白细胞介素-1 β在炎症中的作用和免疫靶向治疗的潜力

Pharmacological Research - Reports Pub Date : 2025-03-01 Epub Date: 2025-01-09 DOI:10.1016/j.prerep.2025.100027
Syed Ali Wijdan , Syed Muhammad Nasir Abbas Bokhari , Jenelle Alvares , Varisha Latif
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引用次数: 0

摘要

由于白细胞介素-1β (IL-1β)在不同疾病中介导炎症和组织损伤的关键作用,它已成为一个重要的治疗靶点。本研究对IL-1β发挥重要作用的条件进行了全面的回顾,并总结了旨在抑制其活性的新的和正在进行的治疗方法。此外,我们探索了目前可用的IL-1β靶向治疗,如Canakinumab和Anakinra等IL-1抑制剂,并解释了它们在分子水平上减轻炎症的作用。IL-1β靶向治疗炎症性疾病是有益的,但也存在缺点,包括需要定制治疗计划,耐药和令人不快的影响。这项研究还强调了IL-1β靶向治疗的最新进展,揭示了新的方法。
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The role of interleukin-1 beta in inflammation and the potential of immune-targeted therapies
Interleukin-1 beta (IL-1β) has emerged as an important therapeutic target, due to its key role in mediating inflammation and tissue damage in different disorders. This study presents a thorough review of the conditions in which (IL-1β) is playing an important role and a summary of the new and ongoing treatments aimed at suppressing its activity. Furthermore, we explored currently available IL-1β targeted treatments, such as IL-1 inhibitors like Canakinumab and Anakinra, and also explained their work at molecular level in reducing inflammation. IL-1β is targeted in inflammatory illnesses in treatment that are beneficial, but there are drawbacks as well which includes the requirement for customized treatment plans, drug resistance, and unpleasant effects. This study also underlines the recent advancements in IL-1β targeted therapies, shedding light on novel approaches.
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