恶唑酮诱导的山羊特应性皮炎免疫反应及石榴皮提取物治疗潜力的探索。

IF 3.2 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animals Pub Date : 2025-02-02 DOI:10.3390/ani15030411

Ahmed Elfadadny, Haney Samir, Ahmed S Mandour, Rokaia F Ragab, Besheer G Elshafey, Fawaz E Alanazi, Helal F Hetta, Ahmad A Alharbi, Abdullah S Albalawi, Suhailah S Aljameel, Maha Abdullah Alwaili, Wedad M Nageeb, Mahmoud H Emam

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引用次数: 0

摘要

特应性皮炎（AD）仍然是一种具有挑战性的疾病，需要有效的模型来研究和治疗探索。在这项研究中，我们采用山羊皮肤模型来评估外用恶唑酮（OX）引发的免疫反应。OX模拟Th2驱动的免疫反应，其典型特征是Th2细胞因子（IL-4和IL-13）表达升高，以及表皮和真皮层中CD3+和CD4+ t细胞的存在放大了单核细胞的浸润。此外，石榴皮提取物（PPE）的应用证明了对氧化氧引起的皮肤改变的缓解作用，表明潜在的治疗益处。这项研究强调了山羊作为研究人类和/或大型动物阿尔茨海默病的可靠和可接近的模型的价值。而个人防护装备剂量的治疗潜力有待进一步探索。

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Oxazolone-Induced Immune Response in Atopic Dermatitis Using a Goat Model and Exploration of the Therapeutic Potential of Pomegranate Peel Extract.

Atopic dermatitis (AD) remains a challenging condition, necessitating effective models for investigation and therapeutic exploration. In this study, we employed a goat skin model to assess the immune response triggered by topical oxazolone (OX) application. The OX simulates a Th2-driven immune reaction typified by elevated Th2 cytokine (IL-4 and IL-13) expression and the infiltration of mononuclear cells magnified by the presence of CD3⁺ and CD4⁺ T-cells in the epidermal and dermal layers. Additionally, the application of pomegranate peel extract (PPE) demonstrated a mitigating effect on OX-induced skin alterations, suggesting potential therapeutic benefits. This study underscores the value of goats as a reliable and accessible model for studying AD in humans and/or large animals. While the therapeutic potential of PPE dosage requires further exploration.

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来源期刊

Animals Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

4.90

自引率

16.70%

发文量

3015

审稿时长

20.52 days

期刊介绍： Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).