{"title":"冷啤酒激发的多功能纳米酶用于缺血性中风，具有快速血栓清除和持久氢疗法","authors":"Jinlu Wei , Zhibin Zhou , Xinyue Pu , Xuefei Wu , Yuyang Zhang , Tingting Zhong , Wenjing Huang , Zhiwei Zhong , Xiaolei Wang","doi":"10.1016/j.nantod.2025.102636","DOIUrl":null,"url":null,"abstract":"<div><div>Ischemic stroke is a thrombus-inflammatory disease caused by cerebral vascular blockage. The narrow treatment window presents challenges for timely intervention and neurological recovery. Inspired by cold beer, we developed a multifunctional nanozyme (CREKA-MOF@Pd/H<sub>2</sub>-uPA, denoted as CMPd(H)U). After injection, CMPd(H)U efficiently targeted the thrombus and combined with gas therapy to expedite thrombolysis and restore blood flow. Additionally, CMPd(H)U released hydrogen (H<sub>2</sub>) to eliminate reactive oxygen species (ROS), thereby mitigating reperfusion injury. Furthermore, CMPd(H)U demonstrated anti-inflammatory and neuroprotective properties by modulating microglial polarization towards the M2 phenotype and inhibiting neuronal pyroptosis. Animal behavioral experiments confirmed the effectiveness of the system in promoting neuromotor function recovery post-stroke.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102636"},"PeriodicalIF":10.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cold beer-inspired multifunctional nanozyme for ischemic stroke with rapid thrombus clearance and long-lasting hydrogen therapy\",\"authors\":\"Jinlu Wei , Zhibin Zhou , Xinyue Pu , Xuefei Wu , Yuyang Zhang , Tingting Zhong , Wenjing Huang , Zhiwei Zhong , Xiaolei Wang\",\"doi\":\"10.1016/j.nantod.2025.102636\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Ischemic stroke is a thrombus-inflammatory disease caused by cerebral vascular blockage. The narrow treatment window presents challenges for timely intervention and neurological recovery. Inspired by cold beer, we developed a multifunctional nanozyme (CREKA-MOF@Pd/H<sub>2</sub>-uPA, denoted as CMPd(H)U). After injection, CMPd(H)U efficiently targeted the thrombus and combined with gas therapy to expedite thrombolysis and restore blood flow. Additionally, CMPd(H)U released hydrogen (H<sub>2</sub>) to eliminate reactive oxygen species (ROS), thereby mitigating reperfusion injury. Furthermore, CMPd(H)U demonstrated anti-inflammatory and neuroprotective properties by modulating microglial polarization towards the M2 phenotype and inhibiting neuronal pyroptosis. Animal behavioral experiments confirmed the effectiveness of the system in promoting neuromotor function recovery post-stroke.</div></div>\",\"PeriodicalId\":395,\"journal\":{\"name\":\"Nano Today\",\"volume\":\"61 \",\"pages\":\"Article 102636\"},\"PeriodicalIF\":10.7000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano Today\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1748013225000088\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1748013225000088","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/11 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Cold beer-inspired multifunctional nanozyme for ischemic stroke with rapid thrombus clearance and long-lasting hydrogen therapy
Ischemic stroke is a thrombus-inflammatory disease caused by cerebral vascular blockage. The narrow treatment window presents challenges for timely intervention and neurological recovery. Inspired by cold beer, we developed a multifunctional nanozyme (CREKA-MOF@Pd/H2-uPA, denoted as CMPd(H)U). After injection, CMPd(H)U efficiently targeted the thrombus and combined with gas therapy to expedite thrombolysis and restore blood flow. Additionally, CMPd(H)U released hydrogen (H2) to eliminate reactive oxygen species (ROS), thereby mitigating reperfusion injury. Furthermore, CMPd(H)U demonstrated anti-inflammatory and neuroprotective properties by modulating microglial polarization towards the M2 phenotype and inhibiting neuronal pyroptosis. Animal behavioral experiments confirmed the effectiveness of the system in promoting neuromotor function recovery post-stroke.
期刊介绍：
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.
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