异丙烯酰胺的非常规氧化还原-中性区域选择性碘胺化

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-12-17 DOI:10.1002/ajoc.202400667

Zhe Tian, Zhaoxuan Zeng, Hongqiang Xie, Prof. Qing Liu, Dr. Fachao Yan, Prof. Hui Liu

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引用次数: 0

摘要

研究了一种新的异丙烯酰胺的氧化还原中性区域选择性碘胺化反应。在无金属催化剂、碱和氧化剂的情况下，采用碘化盐与咪唑啉复合，实现了allenamides的选择性碘胺化反应。在温和的反应条件下合成了碘取代z -酰胺，产物稳定且易于进一步修饰。

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An Unconventional Redox-Neutral Regioselective Iodoamination of Allenamides

A novel unconventional redox-neutral regioselective iodoamination of allenamides was developed. In the absence of metal catalyst, base and oxidant, the selective iodoamination of allenamides was achieved by using iodide salt in combination with morpholine/imidazole. The Iodide-substituted Z-enamides were synthesized under mild reaction conditions, and the products were stable and highly amenable to further modification.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.