Pub Date : 2025-01-17DOI: 10.1038/d41586-025-00125-z
Two researchers, one with bipolar disorder and ADHD, the other with autism, discuss supportive workplaces, building networks, and how and when to disclose diagnoses.
{"title":"How to be a brilliant ally to your neurodivergent lab mate","authors":"","doi":"10.1038/d41586-025-00125-z","DOIUrl":"https://doi.org/10.1038/d41586-025-00125-z","url":null,"abstract":"Two researchers, one with bipolar disorder and ADHD, the other with autism, discuss supportive workplaces, building networks, and how and when to disclose diagnoses.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"29 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-17DOI: 10.1038/d41586-025-00042-1
Vegetation clearing to extract nickel, which is used in renewable technologies, leads to greater carbon emissions than realized.
{"title":"Mines for a clean-energy metal have a surprise climate effect","authors":"","doi":"10.1038/d41586-025-00042-1","DOIUrl":"https://doi.org/10.1038/d41586-025-00042-1","url":null,"abstract":"Vegetation clearing to extract nickel, which is used in renewable technologies, leads to greater carbon emissions than realized.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"15 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-17DOI: 10.1038/d41586-025-00141-z
Research also suggests how to make homes more resilient in the aftermath of California’s deadly blazes.
{"title":"Why fires spread quickly in modern cities ― and how to slow them","authors":"","doi":"10.1038/d41586-025-00141-z","DOIUrl":"https://doi.org/10.1038/d41586-025-00141-z","url":null,"abstract":"Research also suggests how to make homes more resilient in the aftermath of California’s deadly blazes.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"184 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1038/s41586-025-08628-5
Claudio Zeni, Robert Pinsler, Daniel Zügner, Andrew Fowler, Matthew Horton, Xiang Fu, Zilong Wang, Aliaksandra Shysheya, Jonathan Crabbé, Shoko Ueda, Roberto Sordillo, Lixin Sun, Jake Smith, Bichlien Nguyen, Hannes Schulz, Sarah Lewis, Chin-Wei Huang, Ziheng Lu, Yichi Zhou, Han Yang, Hongxia Hao, Jielan Li, Chunlei Yang, Wenjie Li, Ryota Tomioka, Tian Xie
The design of functional materials with desired properties is essential in driving technological advances in areas like energy storage, catalysis, and carbon capture1–3. Generative models provide a new paradigm for materials design by directly generating novel materials given desired property constraints, but current methods have low success rate in proposing stable crystals or can only satisfy a limited set of property constraints 4−11. Here, we present MatterGen, a model that generates stable, diverse inorganic materials across the periodic table and can further be fine-tuned to steer the generation towards a broad range of property constraints. Compared to prior generative models 4,12, structures produced by MatterGen are more than twice as likely to be novel and stable, and more than 10 times closer to the local energy minimum. After fine-tuning, MatterGen successfully generates stable, novel materials with desired chemistry, symmetry, as well as mechanical, electronic and magnetic properties. As a proof of concept, we synthesize one of the generated structures and measure its property value to be within 20 % of our target. We believe that the quality of generated materials and the breadth of MatterGen’s capabilities represent a major advancement towards creating a foundational generative model for materials design.
{"title":"A generative model for inorganic materials design","authors":"Claudio Zeni, Robert Pinsler, Daniel Zügner, Andrew Fowler, Matthew Horton, Xiang Fu, Zilong Wang, Aliaksandra Shysheya, Jonathan Crabbé, Shoko Ueda, Roberto Sordillo, Lixin Sun, Jake Smith, Bichlien Nguyen, Hannes Schulz, Sarah Lewis, Chin-Wei Huang, Ziheng Lu, Yichi Zhou, Han Yang, Hongxia Hao, Jielan Li, Chunlei Yang, Wenjie Li, Ryota Tomioka, Tian Xie","doi":"10.1038/s41586-025-08628-5","DOIUrl":"https://doi.org/10.1038/s41586-025-08628-5","url":null,"abstract":"<p>The design of functional materials with desired properties is essential in driving technological advances in areas like energy storage, catalysis, and carbon capture<sup>1–3</sup>. Generative models provide a new paradigm for materials design by directly generating novel materials given desired property constraints, but current methods have low success rate in proposing stable crystals or can only satisfy a limited set of property constraints <sup>4−11</sup>. Here, we present MatterGen, a model that generates stable, diverse inorganic materials across the periodic table and can further be fine-tuned to steer the generation towards a broad range of property constraints. Compared to prior generative models <sup>4,12</sup>, structures produced by MatterGen are more than twice as likely to be novel and stable, and more than 10 times closer to the local energy minimum. After fine-tuning, MatterGen successfully generates stable, novel materials with desired chemistry, symmetry, as well as mechanical, electronic and magnetic properties. As a proof of concept, we synthesize one of the generated structures and measure its property value to be within 20 % of our target. We believe that the quality of generated materials and the breadth of MatterGen’s capabilities represent a major advancement towards creating a foundational generative model for materials design.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"3 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1038/d41586-025-00148-6
Researchers, governments and others can all play a part in ensuring climate policies remain in the interest of all.
