Cuiyao Xie, Xi Xia, Kai Wang, Jie Yan, Lijun Bai, Liqiong Guo, Xiaoxue Li, Shaowei Wu
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A subgroup meta-analysis was further conducted to explore the potential sources of heterogeneity.</p><p><strong>Results: </strong>In total, 42 eligible studies were included. For each 5 μg/m<sup>3</sup> increase in long-term PM<sub>2.5</sub> exposure, the odds ratios (ORs) were 1.16 (95% CI: 1.04, 1.30; <i>I</i><sup>2</sup> = 95%) and 1.10 (95% CI: 1.03, 1.17; <i>I</i><sup>2</sup> = 95%) for AD and PD, respectively. For each 5 μg/m<sup>3</sup> increase in short-term PM<sub>2.5</sub> exposure, the OR was 1.01 (95% CI: 1.002, 1.01; <i>I</i><sup>2</sup> = 77%) for PD. For each 1 ppb increase in long-term NO<sub>2</sub> exposure, the OR was 1.01 (95% CI: 1.0002, 1.02; <i>I</i><sup>2</sup> = 79%) for PD.</p><p><strong>Conclusion: </strong>Ambient air pollution, particularly PM<sub>2.5</sub>, may contribute to the increased risks of neurodegenerative diseases including AD and PD.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 2","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ambient Air Pollution and Parkinson's Disease and Alzheimer's Disease: An Updated Meta-Analysis.\",\"authors\":\"Cuiyao Xie, Xi Xia, Kai Wang, Jie Yan, Lijun Bai, Liqiong Guo, Xiaoxue Li, Shaowei Wu\",\"doi\":\"10.3390/toxics13020139\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Previous epidemiological evidence regarding the associations between ambient air pollution and two major neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD), remains inconclusive.</p><p><strong>Objective: </strong>This study aimed to evaluate the associations between long-term and short-term exposure to PM<sub>2.5</sub> and PM<sub>10</sub> (i.e., particulate matter with an aerodynamic diameter of, or smaller than, 2.5 μm or 10 μm), nitrogen dioxide (NO<sub>2</sub>), ozone, sulfur dioxide, and carbon monoxide and the risks of AD and PD.</p><p><strong>Methods: </strong>A random-effects model was used to summarize individual effect estimates in the meta-analysis. A subgroup meta-analysis was further conducted to explore the potential sources of heterogeneity.</p><p><strong>Results: </strong>In total, 42 eligible studies were included. For each 5 μg/m<sup>3</sup> increase in long-term PM<sub>2.5</sub> exposure, the odds ratios (ORs) were 1.16 (95% CI: 1.04, 1.30; <i>I</i><sup>2</sup> = 95%) and 1.10 (95% CI: 1.03, 1.17; <i>I</i><sup>2</sup> = 95%) for AD and PD, respectively. For each 5 μg/m<sup>3</sup> increase in short-term PM<sub>2.5</sub> exposure, the OR was 1.01 (95% CI: 1.002, 1.01; <i>I</i><sup>2</sup> = 77%) for PD. For each 1 ppb increase in long-term NO<sub>2</sub> exposure, the OR was 1.01 (95% CI: 1.0002, 1.02; <i>I</i><sup>2</sup> = 79%) for PD.</p><p><strong>Conclusion: </strong>Ambient air pollution, particularly PM<sub>2.5</sub>, may contribute to the increased risks of neurodegenerative diseases including AD and PD.</p>\",\"PeriodicalId\":23195,\"journal\":{\"name\":\"Toxics\",\"volume\":\"13 2\",\"pages\":\"\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-02-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxics\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.3390/toxics13020139\",\"RegionNum\":3,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxics","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.3390/toxics13020139","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Ambient Air Pollution and Parkinson's Disease and Alzheimer's Disease: An Updated Meta-Analysis.
Background: Previous epidemiological evidence regarding the associations between ambient air pollution and two major neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD), remains inconclusive.
Objective: This study aimed to evaluate the associations between long-term and short-term exposure to PM2.5 and PM10 (i.e., particulate matter with an aerodynamic diameter of, or smaller than, 2.5 μm or 10 μm), nitrogen dioxide (NO2), ozone, sulfur dioxide, and carbon monoxide and the risks of AD and PD.
Methods: A random-effects model was used to summarize individual effect estimates in the meta-analysis. A subgroup meta-analysis was further conducted to explore the potential sources of heterogeneity.
Results: In total, 42 eligible studies were included. For each 5 μg/m3 increase in long-term PM2.5 exposure, the odds ratios (ORs) were 1.16 (95% CI: 1.04, 1.30; I2 = 95%) and 1.10 (95% CI: 1.03, 1.17; I2 = 95%) for AD and PD, respectively. For each 5 μg/m3 increase in short-term PM2.5 exposure, the OR was 1.01 (95% CI: 1.002, 1.01; I2 = 77%) for PD. For each 1 ppb increase in long-term NO2 exposure, the OR was 1.01 (95% CI: 1.0002, 1.02; I2 = 79%) for PD.
Conclusion: Ambient air pollution, particularly PM2.5, may contribute to the increased risks of neurodegenerative diseases including AD and PD.
ToxicsChemical Engineering-Chemical Health and Safety
CiteScore
4.50
自引率
10.90%
发文量
681
审稿时长
6 weeks
期刊介绍：
Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.
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