通过虚拟运动缓解肺癌患者的衰退(MoVE with lung cancer) -一种有希望的方法，可以增强生理力量，改善身体成分，并建立在现有证据的基础上

IF 4.4 2区医学 Q1 ONCOLOGY Lung Cancer Pub Date : 2025-03-01 Epub Date: 2025-02-03 DOI:10.1016/j.lungcan.2025.108418

Ying Wang , Rafael A. Fujita , Natalie Fujisawa , Janessa Laskin , Pat Camp , Sarah Yeo , Gillian V.H. Smith , Kendra Zadravec , Kelly Mackenzie , Kristin L. Campbell

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引用次数: 0

摘要

运动可以缓解癌症患者身体功能的下降，但针对晚期肺癌患者的面对面运动项目往往缺乏招募和保留。这项前瞻性研究评估了虚拟运动对晚期肺癌患者的可行性。方法虚拟运动（MoVE）对肺癌患者衰退的缓解是一项前瞻性、单组、可行性研究。加拿大不列颠哥伦比亚省接受全身治疗的晚期肺癌患者参加了一项为期12周的团体锻炼计划，该计划每周通过Zoom提供两次。可行性测量包括应计、招募率、出勤率、依从性、减员、不良事件和群体归属。通过对身体功能、心血管健康、身体成分和生活质量的影响来评估疗效。结果纳入患者27例，中位年龄66岁。大多数患者患有腺癌（92%），接受靶向治疗（73%）。招募率为61%，流失率为4%，出勤率为87%，坚持率为96%。步态速度（Z = 2.759, p = 0.006）、30秒站立椅(Z = 3.810, p <；0.001)， 30秒肱二头肌弯曲(Z = 4.209, p <；0.001)， 8英尺计时起来和走（Z = - 3.148, p = 0.002）， 6分钟步行测试（Z = 3.124, p = 0.002）和生活质量（FACT-G事后p = 0.005）。参与者的骨骼肌指数增加了0.9 cm2 （p = 0.033）。参与者满意度高（4.6/5）。结论：针对晚期肺癌患者的一项为期12周的虚拟监督运动计划显示出较高的出勤率和依从性，身体功能显著改善，参与者反馈积极。这些结果表明，在晚期肺癌的全身治疗期间，身体功能可以维持或改善。

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Mitigation of decline with virtual exercise with lung cancer (MoVE with lung cancer) − A promising approach to enhance physiological strength, improve body composition, and build upon current evidence

Introduction

Exercise can mitigate declines in physical function for patients with cancer, but in-person exercise programs for patients with advanced lung cancer often face low recruitment and retention. This prospective study assessed the feasibility of virtual exercise for patients with advanced lung cancer.

Methods

Mitigation of decline with Virtual Exercise (MoVE) with Lung Cancer was a prospective, single-arm, feasibility study. Patients with advanced lung cancer undergoing systemic therapy in British Columbia, Canada participated in a 12-week group exercise program delivered twice weekly via Zoom. Feasibility measures included accrual, recruitment rate, attendance, adherence, attrition, adverse events, and group belongingness. Efficacy was assessed via effect on physical function, cardiovascular fitness, body composition, and quality of life (QoL).

Results

Twenty-seven patients were enrolled (median age = 66 years). Most had adenocarcinoma (92 %) and were on targeted therapy (73 %). Recruitment rate was 61 %, attrition 4 %, attendance 87 %, and adherence 96 %. Significant improvements were seen in gait speed (Z = 2.759, p = 0.006), 30-second chair stand (Z = 3.810, p < 0.001), 30-second bicep curl (Z = 4.209, p < 0.001), 8-foot timed up and go (Z = −3.148, p = 0.002), six minute walk test (Z = 3.124, p = 0.002), and QoL (FACT-G post hoc p = 0.005). Participants’ skeletal muscle index increased by 0.9 cm² (p = 0.033). Participant satisfaction was high (4.6/5).

Conclusions

A 12-week virtually supervised exercise program for patients with advanced lung cancer showed high attendance and adherence, with significant improvements in physical function and positive participant feedback. These results demonstrate that physical function can be maintained or improved during systemic treatments for advanced lung cancer.

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来源期刊

Lung Cancer 医学-呼吸系统

CiteScore

9.40

自引率

3.80%

发文量

407

审稿时长

25 days

期刊介绍： Lung Cancer is an international publication covering the clinical, translational and basic science of malignancies of the lung and chest region.Original research articles, early reports, review articles, editorials and correspondence covering the prevention, epidemiology and etiology, basic biology, pathology, clinical assessment, surgery, chemotherapy, radiotherapy, combined treatment modalities, other treatment modalities and outcomes of lung cancer are welcome.