可溶性鸟苷酸环化酶作为慢性肾脏疾病药物缓解的直接靶点

IF 21.8 1区医学 Q1 UROLOGY & NEPHROLOGY Kidney international Pub Date : 2025-03-01 Epub Date: 2025-02-19 DOI:10.1016/j.kint.2024.12.011

Mia Jensen , Boye L. Jensen

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引用次数: 0

摘要

在一项临床前大鼠研究中，Lichtenberger等人表明，BAY-60-2770（一种激活可溶性胍基环化酶的药物，通常因氧化应激而失去活性）可能通过缺血再灌注后的血管作用减轻肾脏炎症、损伤和纤维化。在不改变血压的剂量下，肾灌注、血管总反应性和髓微血管直径均得到改善。可溶性胍基环化酶是一个有吸引力的和潜在的未开发的目标，以阻止慢性肾脏疾病的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Soluble guanylate cyclase as a direct target for pharmacologic mitigation of chronic kidney disease

In a preclinical rat study, Lichtenberger et al. show that BAY-60-2770, a drug that activates soluble guanylyl cyclase, often rendered inactive by oxidative stress, mitigates kidney inflammation, injury, and fibrosis, likely by vascular effects after ischemia-reperfusion. Kidney perfusion, overall vascular reactivity, and medullary microvascular diameter are improved by the drug at doses that do not alter blood pressure. Soluble guanylyl cyclase is an attractive and potentially unexploited target to halt progression of chronic kidney disease.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.