肌生长抑制素基因突变的研究进展:提高肉类产量和在家畜遗传选择中的潜力。

IF 1 Q3 VETERINARY SCIENCES Open Veterinary Journal Pub Date : 2024-12-01 Epub Date: 2024-12-31 DOI:10.5455/OVJ.2024.v14.i12.4
Siti Rani Ayuti, Mirni Lamid, Sunaryo Hadi Warsito, Mohammad Anam Al-Arif, Widya Paramita Lokapirnasari, Zulfi Nur Amrina Rosyada, Sugito Sugito, Muslim Akmal, Rimayanti Rimayanti, Rakhi Gangil, Aswin Rafif Khairullah, Mutasem Abuzahra, Ikechukwu Benjamin Moses, Lili Anggraini
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引用次数: 0

摘要

肌生长抑制素(MSTN)是调控家畜肌肉生长发育的重要基因,影响肉品产量和胴体品质。这篇综述着眼于多种动物的MSTN遗传多样性,包括牛、绵羊、山羊和家禽,重点关注特定突变与表型参数(如肌肉质量和生长速度)之间的相关性。MSTN基因的突变与诸如更大的体重和更高的肉质等理想特征有关,使其成为育种计划中遗传选择的理想候选者。携带这种突变的动物经常更有效地将饲料转化为肌肉,从而以更少的饲料投入实现更快的生长。这对寻求在提高产量的同时降低饲料成本的种植者是有利的。mstn突变的动物将饲料更有效地转化为肌肉,随着时间的推移降低了生产成本,使它们对商业育种操作更具吸引力。分子遗传学的进步,特别是CRISPR-Cas9技术,使得精确操纵MSTN基因成为可能,从而使小腿的肌肉质量得到增强。本文还研究了MSTN变异对肉类生产效率的影响,以及动物遗传学中的当前问题。本研究综合强调了MSTN在牛育种中的重要性,特别是它作为一种遗传标记在商业养殖中提高产量和肉质的潜力。
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A review of myostatin gene mutations: Enhancing meat production and potential in livestock genetic selection.

Myostatin (MSTN) is an essential gene that regulates muscle growth and development in livestock animals, influencing meat production and carcass quality. This review looks at MSTN genetic diversity in a variety of animals, including cattle, sheep, goats, and poultry, focusing on correlations between particular mutations and phenotypic parameters such as muscle mass and growth rate. Mutations in the MSTN gene have been linked to desirable features such as greater body weight and higher meat quality, making it an ideal candidate for genetic selection in breeding programs. Animals carrying this mutation frequently transform feed into muscle more efficiently, resulting in faster growth with less feed input. This is advantageous for growers seeking to cut feed costs while raising yields. MSTN-mutated animals convert feed into muscle more efficiently, lowering production costs over time and making them more appealing for commercial breeding operations. Advances in molecular genetics, especially CRISPR-Cas9 technology, have made it possible to precisely manipulate the MSTN gene, allowing for the development of calves with enhanced muscle mass. This article also examines the effects of MSTN variation on meat production efficiency, as well as current issues in animal genetics. This research synthesis emphasizes the significance of MSTN in cattle breeding, specifically its potential as a genetic marker to improve production and meat quality in commercial farming.

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来源期刊
Open Veterinary Journal
Open Veterinary Journal VETERINARY SCIENCES-
CiteScore
1.40
自引率
0.00%
发文量
112
审稿时长
12 weeks
期刊介绍: Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.
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