{"title":"药物性肝损伤及改进诊断方法的迫切需要","authors":"Yoshiyasu Takefuji","doi":"10.1016/j.hmedic.2025.100170","DOIUrl":null,"url":null,"abstract":"<div><div>A review conducted by the National Library of Medicine has associated antibiotics, antidepressants, and other medications with liver damage. Researchers examined thousands of cases, investigating risk factors, diagnostic challenges, and the role of gut bacteria. They particularly focused on specific medications, including doxycycline and cyclophosphamide. There is an urgent need for the development of more accurate diagnostic tests for human Drug-Induced Liver Injury (DILI). The new findings underscore the necessity for improved diagnostic tools, such as biomarkers, to identify drug-induced liver injury effectively.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"9 ","pages":"Article 100170"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Drug-induced liver injury and the urgent need for improved diagnostic test\",\"authors\":\"Yoshiyasu Takefuji\",\"doi\":\"10.1016/j.hmedic.2025.100170\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A review conducted by the National Library of Medicine has associated antibiotics, antidepressants, and other medications with liver damage. Researchers examined thousands of cases, investigating risk factors, diagnostic challenges, and the role of gut bacteria. They particularly focused on specific medications, including doxycycline and cyclophosphamide. There is an urgent need for the development of more accurate diagnostic tests for human Drug-Induced Liver Injury (DILI). The new findings underscore the necessity for improved diagnostic tools, such as biomarkers, to identify drug-induced liver injury effectively.</div></div>\",\"PeriodicalId\":100908,\"journal\":{\"name\":\"Medical Reports\",\"volume\":\"9 \",\"pages\":\"Article 100170\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2949918625000154\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949918625000154","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/28 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Drug-induced liver injury and the urgent need for improved diagnostic test
A review conducted by the National Library of Medicine has associated antibiotics, antidepressants, and other medications with liver damage. Researchers examined thousands of cases, investigating risk factors, diagnostic challenges, and the role of gut bacteria. They particularly focused on specific medications, including doxycycline and cyclophosphamide. There is an urgent need for the development of more accurate diagnostic tests for human Drug-Induced Liver Injury (DILI). The new findings underscore the necessity for improved diagnostic tools, such as biomarkers, to identify drug-induced liver injury effectively.