{"title":"分子胶出人意料地模仿了癌症突变的效果","authors":"Jonathan W. Bushman, \n Patrick Ryan Potts","doi":"10.1038/d41586-025-00090-7","DOIUrl":null,"url":null,"abstract":"Many conventional small-molecule drugs work by inhibiting proteins, affecting their function. One small molecule instead imbues a protein with a new function in a mechanism that could inform rational drug design. Protein structures could guide the design of molecular glue degraders.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"639 8053","pages":"42-43"},"PeriodicalIF":48.5000,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Molecular glue unexpectedly mimics the effect of cancer mutations\",\"authors\":\"Jonathan W. Bushman, \\n Patrick Ryan Potts\",\"doi\":\"10.1038/d41586-025-00090-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Many conventional small-molecule drugs work by inhibiting proteins, affecting their function. One small molecule instead imbues a protein with a new function in a mechanism that could inform rational drug design. Protein structures could guide the design of molecular glue degraders.\",\"PeriodicalId\":18787,\"journal\":{\"name\":\"Nature\",\"volume\":\"639 8053\",\"pages\":\"42-43\"},\"PeriodicalIF\":48.5000,\"publicationDate\":\"2025-02-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://www.nature.com/articles/d41586-025-00090-7\",\"RegionNum\":1,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature","FirstCategoryId":"103","ListUrlMain":"https://www.nature.com/articles/d41586-025-00090-7","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Molecular glue unexpectedly mimics the effect of cancer mutations
Many conventional small-molecule drugs work by inhibiting proteins, affecting their function. One small molecule instead imbues a protein with a new function in a mechanism that could inform rational drug design. Protein structures could guide the design of molecular glue degraders.
期刊介绍：
Nature is a prestigious international journal that publishes peer-reviewed research in various scientific and technological fields. The selection of articles is based on criteria such as originality, importance, interdisciplinary relevance, timeliness, accessibility, elegance, and surprising conclusions. In addition to showcasing significant scientific advances, Nature delivers rapid, authoritative, insightful news, and interpretation of current and upcoming trends impacting science, scientists, and the broader public. The journal serves a dual purpose: firstly, to promptly share noteworthy scientific advances and foster discussions among scientists, and secondly, to ensure the swift dissemination of scientific results globally, emphasizing their significance for knowledge, culture, and daily life.
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