Mei-Li Li , Kun Pang , Lei Qiao , Zhi-Qiang Guan , Chao-Ju Gong , Song-Tao Li , Zhi-Ming Tang , Yi-Ling Zhang , Ji-Cun Ding
{"title":"白藜芦醇影响成纤维细胞的增殖、凋亡和迁移，抑制COL1A1/2和TGFB2/3基因的表达。","authors":"Mei-Li Li , Kun Pang , Lei Qiao , Zhi-Qiang Guan , Chao-Ju Gong , Song-Tao Li , Zhi-Ming Tang , Yi-Ling Zhang , Ji-Cun Ding","doi":"10.1080/10286020.2025.2462610","DOIUrl":null,"url":null,"abstract":"<div><div>Primary fibroblasts isolated from pterygium and skin pathological scar were identified by immunofluorescence staining. It was found by CCK8 and TUNEL that high-dose resveratrol, a Chinese medicine monomer, could inhibit proliferation, promote apoptosis and restrain migration. Explored by whole-transcriptome sequencing and LC-MS/MS, 1531 up-regulated mRNAs, 1022 down-regulated mRNAs, 79 up-regulated proteins and 84 down-regulated proteins were identified in resveratrol-treated pterygium fibroblasts. It was shown by KEGG, GO, PPI and the following bioinformatics analysis that resveratrol may affect proliferation, apoptosis and migration of fibroblast through TGFB2/3 and COL1A1/2.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 9","pages":"Pages 1311-1331"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression\",\"authors\":\"Mei-Li Li , Kun Pang , Lei Qiao , Zhi-Qiang Guan , Chao-Ju Gong , Song-Tao Li , Zhi-Ming Tang , Yi-Ling Zhang , Ji-Cun Ding\",\"doi\":\"10.1080/10286020.2025.2462610\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Primary fibroblasts isolated from pterygium and skin pathological scar were identified by immunofluorescence staining. It was found by CCK8 and TUNEL that high-dose resveratrol, a Chinese medicine monomer, could inhibit proliferation, promote apoptosis and restrain migration. Explored by whole-transcriptome sequencing and LC-MS/MS, 1531 up-regulated mRNAs, 1022 down-regulated mRNAs, 79 up-regulated proteins and 84 down-regulated proteins were identified in resveratrol-treated pterygium fibroblasts. It was shown by KEGG, GO, PPI and the following bioinformatics analysis that resveratrol may affect proliferation, apoptosis and migration of fibroblast through TGFB2/3 and COL1A1/2.</div></div>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":\"27 9\",\"pages\":\"Pages 1311-1331\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1028602025000116\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1028602025000116","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/17 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Resveratrol affects proliferation, apoptosis and migration of fibroblast cells as well as inhibits COL1A1/2 and TGFB2/3 gene expression
Primary fibroblasts isolated from pterygium and skin pathological scar were identified by immunofluorescence staining. It was found by CCK8 and TUNEL that high-dose resveratrol, a Chinese medicine monomer, could inhibit proliferation, promote apoptosis and restrain migration. Explored by whole-transcriptome sequencing and LC-MS/MS, 1531 up-regulated mRNAs, 1022 down-regulated mRNAs, 79 up-regulated proteins and 84 down-regulated proteins were identified in resveratrol-treated pterygium fibroblasts. It was shown by KEGG, GO, PPI and the following bioinformatics analysis that resveratrol may affect proliferation, apoptosis and migration of fibroblast through TGFB2/3 and COL1A1/2.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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