{"title":"建立了采用乙醇基结晶法和悬浮法纯化α -硫辛酸衍生物组氨酸锌钠二硫代辛酰胺的工艺","authors":"Naoya Ohmori, Takamitsu Miyagi, Toshiaki Nakano, Simon Peter Bahau, Yohei Kono, Toshikazu Adachi, Satoshi Hiratsuka, Shigeru Goto, Masafumi Inomata, Takeshi Goto","doi":"10.1007/s13738-024-03151-2","DOIUrl":null,"url":null,"abstract":"<div><p>Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well defined as a therapy for preventing diabetic polyneuropathies, scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age.</p><p>Sodium zinc histidine dithiooctanamide (DHL-HisZn_Na) is a water-soluble substance, with strong antioxidant and anti-inflammatory properties, similar to α-lipoic acid with histidine bound to α-lipoic acid and zinc chelated with sulfur atoms. DHL-HisZn_Na slowly loses its stability under dry conditions in the dark and under refrigeration. Purification is essential for use after long-term storage. In this study, ethanol crystallization and suspension methods were utilized in development for the first time as purification methods for DHL-HisZn_Na.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"22 2","pages":"325 - 335"},"PeriodicalIF":2.3000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Establishment of purification techniques for alpha-lipoic acid derivative, sodium zinc histidine dithiooctanamide using ethanol-based crystallization and suspension methods\",\"authors\":\"Naoya Ohmori, Takamitsu Miyagi, Toshiaki Nakano, Simon Peter Bahau, Yohei Kono, Toshikazu Adachi, Satoshi Hiratsuka, Shigeru Goto, Masafumi Inomata, Takeshi Goto\",\"doi\":\"10.1007/s13738-024-03151-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well defined as a therapy for preventing diabetic polyneuropathies, scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age.</p><p>Sodium zinc histidine dithiooctanamide (DHL-HisZn_Na) is a water-soluble substance, with strong antioxidant and anti-inflammatory properties, similar to α-lipoic acid with histidine bound to α-lipoic acid and zinc chelated with sulfur atoms. DHL-HisZn_Na slowly loses its stability under dry conditions in the dark and under refrigeration. Purification is essential for use after long-term storage. In this study, ethanol crystallization and suspension methods were utilized in development for the first time as purification methods for DHL-HisZn_Na.</p></div>\",\"PeriodicalId\":676,\"journal\":{\"name\":\"Journal of the Iranian Chemical Society\",\"volume\":\"22 2\",\"pages\":\"325 - 335\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-12-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Iranian Chemical Society\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13738-024-03151-2\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Iranian Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13738-024-03151-2","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Establishment of purification techniques for alpha-lipoic acid derivative, sodium zinc histidine dithiooctanamide using ethanol-based crystallization and suspension methods
Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well defined as a therapy for preventing diabetic polyneuropathies, scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age.
Sodium zinc histidine dithiooctanamide (DHL-HisZn_Na) is a water-soluble substance, with strong antioxidant and anti-inflammatory properties, similar to α-lipoic acid with histidine bound to α-lipoic acid and zinc chelated with sulfur atoms. DHL-HisZn_Na slowly loses its stability under dry conditions in the dark and under refrigeration. Purification is essential for use after long-term storage. In this study, ethanol crystallization and suspension methods were utilized in development for the first time as purification methods for DHL-HisZn_Na.
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JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
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