Manon Porta-Zapata , Susana Carregal-Romero , Jennifer Saliba , Ainhize Urkola-Arsuaga , Claudia Beatriz Miranda Perez de Alejo , Iñaki Orue , Lydia Martínez-Parra , Desirè Di Silvio , Armel Descamps-Mandine , Clément Daviaud , Maelenn Menard , Ameur Hamami , Benjamin Musnier , Julien Cherfan , Axel Codault , Chanez Manseur , Marc Jeannin , David Castejón , Ingrid Fruitier-Arnaudin , Jesús Ruiz-Cabello , Hugo Groult
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To overcome these obstacles, oligosaccharide derivatives (λ-COS) have been successfully applied to the synthesis of stable NP incorporating both, ferrite cores and divalent manganese (Mn<sup>2+</sup>) releasable ions. The acute pro-inflammatory behavior and anticoagulant activity of native λ-CAR were significantly reduced in the case of λ-COS and λ-COS NP, rendering possible their use for medical applications. In vivo MRI studies in mice showed that the λ-COS NP framework is promising for two applications. The first is partial Mn<sup>2+</sup> release into the plasma to achieve intracellular Mn<sup>2+</sup>-based contrast of the myocardium and imaging of the hepatobiliary system. Second, it serves as a novel sugar-based coating that confers suitable pharmacokinetic properties to NP, making it promising for further targeted therapy applications.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (174KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 3","pages":"Pages 1948-1967"},"PeriodicalIF":5.4000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and Characterization of λ‑Carrageenan Oligosaccharide-Based Nanoparticles: Applications in MRI and In Vivo Biodistribution Studies\",\"authors\":\"Manon Porta-Zapata , Susana Carregal-Romero , Jennifer Saliba , Ainhize Urkola-Arsuaga , Claudia Beatriz Miranda Perez de Alejo , Iñaki Orue , Lydia Martínez-Parra , Desirè Di Silvio , Armel Descamps-Mandine , Clément Daviaud , Maelenn Menard , Ameur Hamami , Benjamin Musnier , Julien Cherfan , Axel Codault , Chanez Manseur , Marc Jeannin , David Castejón , Ingrid Fruitier-Arnaudin , Jesús Ruiz-Cabello , Hugo Groult\",\"doi\":\"10.1021/acs.biomac.4c01747\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>λ-type carrageenan (λ-CAR) polysaccharides remain overlooked in the preparation of medical nanoparticles (NP) due to their unsuitable rheological properties and undesired biological effects, although they can also offer advantageous properties. To overcome these obstacles, oligosaccharide derivatives (λ-COS) have been successfully applied to the synthesis of stable NP incorporating both, ferrite cores and divalent manganese (Mn<sup>2+</sup>) releasable ions. The acute pro-inflammatory behavior and anticoagulant activity of native λ-CAR were significantly reduced in the case of λ-COS and λ-COS NP, rendering possible their use for medical applications. In vivo MRI studies in mice showed that the λ-COS NP framework is promising for two applications. The first is partial Mn<sup>2+</sup> release into the plasma to achieve intracellular Mn<sup>2+</sup>-based contrast of the myocardium and imaging of the hepatobiliary system. 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Synthesis and Characterization of λ‑Carrageenan Oligosaccharide-Based Nanoparticles: Applications in MRI and In Vivo Biodistribution Studies
λ-type carrageenan (λ-CAR) polysaccharides remain overlooked in the preparation of medical nanoparticles (NP) due to their unsuitable rheological properties and undesired biological effects, although they can also offer advantageous properties. To overcome these obstacles, oligosaccharide derivatives (λ-COS) have been successfully applied to the synthesis of stable NP incorporating both, ferrite cores and divalent manganese (Mn2+) releasable ions. The acute pro-inflammatory behavior and anticoagulant activity of native λ-CAR were significantly reduced in the case of λ-COS and λ-COS NP, rendering possible their use for medical applications. In vivo MRI studies in mice showed that the λ-COS NP framework is promising for two applications. The first is partial Mn2+ release into the plasma to achieve intracellular Mn2+-based contrast of the myocardium and imaging of the hepatobiliary system. Second, it serves as a novel sugar-based coating that confers suitable pharmacokinetic properties to NP, making it promising for further targeted therapy applications.
期刊介绍：
Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine.
Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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