真菌蛋白D1通过激活p53/miR-34a信号通路抑制A549细胞的增殖。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL Journal of Natural Medicines Pub Date : 2025-02-18 DOI:10.1007/s11418-024-01869-0

Min-Hui Zhang, Fang Liu, Wen-Hui Gao, Zhao-Kun Liu

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引用次数: 0

摘要

双色肉毒杆菌是一种广泛分布于中国的野生食用肉毒杆菌。我们从双色蓝杆菌中分离出D1蛋白，发现D1蛋白在体外和体内对肺癌A549细胞的生长和增殖都有明显的抑制作用。在本文中，我们发现miR-34a在抑制A549细胞的增殖中起着重要作用。miR-34a是蛋白D1对A549细胞的功能靶点。蛋白D1诱导miR-34a和p53的正反馈调控，进而调控下游的Bcl-2和CDK6，抑制A549细胞的增殖。

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Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway

Boletus bicolor is a kind of wild edible boletus, which is widely distributed in China. We have isolated the protein D1 from B. bicolor, and found that protein D1 has a significant inhibitory effect on the growth and proliferation of lung cancer A549 cells both in vitro and in vivo. In this paper, we found that miR-34a plays an important role in inhibiting the proliferation of A549 cells. miR-34a is the functional target of protein D1 against A549 cells. Protein D1 induces the positive feedback regulation of miR-34a and p53, which further regulates downstream Bcl-2 and CDK6, and inhibits the proliferation of A549 cells.

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.