微流控芯片内非对称排列Tesla微混合器的设计与优化

IF 3.9 3区 工程技术 Q3 ENERGY & FUELS Chemical Engineering and Processing - Process Intensification Pub Date : 2025-03-01 Epub Date: 2025-01-19 DOI:10.1016/j.cep.2025.110181
Jiangtao Li , Baojian Ma , Xiangyu Zhang , Qunxi Zhao , Runze Sun , Jiachen Zhao
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引用次数: 0

摘要

微混合器作为微全分析系统中至关重要的预处理部分,广泛应用于生物工程、生化分析、化学检测等领域。本研究设计了一种新型的非对称Tesla微混合器(TSM)。非对称排列的特斯拉单元产生了显著的涡流和局部混合效果,提高了整体混合效率。研究了障碍物布置、几何形状和尺寸对微混合器混合性能的影响。结果表明,不同浓度的流体沿TSM流体界面不断被压缩碰撞,提高了混合过程中的横向扩散效果。雷诺数Re在30 ~ 100之间时,TSM的混合效率超过0.7。与其他非对称排列的特斯拉微混频器相比,TSM结构更简单,混合过程中的压降更小。双向障碍物布置比单向障碍物布置在诱导二次涡和增强流体混合方面更有效,三角形障碍物在促进流体混合方面优于菱形和圆柱形障碍物。TSM为双向布局,呈三角形,障碍物尺寸D=150µm,在Re为20 ~ 100的范围内,混合指数在0.85 ~ 0.99之间。该研究为特斯拉微混合器的设计和优化提供了有价值的见解,为微流体系统中的流体混合提供了重要的指导。
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Design and optimization of Tesla micromixer with asymmetrical arrangement for efficient mixing in microfluidic chip
As a crucial pre-treatment part of the Micro Total Analysis Systems, micromixers are widely used in bioengineering, biochemical analysis, chemical detection and other fields. In this study, a novel Tesla micromixer (TSM) with an asymmetrical arrangement is designed. The asymmetrically arranged Tesla units generate significant vortices and localized mixing effects, enhancing the overall mixing efficiency. The effects of obstacle arrangement, geometry, and size on its mixing performance of the micromixer are investigated. The results indicate that fluids of varying concentrations are continuously compressed and collided along the TSM's fluid interface, improving the transverse diffusion effect during the mixing process. At Reynolds numbers (Re) between 30 and 100, the TSM achieves a mixing efficiency exceeding 0.7. Compared to other asymmetrically arranged Tesla micromixers, the TSM features a simpler structure and experiences less pressure drop during the mixing process. The two-way arrangement of obstacles is more effective at inducing secondary vortices and enhancing fluid mixing than the one-way arrangement, with triangular obstacles outperforming rhombic and cylindrical ones in promoting fluid mixing. With a bidirectional layout, triangular shape, and obstacle size of D=150 µm, the TSM achieves a mixing index between 0.85 and 0.99 within the Re range of 20 to 100. This research offers valuable insights into the design and optimization of the Tesla micromixer, providing essential guidance for fluid mixing in microfluidic systems.
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来源期刊
CiteScore
7.80
自引率
9.30%
发文量
408
审稿时长
49 days
期刊介绍: Chemical Engineering and Processing: Process Intensification is intended for practicing researchers in industry and academia, working in the field of Process Engineering and related to the subject of Process Intensification.Articles published in the Journal demonstrate how novel discoveries, developments and theories in the field of Process Engineering and in particular Process Intensification may be used for analysis and design of innovative equipment and processing methods with substantially improved sustainability, efficiency and environmental performance.
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