Chitra R, Shanthi Prince, Ashok Chandrasekaran, Subash Sundar
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摘要

新生儿胆红素过高导致的黄疸仍然是一个令人担忧的问题,尤其是在出生后的第一周。测量血清总胆红素(TSB)水平的常用方法是进行有创血液检测,这种方法既耗时又让新生儿感到不舒服。虽然有无创经皮胆红素仪(TcB),但由于受到其他生物发色团的干扰,往往不够准确。本研究旨在通过开发一种无创系统来改进胆红素评估,该系统使用漫反射光谱和一种新型算法来计算黑色素和血红蛋白等发色团。以胸骨为测量部位,收集了 285 名新生儿的光谱。利用所提出的算法,可以计算出 450、460 和 470 纳米波长处的胆红素浓度。与 TSB 水平相比,建议的方法具有很高的准确性,平均偏差为 -0.10 毫克/分升,在 470 纳米波长处的一致性范围较窄,为 4.85 毫克/分升。
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Development and Validation of a Noninvasive Diffuse Reflectance Spectroscopic Method for Bilirubin Estimation in Neonates.

Jaundice due to excess bilirubin buildup in neonates remains an alarming problem, especially during the very first week of postnatal life. The common method of measuring total serum bilirubin (TSB) levels involves invasive blood testing, which is time-consuming and uncomfortable for neonates. While noninvasive transcutaneous bilirubinometers (TcB) are available, that often lack accuracy due to interference from other biological chromophores. This study aims to improve bilirubin assessment by developing a noninvasive system that uses diffuse reflectance spectroscopy and a novel algorithm accounting for chromophores like melanin and hemoglobin. Focusing on the sternum as the measurement site, spectra are collected from 285 newborns. Using the proposed algorithm, the bilirubin concentration is calculated at 450, 460, and 470 nm. Compared to TSB levels, the proposed method demonstrated strong accuracy with an average bias of -0.10 mg/dL and narrower limits of agreement of 4.85 mg/dL at 470 nm.

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