Barakat Alrashdi, Hussam Askar, Mousa Germoush, Maged Fouda, Ibrahim Abdel-Farid, Diaa Massoud, Sarah Alzwain, Mohamed H A Gadelmawla, Mahmoud Ashry
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引用次数: 0
摘要
背景：天然材料通常是药物开发的良好选择，无论其来源如何。姜黄素可以增强抗氧化能力，预防糖尿病。目的：探讨姜黄素nps （curcumin-NPs）对链脲霉素诱导的糖尿病大鼠可能的抗炎和抗糖尿病作用。方法：随机选取4组大鼠；(1)标准对照组，(2)cu - nps组给予大鼠常规食物，每日给予5 mg/kg cu - nps； (3) STZ组糖尿病大鼠为阳性对照；(4)STZ~ cu - nps组为糖尿病大鼠，给予5 mg/kg/d的cu - nps。结果：治疗6周后，糖尿病动物体内葡萄糖、肿瘤坏死因子tnf - α、白细胞介素1β (il -1 β)、白细胞介素4、白细胞介素6、白细胞介素10、丙二醛（MDA）、一氧化氮（NO）水平明显降低。同时胰岛素、CAT、GPx、GSH、SOD水平均显著升高，接近健康动物水平。同样，免疫组织化学分析显示，胰岛β细胞的胰岛素分泌增加，表明血糖控制得到改善，最终葡萄糖被糖酵解；它清除自由基和作为抗氧化剂的过程可以解释这种行为。结论：因此，我们的发现有助于潜在的表征和创造新的治疗药物，以预防糖尿病。
Evaluation of the anti-diabetic and anti-inflammatory potentials of curcumin nanoparticle in diabetic rat induced by streptozotocin.
Background: Natural materials are frequently good options for drug development, regardless of their source. It has been demonstrated that curcumin boosts antioxidant capacity and guards against diabetic disorders.
Aim: The current study aimed to evaluate the possible anti-inflammatory and anti-diabetic effects of curcumin-NPs (Cur-NPs) in streptozotocin-induced diabetic rats.
Methods: Four groups of rats were randomly selected; (1) standard control group, (2) Cur-NPs group was given the regular food of rats along with 5 mg/kg of Cur-NPs daily, (3) Diabetic rats in the STZ group served as the positive control, and (4) Included in the STZ~Cur-NPs group were diabetic rats receiving Cur-NPs (5 mg/kg/day).
Results: After receiving Cur-NPs treatment for 6 weeks, the levels of glucose, tumor necrosis factor alpha TNF-alpha, interlukin1 β (IL1β), interlukin-4, interlukin-6, interlukin-10, MDA, and NO in the diabetic animals were significantly reduced. Simultaneously, the levels of insulin, CAT, GPx, GSH, and SOD were significantly increased, approaching the levels of the corresponding healthy animals. Similarly, insulin secretion increased in the islet β-cells as shown by immunohistochemical analysis, indicating improved glycaemic control and eventual glucose commitment to glycolysis; its processes for scavenging free radicals and acting as an antioxidant may explain this behavior.
Conclusion: As a result, our findings aid in the potential characterization and creation of novel therapeutic agents that prevent diabetes.
期刊介绍：
Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.
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