{"title":"2-苯并咪唑脲对大鼠胃酸分泌的抑制作用","authors":"S. Trivulzio","doi":"10.1016/S0031-6989(88)80725-2","DOIUrl":null,"url":null,"abstract":"<div><p>2-Benzimidazolylurea (BIU) decreases gastric acid secretion. The antisecretive activity appears to be associated with antihistaminic and antimuscarinic effects.</p><p>The antihistaminic activity of BIU appears from its inhibitory effects on betazole stimulated gastric acid secretion and from its inhibitory activity on the isolated guinea pig auricle stimulated by betazole.</p><p>The antimuscarinic activity of BIU appears from several experiments: this molecule decreases gastric acid secretion stimulated by carbachol in rats, depresses the neostigmine-stimulated motility of duodenum in the anaesthetized cat, lessens the hypertonus of isolated guinea pig trachea caused by pylocarpine and also inhibits guinea pig ileum activity stimulated by acetylcholine.</p><p>BIU probably depresses gastric acid secretion by interferring with both histamine and acetylcholine receptors.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1035-1046"},"PeriodicalIF":0.0000,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80725-2","citationCount":"0","resultStr":"{\"title\":\"Inhibitory activity of 2-benzimidazolylurea on gastric acid secretion in rats\",\"authors\":\"S. Trivulzio\",\"doi\":\"10.1016/S0031-6989(88)80725-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>2-Benzimidazolylurea (BIU) decreases gastric acid secretion. The antisecretive activity appears to be associated with antihistaminic and antimuscarinic effects.</p><p>The antihistaminic activity of BIU appears from its inhibitory effects on betazole stimulated gastric acid secretion and from its inhibitory activity on the isolated guinea pig auricle stimulated by betazole.</p><p>The antimuscarinic activity of BIU appears from several experiments: this molecule decreases gastric acid secretion stimulated by carbachol in rats, depresses the neostigmine-stimulated motility of duodenum in the anaesthetized cat, lessens the hypertonus of isolated guinea pig trachea caused by pylocarpine and also inhibits guinea pig ileum activity stimulated by acetylcholine.</p><p>BIU probably depresses gastric acid secretion by interferring with both histamine and acetylcholine receptors.</p></div>\",\"PeriodicalId\":19810,\"journal\":{\"name\":\"Pharmacological research communications\",\"volume\":\"20 12\",\"pages\":\"Pages 1035-1046\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80725-2\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031698988807252\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological research communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031698988807252","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Inhibitory activity of 2-benzimidazolylurea on gastric acid secretion in rats
2-Benzimidazolylurea (BIU) decreases gastric acid secretion. The antisecretive activity appears to be associated with antihistaminic and antimuscarinic effects.
The antihistaminic activity of BIU appears from its inhibitory effects on betazole stimulated gastric acid secretion and from its inhibitory activity on the isolated guinea pig auricle stimulated by betazole.
The antimuscarinic activity of BIU appears from several experiments: this molecule decreases gastric acid secretion stimulated by carbachol in rats, depresses the neostigmine-stimulated motility of duodenum in the anaesthetized cat, lessens the hypertonus of isolated guinea pig trachea caused by pylocarpine and also inhibits guinea pig ileum activity stimulated by acetylcholine.
BIU probably depresses gastric acid secretion by interferring with both histamine and acetylcholine receptors.
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