Ahmed AlSarori , Abdurrahman Mustafa , Hasan Akyıldız , Ismail Cihan Kaya , Gulcihan Guzel Kaya
{"title":"非化学计量FeS2纳米颗粒作为光热和光动力复合抗菌药物的研究","authors":"Ahmed AlSarori , Abdurrahman Mustafa , Hasan Akyıldız , Ismail Cihan Kaya , Gulcihan Guzel Kaya","doi":"10.1016/j.jphotochem.2024.116260","DOIUrl":null,"url":null,"abstract":"<div><div>In this study, non-stoichiometric FeS<sub>2</sub> nanoparticles were synthesized <em>via</em> hot-injection method and evaluated as dual effect antibacterial agent. Non-stoichiometric FeS<sub>2</sub> nanoparticles were achieved by altering the molar ratio of the precursors (i.e., Fe-source and S-source). X-ray photoelectron spectroscopy (XPS) analysis revealed that Fe/S ratio in the FeS<sub>2</sub> nanoparticles were 1.012:2, 0.960:2, 0.905:2, and 0.900:2 for the samples with Fe-source to S-source ratios of 1/6, 1/8, 1/10, and 1/12, respectively. In the case of Fe/S: 0.900:2, the temperature increased up to about 53 °C (photothermal conversion efficiency: 52.6 %) in addition to reactive oxygen species (ROS) generation under 808 nm near-infrared (NIR) light irradiation. Based on the <em>in vitro</em> antibacterial activity tests, non-stoichiometric FeS<sub>2</sub> nanoparticles exhibited promising antibacterial activity against <em>Escherichia coli</em> (98.00%) and <em>Staphylococcus aureus</em> (99.89%) due to the synergistic effects of ROS formation and hyperthermia. The non-stoichiometric FeS<sub>2</sub> nanoparticles can be considered as high potential antibacterial material under NIR irradiation.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"462 ","pages":"Article 116260"},"PeriodicalIF":4.7000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Non-Stoichiometric FeS2 nanoparticles as antibacterial agents with combined photothermal and photodynamic effect\",\"authors\":\"Ahmed AlSarori , Abdurrahman Mustafa , Hasan Akyıldız , Ismail Cihan Kaya , Gulcihan Guzel Kaya\",\"doi\":\"10.1016/j.jphotochem.2024.116260\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>In this study, non-stoichiometric FeS<sub>2</sub> nanoparticles were synthesized <em>via</em> hot-injection method and evaluated as dual effect antibacterial agent. Non-stoichiometric FeS<sub>2</sub> nanoparticles were achieved by altering the molar ratio of the precursors (i.e., Fe-source and S-source). X-ray photoelectron spectroscopy (XPS) analysis revealed that Fe/S ratio in the FeS<sub>2</sub> nanoparticles were 1.012:2, 0.960:2, 0.905:2, and 0.900:2 for the samples with Fe-source to S-source ratios of 1/6, 1/8, 1/10, and 1/12, respectively. In the case of Fe/S: 0.900:2, the temperature increased up to about 53 °C (photothermal conversion efficiency: 52.6 %) in addition to reactive oxygen species (ROS) generation under 808 nm near-infrared (NIR) light irradiation. Based on the <em>in vitro</em> antibacterial activity tests, non-stoichiometric FeS<sub>2</sub> nanoparticles exhibited promising antibacterial activity against <em>Escherichia coli</em> (98.00%) and <em>Staphylococcus aureus</em> (99.89%) due to the synergistic effects of ROS formation and hyperthermia. The non-stoichiometric FeS<sub>2</sub> nanoparticles can be considered as high potential antibacterial material under NIR irradiation.</div></div>\",\"PeriodicalId\":16782,\"journal\":{\"name\":\"Journal of Photochemistry and Photobiology A-chemistry\",\"volume\":\"462 \",\"pages\":\"Article 116260\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Photochemistry and Photobiology A-chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1010603024008049\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Photochemistry and Photobiology A-chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1010603024008049","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/2 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Non-Stoichiometric FeS2 nanoparticles as antibacterial agents with combined photothermal and photodynamic effect
In this study, non-stoichiometric FeS2 nanoparticles were synthesized via hot-injection method and evaluated as dual effect antibacterial agent. Non-stoichiometric FeS2 nanoparticles were achieved by altering the molar ratio of the precursors (i.e., Fe-source and S-source). X-ray photoelectron spectroscopy (XPS) analysis revealed that Fe/S ratio in the FeS2 nanoparticles were 1.012:2, 0.960:2, 0.905:2, and 0.900:2 for the samples with Fe-source to S-source ratios of 1/6, 1/8, 1/10, and 1/12, respectively. In the case of Fe/S: 0.900:2, the temperature increased up to about 53 °C (photothermal conversion efficiency: 52.6 %) in addition to reactive oxygen species (ROS) generation under 808 nm near-infrared (NIR) light irradiation. Based on the in vitro antibacterial activity tests, non-stoichiometric FeS2 nanoparticles exhibited promising antibacterial activity against Escherichia coli (98.00%) and Staphylococcus aureus (99.89%) due to the synergistic effects of ROS formation and hyperthermia. The non-stoichiometric FeS2 nanoparticles can be considered as high potential antibacterial material under NIR irradiation.
期刊介绍：
JPPA publishes the results of fundamental studies on all aspects of chemical phenomena induced by interactions between light and molecules/matter of all kinds.
All systems capable of being described at the molecular or integrated multimolecular level are appropriate for the journal. This includes all molecular chemical species as well as biomolecular, supramolecular, polymer and other macromolecular systems, as well as solid state photochemistry. In addition, the journal publishes studies of semiconductor and other photoactive organic and inorganic materials, photocatalysis (organic, inorganic, supramolecular and superconductor).
The scope includes condensed and gas phase photochemistry, as well as synchrotron radiation chemistry. A broad range of processes and techniques in photochemistry are covered such as light induced energy, electron and proton transfer; nonlinear photochemical behavior; mechanistic investigation of photochemical reactions and identification of the products of photochemical reactions; quantum yield determinations and measurements of rate constants for primary and secondary photochemical processes; steady-state and time-resolved emission, ultrafast spectroscopic methods, single molecule spectroscopy, time resolved X-ray diffraction, luminescence microscopy, and scattering spectroscopy applied to photochemistry. Papers in emerging and applied areas such as luminescent sensors, electroluminescence, solar energy conversion, atmospheric photochemistry, environmental remediation, and related photocatalytic chemistry are also welcome.
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