Qi Lin MSc , Huan Chen MSc , Shuyao Zheng MSc , Lingkang Lin MSc , Song Zhu PhD
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A random-effects meta-analysis model was used, and pooled effect estimates were obtained by comparing the standardized mean difference (α=.05).</div></div><div><h3>Results</h3><div><span>A total of 61 studies with 9 different types of antibacterial agent were included in the qualitative and quantitative analyses. The meta-analysis indicated that treatment with metal-based inorganic antibacterial agents improved both the immediate and long-term bond strength values (</span><em>P</em><span><span><.05). Moreover, incorporating carbon-based substances, quaternary ammonium compounds, </span>chlorhexidine<span>, methacrylate derivatives, and antibiotics enhanced the long-term bond strength of the resin composites to dentin (</span></span><em>P</em><span><span><.05). Subgroup analysis indicated that including metal-based inorganic antibacterial agents, quaternary ammonium compounds, and </span>methacrylate derivatives in etch-and-rinse (ER) adhesives improved dentin bond strength (</span><em>P</em><.05), whereas carbon-based materials in self-etching (SE) adhesives showed better bonding performance.</div></div><div><h3>Conclusions</h3><div><span>The introduction of some antibacterial agents into the bonding system improved in vitro bond strength and inhibited bacterial growth. However, clinical trials should be conducted to verify in vivo </span>antibacterial effects and bond strength.</div></div>","PeriodicalId":16866,"journal":{"name":"Journal of Prosthetic Dentistry","volume":"134 6","pages":"Pages 2117-2132"},"PeriodicalIF":4.8000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of antibacterial agents on dentin bonding system: A systematic review and meta-analysis\",\"authors\":\"Qi Lin MSc , Huan Chen MSc , Shuyao Zheng MSc , Lingkang Lin MSc , Song Zhu PhD\",\"doi\":\"10.1016/j.prosdent.2025.01.014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Statement of problem</h3><div>Research on antibacterial dental adhesives has increased over the last few years. However, whether antibacterial agents improve the efficacy of dentin bonding has not yet been determined.</div></div><div><h3>Purpose</h3><div>The purpose of this systematic review and meta-analysis was to evaluate whether antibacterial agents improve the efficacy of dentin bonding at the resin-dentin interface and to identify possible mechanisms.</div></div><div><h3>Material and methods</h3><div>Studies published within the last 10 years up to April 2024 were searched in 5 databases: PubMed (MedLine), EMBASE, Scopus, Web of Science, and Cochrane Library. A random-effects meta-analysis model was used, and pooled effect estimates were obtained by comparing the standardized mean difference (α=.05).</div></div><div><h3>Results</h3><div><span>A total of 61 studies with 9 different types of antibacterial agent were included in the qualitative and quantitative analyses. The meta-analysis indicated that treatment with metal-based inorganic antibacterial agents improved both the immediate and long-term bond strength values (</span><em>P</em><span><span><.05). Moreover, incorporating carbon-based substances, quaternary ammonium compounds, </span>chlorhexidine<span>, methacrylate derivatives, and antibiotics enhanced the long-term bond strength of the resin composites to dentin (</span></span><em>P</em><span><span><.05). Subgroup analysis indicated that including metal-based inorganic antibacterial agents, quaternary ammonium compounds, and </span>methacrylate derivatives in etch-and-rinse (ER) adhesives improved dentin bond strength (</span><em>P</em><.05), whereas carbon-based materials in self-etching (SE) adhesives showed better bonding performance.</div></div><div><h3>Conclusions</h3><div><span>The introduction of some antibacterial agents into the bonding system improved in vitro bond strength and inhibited bacterial growth. However, clinical trials should be conducted to verify in vivo </span>antibacterial effects and bond strength.</div></div>\",\"PeriodicalId\":16866,\"journal\":{\"name\":\"Journal of Prosthetic Dentistry\",\"volume\":\"134 6\",\"pages\":\"Pages 2117-2132\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Prosthetic Dentistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022391325000484\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Prosthetic Dentistry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022391325000484","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/6 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
问题陈述：抗菌牙胶的研究在过去几年中有所增加。然而，抗菌药物是否能提高牙本质结合的功效尚未确定。目的：本系统综述和荟萃分析的目的是评估抗菌药物是否能提高树脂-牙本质界面的牙本质结合效果，并确定可能的机制。材料和方法：在PubMed （MedLine）、EMBASE、Scopus、Web of Science和Cochrane Library 5个数据库中检索到截至2024年4月的近10年内发表的研究。采用随机效应荟萃分析模型，通过比较标准化平均差（α= 0.05）获得合并效应估计。结果：共纳入9种不同类型抗菌药物的61项研究进行了定性和定量分析。meta分析表明，金属基无机抗菌剂处理可提高近期和长期结合强度值(p)。结论：在结合系统中引入一些抗菌剂可提高体外结合强度，抑制细菌生长。但是，需要进行临床试验来验证体内抗菌效果和结合强度。
Effect of antibacterial agents on dentin bonding system: A systematic review and meta-analysis
Statement of problem
Research on antibacterial dental adhesives has increased over the last few years. However, whether antibacterial agents improve the efficacy of dentin bonding has not yet been determined.
Purpose
The purpose of this systematic review and meta-analysis was to evaluate whether antibacterial agents improve the efficacy of dentin bonding at the resin-dentin interface and to identify possible mechanisms.
Material and methods
Studies published within the last 10 years up to April 2024 were searched in 5 databases: PubMed (MedLine), EMBASE, Scopus, Web of Science, and Cochrane Library. A random-effects meta-analysis model was used, and pooled effect estimates were obtained by comparing the standardized mean difference (α=.05).
Results
A total of 61 studies with 9 different types of antibacterial agent were included in the qualitative and quantitative analyses. The meta-analysis indicated that treatment with metal-based inorganic antibacterial agents improved both the immediate and long-term bond strength values (P<.05). Moreover, incorporating carbon-based substances, quaternary ammonium compounds, chlorhexidine, methacrylate derivatives, and antibiotics enhanced the long-term bond strength of the resin composites to dentin (P<.05). Subgroup analysis indicated that including metal-based inorganic antibacterial agents, quaternary ammonium compounds, and methacrylate derivatives in etch-and-rinse (ER) adhesives improved dentin bond strength (P<.05), whereas carbon-based materials in self-etching (SE) adhesives showed better bonding performance.
Conclusions
The introduction of some antibacterial agents into the bonding system improved in vitro bond strength and inhibited bacterial growth. However, clinical trials should be conducted to verify in vivo antibacterial effects and bond strength.
期刊介绍：
The Journal of Prosthetic Dentistry is the leading professional journal devoted exclusively to prosthetic and restorative dentistry. The Journal is the official publication for 24 leading U.S. international prosthodontic organizations. The monthly publication features timely, original peer-reviewed articles on the newest techniques, dental materials, and research findings. The Journal serves prosthodontists and dentists in advanced practice, and features color photos that illustrate many step-by-step procedures. The Journal of Prosthetic Dentistry is included in Index Medicus and CINAHL.
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