{"title":"作为治疗阿尔茨海默病的潜在体外乙酰/丁酰胆碱酯酶抑制剂的新型外周吡啶取代钴、铜和锰酞菁","authors":"Halise Yalazan, Gökçe Seyhan, Şeyma Özkan, Burak Barut, Zekeriya Biyiklioglu, Halit Kantekin","doi":"10.1002/aoc.70045","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>In this research, we designed phthalocyanine compounds that are thought to be used as potential acetyl/butyrylcholinesterase inhibitors in the treatment of Alzheimer's disease. First, phthalonitrile compound (<b>PNM-CN</b>), which is the precursor compound for phthalocyanines, was synthesized. Then, by cyclotetramerizing this compound, pyridine-substituted peripheral cobalt (<b>PNM-CoPc</b>), copper (<b>PNM-CuPc</b>), and manganese (<b>PNM-MnClPc</b>) phthalocyanine compounds were synthesized, and their structures were described using mass, NMR (except phthalocyanines), FT-IR, and UV–Vis (except phthalonitrile) spectroscopic techniques. Investigations were carried out into the new pyridine-substituted peripheral (<b>PNM-Cu/Co/MnClPcs</b>) phthalocyanines' in vitro inhibitory properties against butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE). With an IC<sub>50</sub> of 5.95 ± 2.12 μM (AChE) and 0.74 ± 0.01 μM (BuChE), <b>PNM-CuPc</b> showed the most potent inhibitory effect against AChE and BuChE among all compounds.</p>\n </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 3","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New Peripheral Pyridine-Substituted Cobalt, Copper, and Manganese Phthalocyanines as Potential In Vitro Acetyl/Butyrylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease\",\"authors\":\"Halise Yalazan, Gökçe Seyhan, Şeyma Özkan, Burak Barut, Zekeriya Biyiklioglu, Halit Kantekin\",\"doi\":\"10.1002/aoc.70045\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>In this research, we designed phthalocyanine compounds that are thought to be used as potential acetyl/butyrylcholinesterase inhibitors in the treatment of Alzheimer's disease. First, phthalonitrile compound (<b>PNM-CN</b>), which is the precursor compound for phthalocyanines, was synthesized. Then, by cyclotetramerizing this compound, pyridine-substituted peripheral cobalt (<b>PNM-CoPc</b>), copper (<b>PNM-CuPc</b>), and manganese (<b>PNM-MnClPc</b>) phthalocyanine compounds were synthesized, and their structures were described using mass, NMR (except phthalocyanines), FT-IR, and UV–Vis (except phthalonitrile) spectroscopic techniques. Investigations were carried out into the new pyridine-substituted peripheral (<b>PNM-Cu/Co/MnClPcs</b>) phthalocyanines' in vitro inhibitory properties against butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE). With an IC<sub>50</sub> of 5.95 ± 2.12 μM (AChE) and 0.74 ± 0.01 μM (BuChE), <b>PNM-CuPc</b> showed the most potent inhibitory effect against AChE and BuChE among all compounds.</p>\\n </div>\",\"PeriodicalId\":8344,\"journal\":{\"name\":\"Applied Organometallic Chemistry\",\"volume\":\"39 3\",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-02-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Organometallic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/aoc.70045\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Organometallic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/aoc.70045","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
New Peripheral Pyridine-Substituted Cobalt, Copper, and Manganese Phthalocyanines as Potential In Vitro Acetyl/Butyrylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease
In this research, we designed phthalocyanine compounds that are thought to be used as potential acetyl/butyrylcholinesterase inhibitors in the treatment of Alzheimer's disease. First, phthalonitrile compound (PNM-CN), which is the precursor compound for phthalocyanines, was synthesized. Then, by cyclotetramerizing this compound, pyridine-substituted peripheral cobalt (PNM-CoPc), copper (PNM-CuPc), and manganese (PNM-MnClPc) phthalocyanine compounds were synthesized, and their structures were described using mass, NMR (except phthalocyanines), FT-IR, and UV–Vis (except phthalonitrile) spectroscopic techniques. Investigations were carried out into the new pyridine-substituted peripheral (PNM-Cu/Co/MnClPcs) phthalocyanines' in vitro inhibitory properties against butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE). With an IC50 of 5.95 ± 2.12 μM (AChE) and 0.74 ± 0.01 μM (BuChE), PNM-CuPc showed the most potent inhibitory effect against AChE and BuChE among all compounds.
期刊介绍：
All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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