{"title":"Trump will weaken climate action — the rest of the US must not follow suit","authors":"","doi":"10.1038/d41586-025-00148-6","DOIUrl":"https://doi.org/10.1038/d41586-025-00148-6","url":null,"abstract":"Researchers, governments and others can all play a part in ensuring climate policies remain in the interest of all.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"11 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1038/d41586-025-00163-7
Artificial intelligence-designed proteins could block the deadly effects of snake venom. Plus, who are science’s winners and losers under Trump 2.0?
{"title":"Daily briefing: AI-designed proteins offer lifeline for treating snake bites","authors":"","doi":"10.1038/d41586-025-00163-7","DOIUrl":"https://doi.org/10.1038/d41586-025-00163-7","url":null,"abstract":"Artificial intelligence-designed proteins could block the deadly effects of snake venom. Plus, who are science’s winners and losers under Trump 2.0?","PeriodicalId":18787,"journal":{"name":"Nature","volume":"68 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1038/s41586-025-08634-7
Yusha Sun, Xin Wang, Daniel Y. Zhang, Zhijian Zhang, Janardhan P. Bhattarai, Yingqi Wang, Kristen H. Park, Weifan Dong, Yun-Fen Hung, Qian Yang, Feng Zhang, Keerthi Rajamani, Shang Mu, Benjamin C. Kennedy, Yan Hong, Jamie Galanaugh, Abhijeet Sambangi, Sang Hoon Kim, Garrett Wheeler, Tiago Gonçalves, Qing Wang, Daniel Geschwind, Riki Kawaguchi, Angela N. Viaene, Ingo Helbig, Sudha K. Kessler, Ahmet Hoke, Huadong Wang, Fuqiang Xu, Zev A. Binder, H. Isaac Chen, Emily Ling-Lin Pai, Sara Stone, MacLean P. Nasrallah, Kimberly M. Christian, Marc Fuccillo, Nicolas Toni, Zhuhao Wu, Hwai-Jong Cheng, Donald M. O’Rourke, Minghong Ma, Guo-li Ming, Hongjun Song
Glioblastoma (GBM) infiltrates the brain and can be synaptically innervated by neurons, which drives tumor progression1,2. Synaptic inputs onto GBM cells identified so far are largely short-range and glutamatergic3,4. The extent of GBM integration into the brain-wide neuronal circuitry remains unclear. Here we applied rabies virus- and herpes simplex virus-mediated trans-monosynaptic tracing5,6 to systematically investigate circuit integration of human GBM organoids transplanted into adult mice. We found that GBM cells from multiple patients rapidly integrate into diverse local and long-range neural circuits across the brain. Beyond glutamatergic inputs, we identified various neuromodulatory inputs, including synapses between basal forebrain cholinergic neurons and GBM cells. Acute acetylcholine stimulation induces long-lasting elevation of calcium oscillations and transcriptional reprogramming of GBM cells into a more motile state via the metabotropic CHRM3 receptor. CHRM3 activation promotes GBM cell motility, whereas its downregulation suppresses GBM cell motility and prolongs mouse survival. Together, these results reveal the striking capacity for human GBM cells to rapidly and robustly integrate into anatomically diverse neuronal networks of different neurotransmitter systems. Our findings further support a model wherein rapid connectivity and transient activation of upstream neurons may lead to a long-lasting increase in tumor fitness.
