Ali Gülaydın, Kıvanç İrak, Nihat Şındak, Mustafa Barış Akgül, Özgür Yaşar Çelik, Onur Yıldırım, Maruf Yılmaz, Erman Gülendağ
{"title":"异丙酚和七氟醚麻醉对土耳其毛山羊氧化-抗氧化状态和生化指标影响的研究。","authors":"Ali Gülaydın, Kıvanç İrak, Nihat Şındak, Mustafa Barış Akgül, Özgür Yaşar Çelik, Onur Yıldırım, Maruf Yılmaz, Erman Gülendağ","doi":"10.2460/ajvr.24.10.0309","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of propofol and sevoflurane anesthesia on the oxidant-antioxidant status and biochemical parameters in Turkish hair goats.</p><p><strong>Methods: </strong>The study was conducted from February 15 through March 15, 2024. Seven clinically healthy female Turkish hair goats aged 1 to 2 years with an average live weight of 29.95 (26.1 to 33.8) kg were included. A bolus of propofol (6 mg/kg) was injected IV. The goats were placed in the sternoabdominal position and administered 1% to 3% sevoflurane with 100% oxygen for 2 hours with the help of a vaporizer. Blood samples were collected before and after the administration of propofol and at the 15th, 30th, 60th, and 120th minutes after the start of sevoflurane administration in nonanticoagulated tubes. The oxidant-antioxidant status (serum total antioxidant status, total oxidant status, paraoxonase activity, and arylesterase activity) and biochemical parameters (levels of glucose, AST, GGT, ALT, ALP, LDH, creatine kinase, amylase, lipase, creatinine, urea, uric acid, high-density lipoprotein, low-density lipoprotein, total protein, albumin, total bilirubin, direct bilirubin, magnesium, chlorine, calcium, iron, sodium, phosphorus, and potassium) were evaluated. The heart rate, respiratory rate, and body temperature of the goats were measured using a bedside monitor.</p><p><strong>Results: </strong>Arylesterase activity increased with sevoflurane administration. Changes were observed in heart rate and body temperature as well as in the levels of glucose, creatine kinase, urea, total bilirubin, and potassium at different time intervals of propofol-sevoflurane administration.</p><p><strong>Conclusions: </strong>Propofol-sevoflurane anesthesia has no adverse effects on oxidant-antioxidant status in Turkish hair goats.</p><p><strong>Clinical relevance: </strong>The evaluation of heart rate and body temperature, as well as glucose, creatine kinase, urea, total bilirubin, and potassium levels, must be considered in propofol-sevoflurane anesthesia protocol.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigation of the effects of propofol and sevoflurane anesthesia on oxidant-antioxidant status and biochemical parameters in Turkish hair goats.\",\"authors\":\"Ali Gülaydın, Kıvanç İrak, Nihat Şındak, Mustafa Barış Akgül, Özgür Yaşar Çelik, Onur Yıldırım, Maruf Yılmaz, Erman Gülendağ\",\"doi\":\"10.2460/ajvr.24.10.0309\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the effects of propofol and sevoflurane anesthesia on the oxidant-antioxidant status and biochemical parameters in Turkish hair goats.</p><p><strong>Methods: </strong>The study was conducted from February 15 through March 15, 2024. Seven clinically healthy female Turkish hair goats aged 1 to 2 years with an average live weight of 29.95 (26.1 to 33.8) kg were included. A bolus of propofol (6 mg/kg) was injected IV. The goats were placed in the sternoabdominal position and administered 1% to 3% sevoflurane with 100% oxygen for 2 hours with the help of a vaporizer. Blood samples were collected before and after the administration of propofol and at the 15th, 30th, 60th, and 120th minutes after the start of sevoflurane administration in nonanticoagulated tubes. The oxidant-antioxidant status (serum total antioxidant status, total oxidant status, paraoxonase activity, and arylesterase activity) and biochemical parameters (levels of glucose, AST, GGT, ALT, ALP, LDH, creatine kinase, amylase, lipase, creatinine, urea, uric acid, high-density lipoprotein, low-density lipoprotein, total protein, albumin, total bilirubin, direct bilirubin, magnesium, chlorine, calcium, iron, sodium, phosphorus, and potassium) were evaluated. The heart rate, respiratory rate, and body temperature of the goats were measured using a bedside monitor.</p><p><strong>Results: </strong>Arylesterase activity increased with sevoflurane administration. 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Investigation of the effects of propofol and sevoflurane anesthesia on oxidant-antioxidant status and biochemical parameters in Turkish hair goats.
Objective: To investigate the effects of propofol and sevoflurane anesthesia on the oxidant-antioxidant status and biochemical parameters in Turkish hair goats.
Methods: The study was conducted from February 15 through March 15, 2024. Seven clinically healthy female Turkish hair goats aged 1 to 2 years with an average live weight of 29.95 (26.1 to 33.8) kg were included. A bolus of propofol (6 mg/kg) was injected IV. The goats were placed in the sternoabdominal position and administered 1% to 3% sevoflurane with 100% oxygen for 2 hours with the help of a vaporizer. Blood samples were collected before and after the administration of propofol and at the 15th, 30th, 60th, and 120th minutes after the start of sevoflurane administration in nonanticoagulated tubes. The oxidant-antioxidant status (serum total antioxidant status, total oxidant status, paraoxonase activity, and arylesterase activity) and biochemical parameters (levels of glucose, AST, GGT, ALT, ALP, LDH, creatine kinase, amylase, lipase, creatinine, urea, uric acid, high-density lipoprotein, low-density lipoprotein, total protein, albumin, total bilirubin, direct bilirubin, magnesium, chlorine, calcium, iron, sodium, phosphorus, and potassium) were evaluated. The heart rate, respiratory rate, and body temperature of the goats were measured using a bedside monitor.
Results: Arylesterase activity increased with sevoflurane administration. Changes were observed in heart rate and body temperature as well as in the levels of glucose, creatine kinase, urea, total bilirubin, and potassium at different time intervals of propofol-sevoflurane administration.
Conclusions: Propofol-sevoflurane anesthesia has no adverse effects on oxidant-antioxidant status in Turkish hair goats.
Clinical relevance: The evaluation of heart rate and body temperature, as well as glucose, creatine kinase, urea, total bilirubin, and potassium levels, must be considered in propofol-sevoflurane anesthesia protocol.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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