Synergistic polyphenol–amino acid nanoparticles: a new strategy for reactive oxygen species management†

Polyphenols exhibit strong antioxidant, and anti-inflammatory but are limited by chemical instability and low bioavailability. To address these challenges, we developed polyphenol–amino acid conjugates that self-assemble into stable nanospheres, enhancing their stability and bioavailability. These nanoparticles demonstrate significantly improved ROS scavenging efficiency and promote cell proliferation in vitro. The incorporation of amino acids enhances biocompatibility and facilitates effective ROS elimination. The polyphenol–amino acid nanoparticles offer a multifaceted therapeutic strategy to mitigate oxidative stress, overcoming traditional antioxidant limitations through advanced nanotechnology. This approach contributes to the development of next-generation wound care solutions with enhanced efficacy and safety profiles.