{"title":"保护抑制因子锁定肝细胞身份，阻断肝癌","authors":"","doi":"10.1038/s41588-025-02082-9","DOIUrl":null,"url":null,"abstract":"PROX1 acts as a molecular ‘cell fate guardian’ in hepatocytes, preserving liver cell identity throughout life by actively repressing unwanted plasticity. PROX1 loss impairs liver regeneration and fuels tumor formation, whereas PROX1 activation halts cancer formation and progression, revealing unexpected therapeutic potential.","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"57 3","pages":"494-495"},"PeriodicalIF":29.0000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Safeguard repressor locks hepatocyte identity and blocks liver cancer\",\"authors\":\"\",\"doi\":\"10.1038/s41588-025-02082-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"PROX1 acts as a molecular ‘cell fate guardian’ in hepatocytes, preserving liver cell identity throughout life by actively repressing unwanted plasticity. PROX1 loss impairs liver regeneration and fuels tumor formation, whereas PROX1 activation halts cancer formation and progression, revealing unexpected therapeutic potential.\",\"PeriodicalId\":18985,\"journal\":{\"name\":\"Nature genetics\",\"volume\":\"57 3\",\"pages\":\"494-495\"},\"PeriodicalIF\":29.0000,\"publicationDate\":\"2025-02-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature genetics\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.nature.com/articles/s41588-025-02082-9\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature genetics","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41588-025-02082-9","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
Safeguard repressor locks hepatocyte identity and blocks liver cancer
PROX1 acts as a molecular ‘cell fate guardian’ in hepatocytes, preserving liver cell identity throughout life by actively repressing unwanted plasticity. PROX1 loss impairs liver regeneration and fuels tumor formation, whereas PROX1 activation halts cancer formation and progression, revealing unexpected therapeutic potential.
期刊介绍：
Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation.
Integrative genetic topics comprise, but are not limited to:
-Genes in the pathology of human disease
-Molecular analysis of simple and complex genetic traits
-Cancer genetics
-Agricultural genomics
-Developmental genetics
-Regulatory variation in gene expression
-Strategies and technologies for extracting function from genomic data
-Pharmacological genomics
-Genome evolution
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