Rational Design of Palladium and Platinum Chemosensors for Bio-Applications

Palladium and platinum are non-endogenous precious group 10 metals that are extensively used for catalytic materials, electronics, and drugs. These heavy metals have recently gained more attention in biomedical applications and drug development. At the same time, concerns arising from metal content in various sample types have provoked chemists to develop reliable analytical tools to evaluate the internalization of these metals. Fluorescence chemosensors serve as crucial tools for analytical chemistry and molecular imaging. In view of this, small molecular fluorescent chemosensors are attractive candidates because of their high sensitivity and non-destructive nature for molecular imaging. This mini-review summarizes recent examples of palladium and platinum chemosensors, and their detection mechanisms are highlighted with the applications used in the studies. Moreover, a brief discussion on sensor design and outlook is given as a reference for future palladium and platinum chemosensor development.