuran Gui , Wei Liu , Yiyuan Xia , Xiji Shu , Yibin Zhang\",\"doi\":\"10.1016/j.dyepig.2024.112618\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The radiotoxicity and chemical toxicity of UO₂<sup>2</sup>⁺ pose a long-term threat to ecosystems and human health through bioaccumulation and biomagnification. Therefore, there is an urgent need to develop highly sensitive and selective detection methods for UO₂<sup>2</sup>⁺. Here, we developed a near-infrared (NIR) fluorescent probe <strong>RU</strong>, built on a xanthene core structure. Upon binding with UO₂<sup>2</sup>⁺, <strong>RU</strong> undergoes ring-opening, triggering fluorescence turn on. <strong>RU</strong> exhibited high selectivity, sensitivity, and rapid response toward UO₂<sup>2</sup>⁺. Besides, we have successfully employed <strong>RU</strong> to visualize UO₂<sup>2</sup>⁺ in the blood of mice's eyeballs for the first time, providing a valuable method to investigate its biological behavior and toxicity in living system.</div></div>\",\"PeriodicalId\":302,\"journal\":{\"name\":\"Dyes and Pigments\",\"volume\":\"235 \",\"pages\":\"Article 112618\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dyes and Pigments\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0143720824006855\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dyes and Pigments","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0143720824006855","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
A novel xanthene-based NIR fluorescent probe for the high-sensitivity detection of UO₂2⁺ in the blood from mice eyeballs
The radiotoxicity and chemical toxicity of UO₂2⁺ pose a long-term threat to ecosystems and human health through bioaccumulation and biomagnification. Therefore, there is an urgent need to develop highly sensitive and selective detection methods for UO₂2⁺. Here, we developed a near-infrared (NIR) fluorescent probe RU, built on a xanthene core structure. Upon binding with UO₂2⁺, RU undergoes ring-opening, triggering fluorescence turn on. RU exhibited high selectivity, sensitivity, and rapid response toward UO₂2⁺. Besides, we have successfully employed RU to visualize UO₂2⁺ in the blood of mice's eyeballs for the first time, providing a valuable method to investigate its biological behavior and toxicity in living system.
期刊介绍：
Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied.
Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media.
The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.
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