{"title":"Brain-wide neuronal circuit connectome of human glioblastoma","authors":"Yusha Sun, Xin Wang, Daniel Y. Zhang, Zhijian Zhang, Janardhan P. Bhattarai, Yingqi Wang, Kristen H. Park, Weifan Dong, Yun-Fen Hung, Qian Yang, Feng Zhang, Keerthi Rajamani, Shang Mu, Benjamin C. Kennedy, Yan Hong, Jamie Galanaugh, Abhijeet Sambangi, Sang Hoon Kim, Garrett Wheeler, Tiago Gonçalves, Qing Wang, Daniel Geschwind, Riki Kawaguchi, Angela N. Viaene, Ingo Helbig, Sudha K. Kessler, Ahmet Hoke, Huadong Wang, Fuqiang Xu, Zev A. Binder, H. Isaac Chen, Emily Ling-Lin Pai, Sara Stone, MacLean P. Nasrallah, Kimberly M. Christian, Marc Fuccillo, Nicolas Toni, Zhuhao Wu, Hwai-Jong Cheng, Donald M. O’Rourke, Minghong Ma, Guo-li Ming, Hongjun Song","doi":"10.1038/s41586-025-08634-7","DOIUrl":"https://doi.org/10.1038/s41586-025-08634-7","url":null,"abstract":"<p>Glioblastoma (GBM) infiltrates the brain and can be synaptically innervated by neurons, which drives tumor progression<sup>1,2</sup>. Synaptic inputs onto GBM cells identified so far are largely short-range and glutamatergic<sup>3,4</sup>. The extent of GBM integration into the brain-wide neuronal circuitry remains unclear. Here we applied rabies virus- and herpes simplex virus-mediated trans-monosynaptic tracing<sup>5,6</sup> to systematically investigate circuit integration of human GBM organoids transplanted into adult mice. We found that GBM cells from multiple patients rapidly integrate into diverse local and long-range neural circuits across the brain. Beyond glutamatergic inputs, we identified various neuromodulatory inputs, including synapses between basal forebrain cholinergic neurons and GBM cells. Acute acetylcholine stimulation induces long-lasting elevation of calcium oscillations and transcriptional reprogramming of GBM cells into a more motile state via the metabotropic CHRM3 receptor. CHRM3 activation promotes GBM cell motility, whereas its downregulation suppresses GBM cell motility and prolongs mouse survival. Together, these results reveal the striking capacity for human GBM cells to rapidly and robustly integrate into anatomically diverse neuronal networks of different neurotransmitter systems. Our findings further support a model wherein rapid connectivity and transient activation of upstream neurons may lead to a long-lasting increase in tumor fitness.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"102 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1038/d41586-024-04069-8
Arachnologist Lauren Esposito develops community platforms to share LGBTQ+ voices and wants to shed light on the overlooked intersectional barriers affecting queer people of colour.
{"title":"Championing queer scientists of colour: ‘I don’t think we’ve scratched the surface on systemic exclusion’","authors":"","doi":"10.1038/d41586-024-04069-8","DOIUrl":"https://doi.org/10.1038/d41586-024-04069-8","url":null,"abstract":"Arachnologist Lauren Esposito develops community platforms to share LGBTQ+ voices and wants to shed light on the overlooked intersectional barriers affecting queer people of colour.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"7 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-15DOI: 10.1038/d41586-025-00050-1
The US federal government can harness science to secure the health, prosperity and safety of Americans and the world.
{"title":"Dear Donald Trump: A letter from Nature on how to make science thrive","authors":"","doi":"10.1038/d41586-025-00050-1","DOIUrl":"https://doi.org/10.1038/d41586-025-00050-1","url":null,"abstract":"The US federal government can harness science to secure the health, prosperity and safety of Americans and the world.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"24 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-15DOI: 10.1038/d41586-025-00044-z
A pair of spacecraft developed by private firms blast off on a single rocket on the risky voyage to the lunar surface.
{"title":"Two companies launch Moon missions together: will they make history?","authors":"","doi":"10.1038/d41586-025-00044-z","DOIUrl":"https://doi.org/10.1038/d41586-025-00044-z","url":null,"abstract":"A pair of spacecraft developed by private firms blast off on a single rocket on the risky voyage to the lunar surface.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"8 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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