胸腹动脉瘤腔内修复术的手术量与胸腹动脉瘤腔内修复术后的预后相关,而与肾旁修复术无关。

IF 3.6 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Journal of Vascular Surgery Pub Date : 2025-06-01 Epub Date: 2025-02-04 DOI:10.1016/j.jvs.2025.01.209
Ariela Zenilman MD , Kirsten D. Dansey MD, MPH , Sara L. Zettervall MD, MPH , Marc L. Schermerhorn MD , Hiroo Takayama MD, PhD , Virendra I. Patel MD, MPH , Thomas F.X. O’Donnell MD
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引用次数: 0

摘要

背景:胸腹主动脉瘤(eTAAA)血管内修复仍然是血管外科技术上更具挑战性的方面之一,具有显著的死亡率、脊髓缺血(SCI)和终末器官损伤的风险。虽然开窗装置可用于动脉瘤旁,但目前在美国市场上还没有商用的eTAAA装置。因此,我们研究了肾旁修复的体积如何转化为这些更复杂的动脉瘤的结果。方法:我们研究了2014-2021年血管质量倡议中所有的eTAAA修复(Crawford 1-3型),并根据其平均年eTAAA容量和血管内肾旁容积将外科医生分为四分位数。我们的主要终点是胸腹生活改变事件(tale -围手术期死亡、卒中、永久性脊髓损伤和透析的复合)。我们采用混合效应逻辑回归聚类,由中心和外科医生。结果:我们从607名外科医生中确定了5335例修复,400名外科医生的年平均eTAAA量为2629例。四分位数1涉及每年12次维修。高四分位数的修复是针对较大的动脉瘤,更常用的是分期修复,利用脊髓引流,更常用的是医师改良的内移植物,而小容量的外科医生最常用的是平行移植。容积较大的外科医生总的手术时间、透视时间和总造影剂较短。随着手术量的增加,技术成功率也同样增加。在校正分析中,围手术期死亡、TALE、中风、急性肾损伤和主要心脏不良事件的发生率在容积最高的四分位数中均低于容积最低的四分位数。然而,在考虑eTAAA容积后,外科医生血管内肾旁修复容积与任何术后结果无关,肾旁容积与eTAAA容积之间没有显著的相互作用。在容积前两个四分位数的患者中,中期死亡率最低(HR 0.77 [0.61-0.97], P = 0.024)。结论:外科医生的eTAAA经验显示,容量-预后对术后即刻和以患者为中心的永久性预后有很强的影响。然而,治疗范围较小的动脉瘤的经验并不能直接转化为胸腹动脉瘤。需要进一步的研究来评估商业移植物的可用性和修复类型在这些发现中的作用。
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Surgeon volumes of endovascular thoracoabdominal aneurysm repairs, but not juxtarenal repairs, are associated with outcomes following endovascular repair of thoracoabdominal aneurysms

Objective

Endovascular thoracoabdominal aortic aneurysm (eTAAA) repair remains one of the more technically challenging aspect of vascular surgery, with significant risk of mortality, spinal cord ischemia, and end organ damage. Although fenestrated devices are available for juxtarenal aneurysms, there are no commercially available eTAAA devices on the United States market currently. We therefore studied how the volume of juxtarenal repairs would translate to outcomes of these more complicated aneurysms.

Methods

We studied all eTAAA repairs (Crawford type 1-3) in the Vascular Quality Initiative from 2014 to 2021 and categorized surgeons into quartiles based on their average annual eTAAA volume and endovascular juxtarenal volume. Our primary outcome was thoracoabdominal life altering events (composite of perioperative death, stroke, permanent spinal cord ischemia, and dialysis). We employed mixed effects logistic regression clustering by center and surgeon.

Results

We identified 5335 repairs from 607 surgeons, with annual average eTAAA volumes of 2629 from 400 surgeons. Quartile 1 involved less than two repairs and quartile 4 involved >12 repairs per year. Repairs at higher quartiles were for larger aneurysms, more commonly employed staged repairs, utilized spinal drains, and more frequently utilized physician-modified endografts, whereas low-volume surgeons most commonly employed parallel grafting. Higher volume surgeons had overall shorter procedural times, fluoroscopy time, and less total contrast. Technical success similarly increased as procedure volume increased. In adjusted analyses, rates of perioperative death, thoracoabdominal life altering events, stroke, acute kidney injury, and major adverse cardiac events were all lower in the highest volume quartile compared with the lowest. However, after accounting for eTAAA volume, surgeon volume of endovascular juxtarenal repairs was not associated with any postoperative outcome, and there was no significant interaction between juxtarenal and eTAAA volume. Medium-term mortality was lowest in patients treated in the top two quartiles of volume (hazard ratio, 0.77; 95% confidence interval, 0.61-0.97; P = .024).

Conclusions

Surgeon eTAAA experience shows a strong volume-outcome effect on outcomes in the immediate post operative period and in permanent patient-centered outcomes. However, experience in less extensive aneurysms did not directly translate to thoracoabdominal aneurysms. Further study is needed to evaluate the role that commercial graft availability and repair type contributes to these findings.
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来源期刊
CiteScore
7.70
自引率
18.60%
发文量
1469
审稿时长
54 days
期刊介绍: Journal of Vascular Surgery ® aims to be the premier international journal of medical, endovascular and surgical care of vascular diseases. It is dedicated to the science and art of vascular surgery and aims to improve the management of patients with vascular diseases by publishing relevant papers that report important medical advances, test new hypotheses, and address current controversies. To acheive this goal, the Journal will publish original clinical and laboratory studies, and reports and papers that comment on the social, economic, ethical, legal, and political factors, which relate to these aims. As the official publication of The Society for Vascular Surgery, the Journal will publish, after peer review, selected papers presented at the annual meeting of this organization and affiliated vascular societies, as well as original articles from members and non-members.
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